Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes

Detalhes bibliográficos
Autor(a) principal: Assis, Edson F. de
Data de Publicação: 2003
Outros Autores: Silva, Adriana R., Caiado, Lara F. C., Marathe, Gopal K., Zimmerman, Guy A., Prescott, Stephen M., McIntyre, Thomas M., Bozza, Patrícia T., Faria Neto, Hugo Caire C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40904
Resumo: Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/171/4/2090.full.pdf
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spelling Assis, Edson F. deSilva, Adriana R.Caiado, Lara F. C.Marathe, Gopal K.Zimmerman, Guy A.Prescott, Stephen M.McIntyre, Thomas M.Bozza, Patrícia T.Faria Neto, Hugo Caire C.2020-04-21T15:12:30Z2020-04-21T15:12:30Z2003ASSIS, Edson F. de et al. Synergism Between Platelet-Activating Factor-Like Phospholipids and Peroxisome Proliferator-Activated Receptor Agonists Generated During Low Density Lipoprotein Oxidation That Induces Lipid Body Formation in Leukocytes. Journal of Immunology, v. 171, p. 2090-2098, 2003.0022-1767https://www.arca.fiocruz.br/handle/icict/4090410.4049/jimmunol.171.4.20901550-6606Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/171/4/2090.full.pdfFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.University of Utah. Department of Pathology. Salt Lake City, UT, USA.University of Utah. Department of Internal Medicine. Salt Lake City, UT, USA / University of Utah. Program in Human Molecular Biology and Genetics.Salt Lake City, UT, USA.University of Utah. Department of Internal Medicine. Salt Lake City, UT, USA / University of Utah. Huntsman Cancer Institute. Salt Lake City, UT. USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / University of Utah. Department of Pathology. Salt Lake City, UT, USA / University of Utah. Program in Human Molecular Biology and Genetics.Salt Lake City, UT, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Oxidized low density lipoprotein (LDL) has an important proinflammatory role in atherogenesis. In this study, we investigated the ability of oxidized LDL (oxLDL) and its phospholipid components to induce lipid body formation in leukocytes. Incubation of mouse peritoneal macrophages with oxidized, but not with native LDL led to lipid body formation within 1 h. This was blocked by platelet-activating factor (PAF) receptor antagonists or by preincubation of oxLDL with rPAF acetylhydrolase. HPLC fractions of phospholipids purified from oxLDL induced calcium flux in neutrophils as well as lipid body formation in macrophages. Injection of the bioactive phospholipid fractions or butanoyl and butenoyl PAF, a phospholipid previously shown to be present in oxLDL, into the pleural cavity of mice induced lipid body formation in leukocytes recovered after 3 h. The 5-lipoxygenase and cyclooxygenase-2 colocalized within lipid bodies formed after stimulation with oxLDL, bioactive phospholipid fractions, or butanoyl and butenoyl PAF. Lipid body formation was inhibited by 5-lipoxygenase antagonists, but not by cyclooxygenase-2 inhibitors. Azelaoyl-phosphatidylcholine, a peroxisome proliferator-activated receptor-gamma agonist in oxLDL phospholipid fractions, induced formation of lipid bodies at late time points (6 h) and synergized with suboptimal concentrations of oxLDL. We conclude that lipid body formation is an important proinflammatory effect of oxLDL and that PAF-like phospholipids and peroxisome proliferator-activated receptor-gamma agonists generated during LDL oxidation are important mediators in this phenomenon.engAmerican Association of ImmunologistsSinergismoFator Ativador de PlaquetasLipoproteína de Baixa DensidadeLipídiosLeucócitosPlatelet-Activating Factor-LikeSynergismLow Density LipoproteinLipid Body Formation in LeukocytesSynergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
title Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
spellingShingle Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
Assis, Edson F. de
Sinergismo
Fator Ativador de Plaquetas
Lipoproteína de Baixa Densidade
Lipídios
Leucócitos
Platelet-Activating Factor-Like
Synergism
Low Density Lipoprotein
Lipid Body Formation in Leukocytes
title_short Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
title_full Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
title_fullStr Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
title_full_unstemmed Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
title_sort Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
author Assis, Edson F. de
author_facet Assis, Edson F. de
Silva, Adriana R.
Caiado, Lara F. C.
Marathe, Gopal K.
Zimmerman, Guy A.
Prescott, Stephen M.
McIntyre, Thomas M.
Bozza, Patrícia T.
Faria Neto, Hugo Caire C.
author_role author
author2 Silva, Adriana R.
Caiado, Lara F. C.
Marathe, Gopal K.
Zimmerman, Guy A.
Prescott, Stephen M.
McIntyre, Thomas M.
Bozza, Patrícia T.
Faria Neto, Hugo Caire C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Assis, Edson F. de
Silva, Adriana R.
Caiado, Lara F. C.
Marathe, Gopal K.
Zimmerman, Guy A.
Prescott, Stephen M.
McIntyre, Thomas M.
Bozza, Patrícia T.
Faria Neto, Hugo Caire C.
dc.subject.other.pt_BR.fl_str_mv Sinergismo
Fator Ativador de Plaquetas
Lipoproteína de Baixa Densidade
Lipídios
Leucócitos
topic Sinergismo
Fator Ativador de Plaquetas
Lipoproteína de Baixa Densidade
Lipídios
Leucócitos
Platelet-Activating Factor-Like
Synergism
Low Density Lipoprotein
Lipid Body Formation in Leukocytes
dc.subject.en.pt_BR.fl_str_mv Platelet-Activating Factor-Like
Synergism
Low Density Lipoprotein
Lipid Body Formation in Leukocytes
description Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/171/4/2090.full.pdf
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2020-04-21T15:12:30Z
dc.date.available.fl_str_mv 2020-04-21T15:12:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ASSIS, Edson F. de et al. Synergism Between Platelet-Activating Factor-Like Phospholipids and Peroxisome Proliferator-Activated Receptor Agonists Generated During Low Density Lipoprotein Oxidation That Induces Lipid Body Formation in Leukocytes. Journal of Immunology, v. 171, p. 2090-2098, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40904
dc.identifier.issn.pt_BR.fl_str_mv 0022-1767
dc.identifier.doi.none.fl_str_mv 10.4049/jimmunol.171.4.2090
dc.identifier.eissn.none.fl_str_mv 1550-6606
identifier_str_mv ASSIS, Edson F. de et al. Synergism Between Platelet-Activating Factor-Like Phospholipids and Peroxisome Proliferator-Activated Receptor Agonists Generated During Low Density Lipoprotein Oxidation That Induces Lipid Body Formation in Leukocytes. Journal of Immunology, v. 171, p. 2090-2098, 2003.
0022-1767
10.4049/jimmunol.171.4.2090
1550-6606
url https://www.arca.fiocruz.br/handle/icict/40904
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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