Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40904 |
Resumo: | Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/171/4/2090.full.pdf |
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Assis, Edson F. deSilva, Adriana R.Caiado, Lara F. C.Marathe, Gopal K.Zimmerman, Guy A.Prescott, Stephen M.McIntyre, Thomas M.Bozza, Patrícia T.Faria Neto, Hugo Caire C.2020-04-21T15:12:30Z2020-04-21T15:12:30Z2003ASSIS, Edson F. de et al. Synergism Between Platelet-Activating Factor-Like Phospholipids and Peroxisome Proliferator-Activated Receptor Agonists Generated During Low Density Lipoprotein Oxidation That Induces Lipid Body Formation in Leukocytes. Journal of Immunology, v. 171, p. 2090-2098, 2003.0022-1767https://www.arca.fiocruz.br/handle/icict/4090410.4049/jimmunol.171.4.20901550-6606Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/171/4/2090.full.pdfFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.University of Utah. Department of Pathology. Salt Lake City, UT, USA.University of Utah. Department of Internal Medicine. Salt Lake City, UT, USA / University of Utah. Program in Human Molecular Biology and Genetics.Salt Lake City, UT, USA.University of Utah. Department of Internal Medicine. Salt Lake City, UT, USA / University of Utah. Huntsman Cancer Institute. Salt Lake City, UT. USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / University of Utah. Department of Pathology. Salt Lake City, UT, USA / University of Utah. Program in Human Molecular Biology and Genetics.Salt Lake City, UT, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Oxidized low density lipoprotein (LDL) has an important proinflammatory role in atherogenesis. In this study, we investigated the ability of oxidized LDL (oxLDL) and its phospholipid components to induce lipid body formation in leukocytes. Incubation of mouse peritoneal macrophages with oxidized, but not with native LDL led to lipid body formation within 1 h. This was blocked by platelet-activating factor (PAF) receptor antagonists or by preincubation of oxLDL with rPAF acetylhydrolase. HPLC fractions of phospholipids purified from oxLDL induced calcium flux in neutrophils as well as lipid body formation in macrophages. Injection of the bioactive phospholipid fractions or butanoyl and butenoyl PAF, a phospholipid previously shown to be present in oxLDL, into the pleural cavity of mice induced lipid body formation in leukocytes recovered after 3 h. The 5-lipoxygenase and cyclooxygenase-2 colocalized within lipid bodies formed after stimulation with oxLDL, bioactive phospholipid fractions, or butanoyl and butenoyl PAF. Lipid body formation was inhibited by 5-lipoxygenase antagonists, but not by cyclooxygenase-2 inhibitors. Azelaoyl-phosphatidylcholine, a peroxisome proliferator-activated receptor-gamma agonist in oxLDL phospholipid fractions, induced formation of lipid bodies at late time points (6 h) and synergized with suboptimal concentrations of oxLDL. We conclude that lipid body formation is an important proinflammatory effect of oxLDL and that PAF-like phospholipids and peroxisome proliferator-activated receptor-gamma agonists generated during LDL oxidation are important mediators in this phenomenon.engAmerican Association of ImmunologistsSinergismoFator Ativador de PlaquetasLipoproteína de Baixa DensidadeLipídiosLeucócitosPlatelet-Activating Factor-LikeSynergismLow Density LipoproteinLipid Body Formation in LeukocytesSynergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes |
title |
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes |
spellingShingle |
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes Assis, Edson F. de Sinergismo Fator Ativador de Plaquetas Lipoproteína de Baixa Densidade Lipídios Leucócitos Platelet-Activating Factor-Like Synergism Low Density Lipoprotein Lipid Body Formation in Leukocytes |
title_short |
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes |
title_full |
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes |
title_fullStr |
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes |
title_full_unstemmed |
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes |
title_sort |
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes |
author |
Assis, Edson F. de |
author_facet |
Assis, Edson F. de Silva, Adriana R. Caiado, Lara F. C. Marathe, Gopal K. Zimmerman, Guy A. Prescott, Stephen M. McIntyre, Thomas M. Bozza, Patrícia T. Faria Neto, Hugo Caire C. |
author_role |
author |
author2 |
Silva, Adriana R. Caiado, Lara F. C. Marathe, Gopal K. Zimmerman, Guy A. Prescott, Stephen M. McIntyre, Thomas M. Bozza, Patrícia T. Faria Neto, Hugo Caire C. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Assis, Edson F. de Silva, Adriana R. Caiado, Lara F. C. Marathe, Gopal K. Zimmerman, Guy A. Prescott, Stephen M. McIntyre, Thomas M. Bozza, Patrícia T. Faria Neto, Hugo Caire C. |
dc.subject.other.pt_BR.fl_str_mv |
Sinergismo Fator Ativador de Plaquetas Lipoproteína de Baixa Densidade Lipídios Leucócitos |
topic |
Sinergismo Fator Ativador de Plaquetas Lipoproteína de Baixa Densidade Lipídios Leucócitos Platelet-Activating Factor-Like Synergism Low Density Lipoprotein Lipid Body Formation in Leukocytes |
dc.subject.en.pt_BR.fl_str_mv |
Platelet-Activating Factor-Like Synergism Low Density Lipoprotein Lipid Body Formation in Leukocytes |
description |
Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/171/4/2090.full.pdf |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003 |
dc.date.accessioned.fl_str_mv |
2020-04-21T15:12:30Z |
dc.date.available.fl_str_mv |
2020-04-21T15:12:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ASSIS, Edson F. de et al. Synergism Between Platelet-Activating Factor-Like Phospholipids and Peroxisome Proliferator-Activated Receptor Agonists Generated During Low Density Lipoprotein Oxidation That Induces Lipid Body Formation in Leukocytes. Journal of Immunology, v. 171, p. 2090-2098, 2003. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/40904 |
dc.identifier.issn.pt_BR.fl_str_mv |
0022-1767 |
dc.identifier.doi.none.fl_str_mv |
10.4049/jimmunol.171.4.2090 |
dc.identifier.eissn.none.fl_str_mv |
1550-6606 |
identifier_str_mv |
ASSIS, Edson F. de et al. Synergism Between Platelet-Activating Factor-Like Phospholipids and Peroxisome Proliferator-Activated Receptor Agonists Generated During Low Density Lipoprotein Oxidation That Induces Lipid Body Formation in Leukocytes. Journal of Immunology, v. 171, p. 2090-2098, 2003. 0022-1767 10.4049/jimmunol.171.4.2090 1550-6606 |
url |
https://www.arca.fiocruz.br/handle/icict/40904 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
American Association of Immunologists |
publisher.none.fl_str_mv |
American Association of Immunologists |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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