Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28897 |
Resumo: | O artigo encontra-se disponível em acesso aberto no site do Editor. |
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Silveira, Guilherme FerreiraMeyer, FlorenciaDelfraro, AdrianaMosimann, Ana Luiza PamplonaColuchi, NormaVasquez, CyntiaProbst, Christian MacagnanBáfica, AndréBordignon, JulianoSantos, Claudia Nunes Duarte dos2018-09-19T16:45:53Z2018-09-19T16:45:53Z2011SILVEIRA, Guilherme F. et al. Dengue Virus Type 3 Isolated from a Fatal Case with Visceral Complications Induces Enhanced Proinflammatory Responses and Apoptosis of Human Dendritic Cells. Journal of Virology, v. 85, n. 11, p. 5374–5383, 2011.0022-538Xhttps://www.arca.fiocruz.br/handle/icict/2889710.1128/JVI.01915-101098-5514O artigo encontra-se disponível em acesso aberto no site do Editor.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, BrasilFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, BrasilFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil / Universidade de la Republica. Facultad de Ciencias. Sección Virologia, Montevideo, Uruguai.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Instituto de Previsión Social. Laboratorio Central de Salud Publica. Servicio de Pediatria, Asuncion, Paraguay.Instituto de Previsión Social. Laboratorio Central de Salud Publica. Servicio de Pediatria, Asuncion, Paraguay.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil.Universidade Federal de Santa Catarina. Laboratório de Imunofarmacologia e Doenças Infecciosas. Florianópolis, SC, BrazilFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.A recent (2007 to 2009) dengue outbreak caused by dengue virus (DENV) in Paraguay presented unusual severe clinical outcomes associated with 50% mortality rates. Although it has been reported that inflammatory responses influence the severity of dengue virus infection (T. Pang, M. J. Cardosa, and M. G. Guzman, Immunol. Cell Biol. 85:43-45, 2007), there remains a paucity of information on virus-innate immunity interactions influencing clinical outcome. Using human dendritic cells from a major innate immune cell population as an in vitro model, we have investigated signature cytokine responses as well as infectivity-replicative profiles of DENV clinical isolates from either a nonfatal case of classical dengue fever (strain DENV3/290; isolated in Brazil in 2002) or a fatal case of dengue fever with visceral complications isolated in Paraguay in 2007 (strain DENV3/5532). Strain DENV3/5532 was found to display significantly higher replicative ability than DENV3/290 in monocyte-derived dendritic cells (mdDCs). In addition, compared to DENV3/290 results, mdDCs exposed to DENV3/5532 showed increased production of proinflammatory cytokines associated with higher rates of programmed cell death, as shown by annexin V staining. The observed phenotype was due to viral replication, and tumor necrosis factor alpha (TNF-α) appears to exert a protective effect on virus-induced mdDC apoptosis. These results suggest that the DENV3/5532 strain isolated from the fatal case replicates within human dendritic cells, modulating cell survival and synthesis of inflammatory mediators.porAmerican Society for MicrobiologyDengueDendritic CellsCytokinesDengue VirusPyroptosisCélulas DendríticasCitocinasVirus del DenguePiroptosisCélulas DendríticasCitocinasVírus da DenguePiroptoseDengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells |
| title |
Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells |
| spellingShingle |
Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells Silveira, Guilherme Ferreira Dengue Dendritic Cells Cytokines Dengue Virus Pyroptosis Células Dendríticas Citocinas Virus del Dengue Piroptosis Células Dendríticas Citocinas Vírus da Dengue Piroptose |
| title_short |
Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells |
| title_full |
Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells |
| title_fullStr |
Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells |
| title_full_unstemmed |
Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells |
| title_sort |
Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells |
| author |
Silveira, Guilherme Ferreira |
| author_facet |
Silveira, Guilherme Ferreira Meyer, Florencia Delfraro, Adriana Mosimann, Ana Luiza Pamplona Coluchi, Norma Vasquez, Cyntia Probst, Christian Macagnan Báfica, André Bordignon, Juliano Santos, Claudia Nunes Duarte dos |
| author_role |
author |
| author2 |
Meyer, Florencia Delfraro, Adriana Mosimann, Ana Luiza Pamplona Coluchi, Norma Vasquez, Cyntia Probst, Christian Macagnan Báfica, André Bordignon, Juliano Santos, Claudia Nunes Duarte dos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silveira, Guilherme Ferreira Meyer, Florencia Delfraro, Adriana Mosimann, Ana Luiza Pamplona Coluchi, Norma Vasquez, Cyntia Probst, Christian Macagnan Báfica, André Bordignon, Juliano Santos, Claudia Nunes Duarte dos |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue |
| topic |
Dengue Dendritic Cells Cytokines Dengue Virus Pyroptosis Células Dendríticas Citocinas Virus del Dengue Piroptosis Células Dendríticas Citocinas Vírus da Dengue Piroptose |
| dc.subject.en.pt_BR.fl_str_mv |
Dendritic Cells Cytokines Dengue Virus Pyroptosis |
| dc.subject.es.pt_BR.fl_str_mv |
Células Dendríticas Citocinas Virus del Dengue Piroptosis |
| dc.subject.decs.pt_BR.fl_str_mv |
Células Dendríticas Citocinas Vírus da Dengue Piroptose |
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O artigo encontra-se disponível em acesso aberto no site do Editor. |
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2011 |
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2011 |
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2018-09-19T16:45:53Z |
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2018-09-19T16:45:53Z |
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info:eu-repo/semantics/article |
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SILVEIRA, Guilherme F. et al. Dengue Virus Type 3 Isolated from a Fatal Case with Visceral Complications Induces Enhanced Proinflammatory Responses and Apoptosis of Human Dendritic Cells. Journal of Virology, v. 85, n. 11, p. 5374–5383, 2011. |
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https://www.arca.fiocruz.br/handle/icict/28897 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0022-538X |
| dc.identifier.doi.none.fl_str_mv |
10.1128/JVI.01915-10 |
| dc.identifier.eissn.none.fl_str_mv |
1098-5514 |
| identifier_str_mv |
SILVEIRA, Guilherme F. et al. Dengue Virus Type 3 Isolated from a Fatal Case with Visceral Complications Induces Enhanced Proinflammatory Responses and Apoptosis of Human Dendritic Cells. Journal of Virology, v. 85, n. 11, p. 5374–5383, 2011. 0022-538X 10.1128/JVI.01915-10 1098-5514 |
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American Society for Microbiology |
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American Society for Microbiology |
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