Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30727 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ. Brasil. |
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Guimarães, Erick VazCarvalho, Laís deBarbosa, Helene Santos2018-12-20T15:45:48Z2018-12-20T15:45:48Z2009GUIMARÃES, Erick Vaz; CARVALHO, Laís de; BARBOSA, Helene Santos. Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro. Mem Inst Oswaldo Cruz, v.104, n.2, p.170-174, Mar. 2009.0074-0276https://www.arca.fiocruz.br/handle/icict/307271678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzToxoplasma gondiicélulas musculares esqueléticascistogênesecistos teciduaisToxoplasma gondiitissue cystsbradyzoitescystogenesisskeletal muscle cellsInteraction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Histologia e Embriologia. Laboratório de Cultura de Células. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ. Brasil.Infection by the protozoan parasite Toxoplasma gondii is widely prevalent in humans and animals. To prevent human infection, all meat should be well cooked before consumption, since the parasite is present in skeletal muscle. In this context, the use of skeletal muscle cells (SkMCs) as a cellular model opens up new approaches to investigate T. gondii-host cell interactions. Immunofluorescent detection of proteins that are stage-specific for bradyzoites indicated that complete cystogenesis of T. gondii in in vitro cultures of SkMCs occurs after 96 h of infection. Ultrastructural analysis showed that, after 48 h of interaction, there were alterations on the parasitophorous vacuole membrane, including greater thickness and increased electron density at the inner face of the membrane. The present study demonstrates the potential use of primary cultures of SkMCs to evaluate different molecular aspects of T. gondii invasion and cystogenesis and presents a promising in vitro model for the screening of drug activities toward tissue cysts and bradyzoites.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30727/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALericguimaraes_helenebarbosa_etal_IOC_2009.pdfericguimaraes_helenebarbosa_etal_IOC_2009.pdfapplication/pdf801757https://www.arca.fiocruz.br/bitstream/icict/30727/2/ericguimaraes_helenebarbosa_etal_IOC_2009.pdffee6625f7ee25d83de0532c8f2c0c87eMD52TEXTericguimaraes_helenebarbosa_etal_IOC_2009.pdf.txtericguimaraes_helenebarbosa_etal_IOC_2009.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro |
title |
Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro |
spellingShingle |
Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro Guimarães, Erick Vaz Toxoplasma gondii células musculares esqueléticas cistogênese cistos teciduais Toxoplasma gondii tissue cysts bradyzoites cystogenesis skeletal muscle cells |
title_short |
Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro |
title_full |
Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro |
title_fullStr |
Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro |
title_full_unstemmed |
Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro |
title_sort |
Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro |
author |
Guimarães, Erick Vaz |
author_facet |
Guimarães, Erick Vaz Carvalho, Laís de Barbosa, Helene Santos |
author_role |
author |
author2 |
Carvalho, Laís de Barbosa, Helene Santos |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Guimarães, Erick Vaz Carvalho, Laís de Barbosa, Helene Santos |
dc.subject.other.pt_BR.fl_str_mv |
Toxoplasma gondii células musculares esqueléticas cistogênese cistos teciduais |
topic |
Toxoplasma gondii células musculares esqueléticas cistogênese cistos teciduais Toxoplasma gondii tissue cysts bradyzoites cystogenesis skeletal muscle cells |
dc.subject.en.pt_BR.fl_str_mv |
Toxoplasma gondii tissue cysts bradyzoites cystogenesis skeletal muscle cells |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ. Brasil. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2018-12-20T15:45:48Z |
dc.date.available.fl_str_mv |
2018-12-20T15:45:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GUIMARÃES, Erick Vaz; CARVALHO, Laís de; BARBOSA, Helene Santos. Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro. Mem Inst Oswaldo Cruz, v.104, n.2, p.170-174, Mar. 2009. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/30727 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
GUIMARÃES, Erick Vaz; CARVALHO, Laís de; BARBOSA, Helene Santos. Interaction and cystogenesis of Toxoplasma gondii within skeletal muscle cells in vitro. Mem Inst Oswaldo Cruz, v.104, n.2, p.170-174, Mar. 2009. 0074-0276 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/30727 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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