Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31602 |
Resumo: | Conselho Nacional de Pesquisas (CNPq), Coordenação do Curso de Graduação Pessoal (CAPES) e Instituto Aggeu Magalhães / Oswaldo ˜ Fundação Cruz (CPqAM-FIOCRUZ). |
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Silva, Eliete Cavalcanti daRayol, Cynthia DiasMedeiros, Paloma LysFigueiredo, Regina Célia Bressan QueirozPiuvezan, Márcia ReginaBrabosa-Filho, José MariaMarinho, Alexsandro FernandesSilva, Teresinha GonçalvesMilitão, Gardenia Carmen GadelhaCassilhas, Ana Paula PimentelAndrade, Paulo Paes de2019-02-13T14:46:04Z2019-02-13T14:46:04Z2012CAVALCANTI DA SILVA, Eliete et al. Antileishmanial Activity of Warifteine: A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos Sympodialis Eichl. (Menispermaceae). TheScientificWorldJournal, v. 2012, p. 516408, 2012.1537-744Xhttps://www.arca.fiocruz.br/handle/icict/3160210.1100/2012/516408Conselho Nacional de Pesquisas (CNPq), Coordenação do Curso de Graduação Pessoal (CAPES) e Instituto Aggeu Magalhães / Oswaldo ˜ Fundação Cruz (CPqAM-FIOCRUZ).Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Histologia e Embriologia. Recife, PE, Brasil.Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Histologia e Embriologia. Recife, PE, Brasil.Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Histologia e Embriologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. Joao Pessoa, PB, Brasil.Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. Joao Pessoa, PB, Brasil.Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. Joao Pessoa, PB, Brasil.Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Antibióticos. Recife, PE, Brasil.Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Antibióticos. Recife, PE, Brasil.Universidade Salgado de Oliveira. Departamento de Ensino de Enfermagem. Recife, PE, Brasil.Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Genética. Recife, PE, Brasil.Leishmania (L.) chagasi is the etiological agent of visceral leishmaniasis, an important endemic zoonosis in the American continent, as well as in many other countries in Asia, Africa, and Mediterranean Europe. The treatment is difficult due to the high toxicity of the available drugs, high costs, and emergence of resistance in the parasites. Therefore, there is an urgent need for new leishmanicidal agents. The bisbenzylisoquinoline alkaloids have been related to antibacterial, antiprotozoal, and antifungal activities. The aim of this study was to evaluate the growth inhibitory activity of warifteine (bisbenzylisoquinoline alkaloid) against L. chagasi promastigotes in axenic cultures and the occurrence of drug-induced ultrastructural changes in the parasite. This bisbenzylisoquinoline alkaloid was isolated from the leaves and roots of Cissampelos sympodialis Eichl. (Menispermaceae), a plant commonly used for the treatment of various diseases in Brazilian folk medicine. Using the purified warifteine, the 50% inhibitory concentration (IC₅₀) was determined at 0.08 mg/mL after 72 h in culture, inducing significant changes in the parasite morphology, like aberrant multisepted forms and blebs in the plasma membrane. In conclusion, warifteine represents an attractive candidate for future pharmacological studies aiming new leishmanicidal drugs.engAntileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAlcalóides / isolamento e purificaçãoAlcalóides / farmacologiaAntineoplásicos Fitogênicos / isolamento & purificaçãoAntineoplásicos Fitogênicos / FarmacologiaAgentes Antiprotozoários / isolamento & purificaçãoAgentes Antiprotozoários / farmacologiaCultura AxênicaBenzilisoquinolinas / isolamento e purificaçãoBenzilisoquinolinas / farmacologiaLinha Celular, TumorMembrana Celular / efeitos de drogasCissampelos / químicaAvaliação de Medicamentos Pré-ClínicosHumanosConcentração Inibidora 50Leishmania / efeitos de drogasLeishmania / ultraestruturaTestes de Sensibilidade MicrobianaMicroscopia, elétron, varreduraFolhas de plantas / químicaFatores de Tempoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae) |
| title |
Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae) |
| spellingShingle |
Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae) Silva, Eliete Cavalcanti da Alcalóides / isolamento e purificação Alcalóides / farmacologia Antineoplásicos Fitogênicos / isolamento & purificação Antineoplásicos Fitogênicos / Farmacologia Agentes Antiprotozoários / isolamento & purificação Agentes Antiprotozoários / farmacologia Cultura Axênica Benzilisoquinolinas / isolamento e purificação Benzilisoquinolinas / farmacologia Linha Celular, Tumor Membrana Celular / efeitos de drogas Cissampelos / química Avaliação de Medicamentos Pré-Clínicos Humanos Concentração Inibidora 50 Leishmania / efeitos de drogas Leishmania / ultraestrutura Testes de Sensibilidade Microbiana Microscopia, elétron, varredura Folhas de plantas / química Fatores de Tempo |
| title_short |
Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae) |
| title_full |
Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae) |
| title_fullStr |
Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae) |
| title_full_unstemmed |
Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae) |
| title_sort |
Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae) |
| author |
Silva, Eliete Cavalcanti da |
| author_facet |
Silva, Eliete Cavalcanti da Rayol, Cynthia Dias Medeiros, Paloma Lys Figueiredo, Regina Célia Bressan Queiroz Piuvezan, Márcia Regina Brabosa-Filho, José Maria Marinho, Alexsandro Fernandes Silva, Teresinha Gonçalves Militão, Gardenia Carmen Gadelha Cassilhas, Ana Paula Pimentel Andrade, Paulo Paes de |
| author_role |
author |
| author2 |
Rayol, Cynthia Dias Medeiros, Paloma Lys Figueiredo, Regina Célia Bressan Queiroz Piuvezan, Márcia Regina Brabosa-Filho, José Maria Marinho, Alexsandro Fernandes Silva, Teresinha Gonçalves Militão, Gardenia Carmen Gadelha Cassilhas, Ana Paula Pimentel Andrade, Paulo Paes de |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Eliete Cavalcanti da Rayol, Cynthia Dias Medeiros, Paloma Lys Figueiredo, Regina Célia Bressan Queiroz Piuvezan, Márcia Regina Brabosa-Filho, José Maria Marinho, Alexsandro Fernandes Silva, Teresinha Gonçalves Militão, Gardenia Carmen Gadelha Cassilhas, Ana Paula Pimentel Andrade, Paulo Paes de |
| dc.subject.decs.pt_BR.fl_str_mv |
Alcalóides / isolamento e purificação Alcalóides / farmacologia Antineoplásicos Fitogênicos / isolamento & purificação Antineoplásicos Fitogênicos / Farmacologia Agentes Antiprotozoários / isolamento & purificação Agentes Antiprotozoários / farmacologia Cultura Axênica Benzilisoquinolinas / isolamento e purificação Benzilisoquinolinas / farmacologia Linha Celular, Tumor Membrana Celular / efeitos de drogas Cissampelos / química Avaliação de Medicamentos Pré-Clínicos Humanos Concentração Inibidora 50 Leishmania / efeitos de drogas Leishmania / ultraestrutura Testes de Sensibilidade Microbiana Microscopia, elétron, varredura Folhas de plantas / química Fatores de Tempo |
| topic |
Alcalóides / isolamento e purificação Alcalóides / farmacologia Antineoplásicos Fitogênicos / isolamento & purificação Antineoplásicos Fitogênicos / Farmacologia Agentes Antiprotozoários / isolamento & purificação Agentes Antiprotozoários / farmacologia Cultura Axênica Benzilisoquinolinas / isolamento e purificação Benzilisoquinolinas / farmacologia Linha Celular, Tumor Membrana Celular / efeitos de drogas Cissampelos / química Avaliação de Medicamentos Pré-Clínicos Humanos Concentração Inibidora 50 Leishmania / efeitos de drogas Leishmania / ultraestrutura Testes de Sensibilidade Microbiana Microscopia, elétron, varredura Folhas de plantas / química Fatores de Tempo |
| description |
Conselho Nacional de Pesquisas (CNPq), Coordenação do Curso de Graduação Pessoal (CAPES) e Instituto Aggeu Magalhães / Oswaldo ˜ Fundação Cruz (CPqAM-FIOCRUZ). |
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2012 |
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2012 |
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2019-02-13T14:46:04Z |
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2019-02-13T14:46:04Z |
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CAVALCANTI DA SILVA, Eliete et al. Antileishmanial Activity of Warifteine: A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos Sympodialis Eichl. (Menispermaceae). TheScientificWorldJournal, v. 2012, p. 516408, 2012. |
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https://www.arca.fiocruz.br/handle/icict/31602 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1537-744X |
| dc.identifier.doi.none.fl_str_mv |
10.1100/2012/516408 |
| identifier_str_mv |
CAVALCANTI DA SILVA, Eliete et al. Antileishmanial Activity of Warifteine: A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos Sympodialis Eichl. (Menispermaceae). TheScientificWorldJournal, v. 2012, p. 516408, 2012. 1537-744X 10.1100/2012/516408 |
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eng |
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