Dendritic cell apoptosis and the pathogenesis of dengue

Detalhes bibliográficos
Autor(a) principal: Martins, Sharon de Toledo
Data de Publicação: 2012
Outros Autores: Silveira, Guilherme Ferreira, Alves, Lysangela Ronalte, Santos, Claudia Nunes Duarte dos, Bordignon, Juliano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37921
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil.
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spelling Martins, Sharon de ToledoSilveira, Guilherme FerreiraAlves, Lysangela RonalteSantos, Claudia Nunes Duarte dosBordignon, Juliano2019-12-12T19:25:22Z2019-12-12T19:25:22Z2012MARTINS, Sharon de Toledo et al. Dendritic cell apoptosis and the pathogenesis of dengue. Viruses, São Paulo, n. 4, p. 2736-2753, 2012.1999-4915https://www.arca.fiocruz.br/handle/icict/3792110.3390/v4112736MDPIDendritic cell apoptosis and the pathogenesis of dengueinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Dengue viruses and other members of the Flaviviridae family are emerging human pathogens. Dengue is transmitted to humans by Aedes aegypti female mosquitoes. Following infection through the bite, cells of the hematopoietic lineage, like dendritic cells, are the first targets of dengue virus infection. Dendritic cells (DCs) are key antigen presenting cells, sensing pathogens, processing and presenting the antigens to T lymphocytes, and triggering an adaptive immune response. Infection of DCs by dengue virus may induce apoptosis, impairing their ability to present antigens to T cells, and thereby contributing to dengue pathogenesis. This review focuses on general mechanisms by which dengue virus triggers apoptosis, and possible influence of DC-apoptosis on dengue disease severity.Dendritic CellsApoptosisDengue VirusVirus del DengueCélulas DendríticasApoptoseVírus da Dengueinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/37921/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALviruses-04-0273ok.pdfviruses-04-0273ok.pdfapplication/pdf889494https://www.arca.fiocruz.br/bitstream/icict/37921/2/viruses-04-0273ok.pdfa553fe28520595c8a94bf81aa497d5c9MD52TEXTviruses-04-0273ok.pdf.txtviruses-04-0273ok.pdf.txtExtracted texttext/plain55669https://www.arca.fiocruz.br/bitstream/icict/37921/3/viruses-04-0273ok.pdf.txt50c8c41c75aefe4d10ba5d23c7cbdbaeMD53icict/379212019-12-13 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dc.title.pt_BR.fl_str_mv Dendritic cell apoptosis and the pathogenesis of dengue
title Dendritic cell apoptosis and the pathogenesis of dengue
spellingShingle Dendritic cell apoptosis and the pathogenesis of dengue
Martins, Sharon de Toledo
Dendritic Cells
Apoptosis
Dengue Virus
Virus del Dengue
Células Dendríticas
Apoptose
Vírus da Dengue
title_short Dendritic cell apoptosis and the pathogenesis of dengue
title_full Dendritic cell apoptosis and the pathogenesis of dengue
title_fullStr Dendritic cell apoptosis and the pathogenesis of dengue
title_full_unstemmed Dendritic cell apoptosis and the pathogenesis of dengue
title_sort Dendritic cell apoptosis and the pathogenesis of dengue
author Martins, Sharon de Toledo
author_facet Martins, Sharon de Toledo
Silveira, Guilherme Ferreira
Alves, Lysangela Ronalte
Santos, Claudia Nunes Duarte dos
Bordignon, Juliano
author_role author
author2 Silveira, Guilherme Ferreira
Alves, Lysangela Ronalte
Santos, Claudia Nunes Duarte dos
Bordignon, Juliano
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Martins, Sharon de Toledo
Silveira, Guilherme Ferreira
Alves, Lysangela Ronalte
Santos, Claudia Nunes Duarte dos
Bordignon, Juliano
dc.subject.en.pt_BR.fl_str_mv Dendritic Cells
Apoptosis
Dengue Virus
topic Dendritic Cells
Apoptosis
Dengue Virus
Virus del Dengue
Células Dendríticas
Apoptose
Vírus da Dengue
dc.subject.es.pt_BR.fl_str_mv Virus del Dengue
dc.subject.decs.pt_BR.fl_str_mv Células Dendríticas
Apoptose
Vírus da Dengue
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-12-12T19:25:22Z
dc.date.available.fl_str_mv 2019-12-12T19:25:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINS, Sharon de Toledo et al. Dendritic cell apoptosis and the pathogenesis of dengue. Viruses, São Paulo, n. 4, p. 2736-2753, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37921
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v4112736
identifier_str_mv MARTINS, Sharon de Toledo et al. Dendritic cell apoptosis and the pathogenesis of dengue. Viruses, São Paulo, n. 4, p. 2736-2753, 2012.
1999-4915
10.3390/v4112736
url https://www.arca.fiocruz.br/handle/icict/37921
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/37921/2/viruses-04-0273ok.pdf
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