Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli

Detalhes bibliográficos
Autor(a) principal: Alcântara, Lorena Kimberly Silva
Data de Publicação: 2021
Outros Autores: Machado, Luiz Felipe Carreiro, Ceravolo, Isabela Penna, Santos, Renan Martins dos, Souza, Marcus Vinícius Dias
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51131
Resumo: PharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil
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spelling Alcântara, Lorena Kimberly SilvaMachado, Luiz Felipe CarreiroCeravolo, Isabela PennaSantos, Renan Martins dosSouza, Marcus Vinícius Dias2022-02-10T13:09:57Z2022-02-10T13:09:57Z2021ALCÂNTARA, Lorena Kimberly Silva et al. Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli. Biointerface Research in Applied Chemistry, v. 11, n. 1, p. 8210 – 8217, 2021. doi.org/10.33263/BRIAC111.821082172069-5837https://www.arca.fiocruz.br/handle/icict/51131engResurchifyPhytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coliinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, BrazilPharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, BrazilRené Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, BrazilPharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil/Integrated Pharmacology and Drug Interactions Research Group. BrazilPharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil/Integrated Pharmacology and Drug Interactions Research Group. BrazilEscherichia coli is naturally present at the gastrointestinal tract of humans, but is also involved in diseases such as urinary tract infection. The current scenario of bacterial resistance to antimicrobials raises the demand for new drugs, and natural products represent interesting sources of bioactive compounds. Here we investigated the cytotoxicity and antimicrobial potential of 80% methanolic extracts of Spondias tuberosa (umbu), Spondias purpurea (seriguela), and Theobroma grandiflorum (cupuaçu) fruit juice pulps against clinical isolates of uropathogenic E. coli. Phytochemical aspects of the pulps were elucidated, and their antioxidant properties were analyzed. The minimal inhibitory concentration (MIC) of the extracts was of 500 µg/mL, and no toxicity was observed against BGM cells. Vitamin C and total carbohydrates were not in accordance to the levels determined in the legislation. We used HPLC to confirm the presence of flavonoids. To the best of our knowledge, this is the first report of the antimicrobial potential of these fruit pulps. Our data open doors for more studies with chromatographic fractions and isolated flavonoids from these pulps.plant extracturopathogenic E. coliantimicrobialumbuseriguelacupuaçuinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51131/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALPhytochemical Aspects, Cytotoxicity and Antimicrobial .pdfPhytochemical Aspects, Cytotoxicity and Antimicrobial .pdfapplication/pdf337484https://www.arca.fiocruz.br/bitstream/icict/51131/2/Phytochemical%20Aspects%2c%20Cytotoxicity%20and%20Antimicrobial%20.pdfeea45dba269a3349410e900c645e301dMD52icict/511312022-02-10 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dc.title.pt_BR.fl_str_mv Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli
title Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli
spellingShingle Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli
Alcântara, Lorena Kimberly Silva
plant extract
uropathogenic E. coli
antimicrobial
umbu
seriguela
cupuaçu
title_short Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli
title_full Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli
title_fullStr Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli
title_full_unstemmed Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli
title_sort Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli
author Alcântara, Lorena Kimberly Silva
author_facet Alcântara, Lorena Kimberly Silva
Machado, Luiz Felipe Carreiro
Ceravolo, Isabela Penna
Santos, Renan Martins dos
Souza, Marcus Vinícius Dias
author_role author
author2 Machado, Luiz Felipe Carreiro
Ceravolo, Isabela Penna
Santos, Renan Martins dos
Souza, Marcus Vinícius Dias
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Alcântara, Lorena Kimberly Silva
Machado, Luiz Felipe Carreiro
Ceravolo, Isabela Penna
Santos, Renan Martins dos
Souza, Marcus Vinícius Dias
dc.subject.en.pt_BR.fl_str_mv plant extract
uropathogenic E. coli
antimicrobial
umbu
seriguela
cupuaçu
topic plant extract
uropathogenic E. coli
antimicrobial
umbu
seriguela
cupuaçu
description PharmBSc Program. Pitágoras College. Ipatinga, MG, Brazil/Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-10T13:09:57Z
dc.date.available.fl_str_mv 2022-02-10T13:09:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALCÂNTARA, Lorena Kimberly Silva et al. Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli. Biointerface Research in Applied Chemistry, v. 11, n. 1, p. 8210 – 8217, 2021. doi.org/10.33263/BRIAC111.82108217
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51131
dc.identifier.issn.pt_BR.fl_str_mv 2069-5837
identifier_str_mv ALCÂNTARA, Lorena Kimberly Silva et al. Phytochemical Aspects, Cytotoxicity and Antimicrobial Activity of the Methanolic Extract of Tropical Fruit Pulps on Clinical Isolates of Escherichia coli. Biointerface Research in Applied Chemistry, v. 11, n. 1, p. 8210 – 8217, 2021. doi.org/10.33263/BRIAC111.82108217
2069-5837
url https://www.arca.fiocruz.br/handle/icict/51131
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Resurchify
publisher.none.fl_str_mv Resurchify
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51131/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51131/2/Phytochemical%20Aspects%2c%20Cytotoxicity%20and%20Antimicrobial%20.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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