γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends

Detalhes bibliográficos
Autor(a) principal: Barros, Mateus de Souza
Data de Publicação: 2021
Outros Autores: Araújo, Nilberto Dias de, Gama, Fábio Magalhães, Ribeiro, Thaís Lohana Pereira, Hanna, Fabíola Silva Alves, Tarragô, Andréa Monteiro, Malheiro, Adriana, Costa, Allyson Guimarães
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53129
Resumo: Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil
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spelling Barros, Mateus de SouzaAraújo, Nilberto Dias deGama, Fábio MagalhãesRibeiro, Thaís Lohana PereiraHanna, Fabíola Silva AlvesTarragô, Andréa MonteiroMalheiro, AdrianaCosta, Allyson Guimarães2022-06-08T18:45:32Z2022-06-08T18:45:32Z2021BARROS, Mateus de Souza et al. γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends. Front Immunol., v. 12, 729085, 2021. doi: 10.3389/fimmu.2021.729085.1664-3224https://www.arca.fiocruz.br/handle/icict/5312910.3389/fimmu.2021.729085engFrontiers Media S.A.γδ T Cells for Leukemia Immunotherapy: New and Expanding Trendsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil/Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil/Escola de Enfermagem de Manaus, UFAM, Manaus, BrazilRecently, many discoveries have elucidated the cellular and molecular diversity in the leukemic microenvironment and improved our knowledge regarding their complex nature. This has allowed the development of new therapeutic strategies against leukemia. Advances in biotechnology and the current understanding of T cell-engineering have led to new approaches in this fight, thus improving cell-mediated immune response against cancer. However, most of the investigations focus only on conventional cytotoxic cells, while ignoring the potential of unconventional T cells that until now have been little studied. gd T cells are a unique lymphocyte subpopulation that has an extensive repertoire of tumor sensing and may have new immunotherapeutic applications in a wide range of tumors. The ability to respond regardless of human leukocyte antigen (HLA) expression, the secretion of antitumor mediators and high functional plasticity are hallmarks of gd T cells, and are ones that make them a promising alternative in the field of cell therapy. Despite this situation, in particular cases, the leukemic microenvironment can adopt strategies to circumvent the antitumor response of these lymphocytes, causing their exhaustion or polarization to a tumor-promoting phenotype. Intervening in this crosstalk can improve their capabilities and clinical applications and can make them key components in new therapeutic antileukemic approaches. In this review, we highlight several characteristics of gd T cells and their interactions in leukemia. Furthermore, we explore strategies for maximizing their antitumor functions, aiming to illustrate the findings destined for a better mobilization of gd T cells against the tumor. Finally, we outline our perspectives on their therapeutic applicability and indicate outstanding issues for future basic and clinical leukemia research, in the hope of contributing to the advancement of studies on gd T cells in cancer immunotherapy.gamma-delta T cellsleukemic microenvironmentoff-the-shelf cell therapyclinical trialscell transplantationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/53129/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALGamma T cells.pdfGamma T cells.pdfapplication/pdf35989655https://www.arca.fiocruz.br/bitstream/icict/53129/2/Gamma%20T%20cells.pdfd35d1ed84dc7f4070104e82bf1012200MD52icict/531292022-06-08 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dc.title.pt_BR.fl_str_mv γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
title γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
spellingShingle γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
Barros, Mateus de Souza
gamma-delta T cells
leukemic microenvironment
off-the-shelf cell therapy
clinical trials
cell transplantation
title_short γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
title_full γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
title_fullStr γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
title_full_unstemmed γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
title_sort γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
author Barros, Mateus de Souza
author_facet Barros, Mateus de Souza
Araújo, Nilberto Dias de
Gama, Fábio Magalhães
Ribeiro, Thaís Lohana Pereira
Hanna, Fabíola Silva Alves
Tarragô, Andréa Monteiro
Malheiro, Adriana
Costa, Allyson Guimarães
author_role author
author2 Araújo, Nilberto Dias de
Gama, Fábio Magalhães
Ribeiro, Thaís Lohana Pereira
Hanna, Fabíola Silva Alves
Tarragô, Andréa Monteiro
Malheiro, Adriana
Costa, Allyson Guimarães
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barros, Mateus de Souza
Araújo, Nilberto Dias de
Gama, Fábio Magalhães
Ribeiro, Thaís Lohana Pereira
Hanna, Fabíola Silva Alves
Tarragô, Andréa Monteiro
Malheiro, Adriana
Costa, Allyson Guimarães
dc.subject.en.pt_BR.fl_str_mv gamma-delta T cells
leukemic microenvironment
off-the-shelf cell therapy
clinical trials
cell transplantation
topic gamma-delta T cells
leukemic microenvironment
off-the-shelf cell therapy
clinical trials
cell transplantation
description Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-06-08T18:45:32Z
dc.date.available.fl_str_mv 2022-06-08T18:45:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARROS, Mateus de Souza et al. γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends. Front Immunol., v. 12, 729085, 2021. doi: 10.3389/fimmu.2021.729085.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53129
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2021.729085
identifier_str_mv BARROS, Mateus de Souza et al. γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends. Front Immunol., v. 12, 729085, 2021. doi: 10.3389/fimmu.2021.729085.
1664-3224
10.3389/fimmu.2021.729085
url https://www.arca.fiocruz.br/handle/icict/53129
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53129/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53129/2/Gamma%20T%20cells.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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