Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.

Rocha, Nazareth de Novaes; Macambira, Simone Garcia; Giménez, L. E. D; Hernandez, C. C. Q; Senra, Juliana Fraga Vasconcelos; Lima, Ricardo Santana de; Cyrino, F; Bouskela, Eliete; Soares, Milena Botelho Pereira; Santos, Ricardo Ribeiro dos

Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.

Detalhes bibliográficos
Autor(a) principal:	Rocha, Nazareth de Novaes
Data de Publicação:	2006
Outros Autores:	Macambira, Simone Garcia, Giménez, L. E. D, Hernandez, C. C. Q, Senra, Juliana Fraga Vasconcelos, Lima, Ricardo Santana de, Cyrino, F, Bouskela, Eliete, Soares, Milena Botelho Pereira, Santos, Ricardo Ribeiro dos
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/10015
Resumo:	Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Niterói, RJ, Brasil

Metadados do item

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spelling	Rocha, Nazareth de NovaesMacambira, Simone GarciaGiménez, L. E. DHernandez, C. C. QSenra, Juliana Fraga VasconcelosLima, Ricardo Santana deCyrino, FBouskela, ElieteSoares, Milena Botelho PereiraSantos, Ricardo Ribeiro dos2015-04-15T19:12:10Z2015-04-15T19:12:10Z2006ROCHA, N. N. et al. Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection. Parasitology, v. 133, n. Pt 6, p. 729-737, 2006.0031-1820https://www.arca.fiocruz.br/handle/icict/10015engCambridge University PressCharacterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Niterói, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, BrasilUniversidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil: Circulating antibodies in chagasic patients interact with myocardial beta adrenergic and muscarinic cholinergic receptors, triggering intracellular signals that alter cardiac function along the course of the disease. However, until now, experimental data in models of chronically infected chagasic mice linking the effects on myocardial beta adrenergic and muscarinic receptors to cardiopulmonary dysfunction is lacking. Thus, we studied C57BL/6 mice 8 months after intraperitoneal injection of 100 trypomastigote forms of the Colombian strain of T. cruzi. Uninfected mice, matched in age, were used as controls. Histopathological analyses (inflammation and fibrosis) and radio-ligand binding assays for estimation of muscarinic and adrenergic receptor density were performed in myocardium tissue samples. When compared to controls, infected mice had electrical conduction disturbances, diastolic dysfunction, lower O2 consumption and anaerobic threshold. In addition, hearts of chronic chagasic mice had intense inflammation and fibrosis, and decreased beta adrenergic and increased muscarinic receptor densities than normal controls. Our data suggest that chronic T. cruzi infection causes alterations in cardiac receptor density and fibrosis deposition which can be associated with cardiac conduction abnormalities, diastolic dysfunction and lower exercise capacity, associating for the first time all these functional and histopathological alterations in chagasic miceChagas’ diseaseCardiopulmonary functionCardiac receptorsMouse modelCardiomiopatia Chagásica/fisiopatologiaMiocárdio/metabolismoReceptor Muscarínico M2/metabolismoReceptores Adrenérgicos beta 1/metabolismoAnimaisCardiomiopatia Chagásica/parasitologiaDoença CrônicaModelos Animais de DoençasRegulação para BaixoEcocardiografiaEletrocardiografiaFemininoTeste de EsforçoCoração/parasitologiaHumanosCamundongosCamundongos Endogâmicos C57BLMiocárdio/patologiaTrypanosoma cruzi/patogenicidadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALRocha N N Characterization of....pdfRocha N N Characterization of....pdfapplication/pdf130180https://www.arca.fiocruz.br/bitstream/icict/10015/2/Rocha%20N%20N%20Characterization%20of....pdfd9995f076aa0e69d1ae1a91d9cadccc7MD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv	Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.
title	Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.
spellingShingle	Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection. Rocha, Nazareth de Novaes Chagas’ disease Cardiopulmonary function Cardiac receptors Mouse model Cardiomiopatia Chagásica/fisiopatologia Miocárdio/metabolismo Receptor Muscarínico M2/metabolismo Receptores Adrenérgicos beta 1/metabolismo Animais Cardiomiopatia Chagásica/parasitologia Doença Crônica Modelos Animais de Doenças Regulação para Baixo Ecocardiografia Eletrocardiografia Feminino Teste de Esforço Coração/parasitologia Humanos Camundongos Camundongos Endogâmicos C57BL Miocárdio/patologia Trypanosoma cruzi/patogenicidade
title_short	Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.
title_full	Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.
title_fullStr	Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.
title_full_unstemmed	Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.
title_sort	Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.
author	Rocha, Nazareth de Novaes
author_facet	Rocha, Nazareth de Novaes Macambira, Simone Garcia Giménez, L. E. D Hernandez, C. C. Q Senra, Juliana Fraga Vasconcelos Lima, Ricardo Santana de Cyrino, F Bouskela, Eliete Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos
author_role	author
author2	Macambira, Simone Garcia Giménez, L. E. D Hernandez, C. C. Q Senra, Juliana Fraga Vasconcelos Lima, Ricardo Santana de Cyrino, F Bouskela, Eliete Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos
author2_role	author author author author author author author author author
dc.contributor.author.fl_str_mv	Rocha, Nazareth de Novaes Macambira, Simone Garcia Giménez, L. E. D Hernandez, C. C. Q Senra, Juliana Fraga Vasconcelos Lima, Ricardo Santana de Cyrino, F Bouskela, Eliete Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos
dc.subject.en.pt_BR.fl_str_mv	Chagas’ disease Cardiopulmonary function Cardiac receptors Mouse model
topic	Chagas’ disease Cardiopulmonary function Cardiac receptors Mouse model Cardiomiopatia Chagásica/fisiopatologia Miocárdio/metabolismo Receptor Muscarínico M2/metabolismo Receptores Adrenérgicos beta 1/metabolismo Animais Cardiomiopatia Chagásica/parasitologia Doença Crônica Modelos Animais de Doenças Regulação para Baixo Ecocardiografia Eletrocardiografia Feminino Teste de Esforço Coração/parasitologia Humanos Camundongos Camundongos Endogâmicos C57BL Miocárdio/patologia Trypanosoma cruzi/patogenicidade
dc.subject.decs.pt_BR.fl_str_mv	Cardiomiopatia Chagásica/fisiopatologia Miocárdio/metabolismo Receptor Muscarínico M2/metabolismo Receptores Adrenérgicos beta 1/metabolismo Animais Cardiomiopatia Chagásica/parasitologia Doença Crônica Modelos Animais de Doenças Regulação para Baixo Ecocardiografia Eletrocardiografia Feminino Teste de Esforço Coração/parasitologia Humanos Camundongos Camundongos Endogâmicos C57BL Miocárdio/patologia Trypanosoma cruzi/patogenicidade
description	Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Niterói, RJ, Brasil
publishDate	2006
dc.date.issued.fl_str_mv	2006
dc.date.accessioned.fl_str_mv	2015-04-15T19:12:10Z
dc.date.available.fl_str_mv	2015-04-15T19:12:10Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ROCHA, N. N. et al. Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection. Parasitology, v. 133, n. Pt 6, p. 729-737, 2006.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/10015
dc.identifier.issn.none.fl_str_mv	0031-1820
identifier_str_mv	ROCHA, N. N. et al. Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection. Parasitology, v. 133, n. Pt 6, p. 729-737, 2006. 0031-1820
url	https://www.arca.fiocruz.br/handle/icict/10015
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Cambridge University Press
publisher.none.fl_str_mv	Cambridge University Press
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.

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