Biological activities of Croton palanostigma Klotzsch
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/2828 |
Resumo: | Background: Different species of Croton are used in traditional Amazonian medicine. Among the popular uses are treatment of bacterial diseases, poorly healing wounds and fevers. Objective: This study evaluated the antileishmanial, antiplasmodial and antimicrobial activities of the extracts and diterpenes of Croton palanostigma Klotzsch (Euphorbiaceae). Materials and Methods: Leaves and bark were extracted with dichloromethane and methanol. The bark dichloromethane extract (BDE) was chromatographed on a column, obtaining cordatin and aparisthman. The extracts and diterpenes were assayed thought agar disk diffusion method and their bactericidal or fungicidal effects were evaluated by minimum bactericidal or fungicidal concentration. The antiplasmodial activity was evaluated after 24 and 72 h of exposition. The antileishmanial activity was performed on promastigotes forms of Leishmania amazonensis. Results: The bark methanol extract (BME) and cordatin were not active against any microbial strains tested; BDE and leaves methanol extract (LME) were positive for Pseudomonas aeruginosa and aparisthman was positive for Candida albicans. In the determination of the minimum bactericidal concentration, neither of them were active in the highest concentration tested. The extracts and diterpenes were inactive in Plasmodium falciparum, except the LME in 72 h. Any extract was shown to be active in promastigote forms of L. amazonensis. Conclusion: These results indicate that the BDE and LME did not inhibit the bacterial growth, then they probably had bacteriostatic effect. LME presented activity in P. falciparum. |
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Mota, Eduardo FerreiraRosario, Diele MagnoVeiga, Andreza Socorro SilvaBrasil, Davi do Socorro BarrosSilveira, Fernando TobiasDolabela, Maria Fâni2017-11-06T17:08:06Z2017-11-06T17:08:06Z2015MOTA, Eduardo Ferreira et al. Biological activities of Croton palanostigma Klotzsch. Pharmacognosy Magazine, v. 11, n. 43, p. 601-606, Jul-Sep. 2015. DOI: https://doi.org/10.4103/0973-1296.160449. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792008/pdf/PM-12-96.pdf0973-1296https://patua.iec.gov.br/handle/iec/282810.4103/0973-1296.160449Background: Different species of Croton are used in traditional Amazonian medicine. Among the popular uses are treatment of bacterial diseases, poorly healing wounds and fevers. Objective: This study evaluated the antileishmanial, antiplasmodial and antimicrobial activities of the extracts and diterpenes of Croton palanostigma Klotzsch (Euphorbiaceae). Materials and Methods: Leaves and bark were extracted with dichloromethane and methanol. The bark dichloromethane extract (BDE) was chromatographed on a column, obtaining cordatin and aparisthman. The extracts and diterpenes were assayed thought agar disk diffusion method and their bactericidal or fungicidal effects were evaluated by minimum bactericidal or fungicidal concentration. The antiplasmodial activity was evaluated after 24 and 72 h of exposition. The antileishmanial activity was performed on promastigotes forms of Leishmania amazonensis. Results: The bark methanol extract (BME) and cordatin were not active against any microbial strains tested; BDE and leaves methanol extract (LME) were positive for Pseudomonas aeruginosa and aparisthman was positive for Candida albicans. In the determination of the minimum bactericidal concentration, neither of them were active in the highest concentration tested. The extracts and diterpenes were inactive in Plasmodium falciparum, except the LME in 72 h. Any extract was shown to be active in promastigote forms of L. amazonensis. Conclusion: These results indicate that the BDE and LME did not inhibit the bacterial growth, then they probably had bacteriostatic effect. LME presented activity in P. falciparum.Federal University of Para. Institute of Biological Sciences. Post Graduation in Biology of Infectious and parasitary Agents. Belém, PA, Brazil.Federal University of Para. Faculty of Pharmaceutical Sciences. Institute of Health Sciences. Belém, PA, Brazil.Federal University of Para. Institute of Health Sciences. Post Graduation in Pharmaceutical Sciences. Belém , PA, Brazil.Federal University of Para. Institute of Technology. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Para. Institute of Health Sciences. Post Graduation in Pharmaceutical Sciences. Belém , PA, BrazilengPharmacognosy Network WorldwideBiological activities of Croton palanostigma Klotzschinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAntiprotozoários / isolamento & purificaçãoAntiprotozoários / farmacologiaAntifúngicos / farmacologiaAntibacterianos / farmacologiaCroton / químicaDiterpenosExtratos Vegetais / químicaExtratos Vegetais / toxicidadeLeishmania / efeitos de drogasinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECLICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/febdd8de-a6b6-4b52-92d3-cbe9bd1b2f90/download52f1732ea66fbd1123abe39f5373b797MD52TEXTBiological activities of Croton palanostigma Klotzsch.pdf.txtBiological activities of Croton palanostigma Klotzsch.pdf.txtExtracted texttext/plain28052https://patua.iec.gov.br/bitstreams/23d91218-ba60-46f8-b30d-e6cf259871c1/download5d0136a637fd6a51808dc994bfd4923dMD56THUMBNAILBiological activities of Croton palanostigma Klotzsch.pdf.jpgBiological activities of Croton palanostigma Klotzsch.pdf.jpgGenerated Thumbnailimage/jpeg6094https://patua.iec.gov.br/bitstreams/794dd304-e4eb-40d9-8943-237695d8a3fd/download6417f2d2610f3de7e4ae10f2bfe88707MD57ORIGINALBiological activities of Croton palanostigma Klotzsch.pdfBiological activities of Croton palanostigma Klotzsch.pdfapplication/pdf1231257https://patua.iec.gov.br/bitstreams/b83d97ee-7c0d-4371-a7c0-4dcce8803aad/downloadf197b88eb488dda96882e2899f5ec745MD55iec/28282023-06-13 17:39:48.239oai:patua.iec.gov.br:iec/2828https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-06-13T17:39:48Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Biological activities of Croton palanostigma Klotzsch |
title |
Biological activities of Croton palanostigma Klotzsch |
spellingShingle |
Biological activities of Croton palanostigma Klotzsch Mota, Eduardo Ferreira Antiprotozoários / isolamento & purificação Antiprotozoários / farmacologia Antifúngicos / farmacologia Antibacterianos / farmacologia Croton / química Diterpenos Extratos Vegetais / química Extratos Vegetais / toxicidade Leishmania / efeitos de drogas |
title_short |
Biological activities of Croton palanostigma Klotzsch |
title_full |
Biological activities of Croton palanostigma Klotzsch |
title_fullStr |
Biological activities of Croton palanostigma Klotzsch |
title_full_unstemmed |
Biological activities of Croton palanostigma Klotzsch |
title_sort |
Biological activities of Croton palanostigma Klotzsch |
author |
Mota, Eduardo Ferreira |
author_facet |
Mota, Eduardo Ferreira Rosario, Diele Magno Veiga, Andreza Socorro Silva Brasil, Davi do Socorro Barros Silveira, Fernando Tobias Dolabela, Maria Fâni |
author_role |
author |
author2 |
Rosario, Diele Magno Veiga, Andreza Socorro Silva Brasil, Davi do Socorro Barros Silveira, Fernando Tobias Dolabela, Maria Fâni |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Mota, Eduardo Ferreira Rosario, Diele Magno Veiga, Andreza Socorro Silva Brasil, Davi do Socorro Barros Silveira, Fernando Tobias Dolabela, Maria Fâni |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Antiprotozoários / isolamento & purificação Antiprotozoários / farmacologia Antifúngicos / farmacologia Antibacterianos / farmacologia Croton / química Diterpenos Extratos Vegetais / química Extratos Vegetais / toxicidade Leishmania / efeitos de drogas |
topic |
Antiprotozoários / isolamento & purificação Antiprotozoários / farmacologia Antifúngicos / farmacologia Antibacterianos / farmacologia Croton / química Diterpenos Extratos Vegetais / química Extratos Vegetais / toxicidade Leishmania / efeitos de drogas |
description |
Background: Different species of Croton are used in traditional Amazonian medicine. Among the popular uses are treatment of bacterial diseases, poorly healing wounds and fevers. Objective: This study evaluated the antileishmanial, antiplasmodial and antimicrobial activities of the extracts and diterpenes of Croton palanostigma Klotzsch (Euphorbiaceae). Materials and Methods: Leaves and bark were extracted with dichloromethane and methanol. The bark dichloromethane extract (BDE) was chromatographed on a column, obtaining cordatin and aparisthman. The extracts and diterpenes were assayed thought agar disk diffusion method and their bactericidal or fungicidal effects were evaluated by minimum bactericidal or fungicidal concentration. The antiplasmodial activity was evaluated after 24 and 72 h of exposition. The antileishmanial activity was performed on promastigotes forms of Leishmania amazonensis. Results: The bark methanol extract (BME) and cordatin were not active against any microbial strains tested; BDE and leaves methanol extract (LME) were positive for Pseudomonas aeruginosa and aparisthman was positive for Candida albicans. In the determination of the minimum bactericidal concentration, neither of them were active in the highest concentration tested. The extracts and diterpenes were inactive in Plasmodium falciparum, except the LME in 72 h. Any extract was shown to be active in promastigote forms of L. amazonensis. Conclusion: These results indicate that the BDE and LME did not inhibit the bacterial growth, then they probably had bacteriostatic effect. LME presented activity in P. falciparum. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2017-11-06T17:08:06Z |
dc.date.available.fl_str_mv |
2017-11-06T17:08:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MOTA, Eduardo Ferreira et al. Biological activities of Croton palanostigma Klotzsch. Pharmacognosy Magazine, v. 11, n. 43, p. 601-606, Jul-Sep. 2015. DOI: https://doi.org/10.4103/0973-1296.160449. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792008/pdf/PM-12-96.pdf |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/2828 |
dc.identifier.issn.-.fl_str_mv |
0973-1296 |
dc.identifier.doi.-.fl_str_mv |
10.4103/0973-1296.160449 |
identifier_str_mv |
MOTA, Eduardo Ferreira et al. Biological activities of Croton palanostigma Klotzsch. Pharmacognosy Magazine, v. 11, n. 43, p. 601-606, Jul-Sep. 2015. DOI: https://doi.org/10.4103/0973-1296.160449. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792008/pdf/PM-12-96.pdf 0973-1296 10.4103/0973-1296.160449 |
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https://patua.iec.gov.br/handle/iec/2828 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Pharmacognosy Network Worldwide |
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Pharmacognosy Network Worldwide |
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