From thymus to periphery: molecular basis of effector γδ‐T cell differentiation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.21/12413 |
Resumo: | H2020 European Research Council. Grant Number: CoG_676401. European Commission Marie Sklodowska‐Curie Individual Fellowship. Grant Number: 752932. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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From thymus to periphery: molecular basis of effector γδ‐T cell differentiationEffector T cell differentiationGamma-delta T cellsIL-17Thymic T cell developmentH2020 European Research Council. Grant Number: CoG_676401. European Commission Marie Sklodowska‐Curie Individual Fellowship. Grant Number: 752932.The contributions of γδ T cells to immune (patho)physiology in many pre-clinical mouse models have been associated with their rapid and abundant provision of two critical cytokines, interferon-γ (IFN-γ) and interleukin-17A (IL-17). These are typically produced by distinct effector γδ T cell subsets that can be segregated on the basis of surface expression levels of receptors such as CD27, CD44, or CD45RB, among others. Unlike conventional T cells that egress the thymus as naïve lymphocytes awaiting further differentiation upon activation, a large fraction of murine γδ T cells commits to either IFN-γ or IL-17 expression during thymic development. However, extrathymic signals can both regulate pre-programmed γδ T cells; and induce peripheral differentiation of naïve γδ T cells into effectors. Here we review the key cellular events of "developmental pre-programming" in the mouse thymus; and the molecular basis for effector function maintenance vs plasticity in the periphery. We highlight some of our contributions towards elucidating the role of T cell receptor, co-receptors (like CD27 and CD28) and cytokine signals (such as IL-1β and IL-23) in these processes, and the various levels of gene regulation involved, from the chromatin landscape to microRNA-based post-transcriptional control of γδ T cell functional plasticity.WileyRCIPLFiala, Gina J.Gomes, Anita Q.Silva‐Santos, Bruno2020-12-04T21:50:37Z2020-112020-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/12413engFiala GJ, Gomes AQ, Silva-Santos B. From thymus to periphery: molecular basis of effector γδ‐T cell differentiation. Immunol Rev. 2020;298(1):47-60.10.1111/imr.12918info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:05:17Zoai:repositorio.ipl.pt:10400.21/12413Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:20:30.372457Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation |
| title |
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation |
| spellingShingle |
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation Fiala, Gina J. Effector T cell differentiation Gamma-delta T cells IL-17 Thymic T cell development |
| title_short |
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation |
| title_full |
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation |
| title_fullStr |
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation |
| title_full_unstemmed |
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation |
| title_sort |
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation |
| author |
Fiala, Gina J. |
| author_facet |
Fiala, Gina J. Gomes, Anita Q. Silva‐Santos, Bruno |
| author_role |
author |
| author2 |
Gomes, Anita Q. Silva‐Santos, Bruno |
| author2_role |
author author |
| dc.contributor.none.fl_str_mv |
RCIPL |
| dc.contributor.author.fl_str_mv |
Fiala, Gina J. Gomes, Anita Q. Silva‐Santos, Bruno |
| dc.subject.por.fl_str_mv |
Effector T cell differentiation Gamma-delta T cells IL-17 Thymic T cell development |
| topic |
Effector T cell differentiation Gamma-delta T cells IL-17 Thymic T cell development |
| description |
H2020 European Research Council. Grant Number: CoG_676401. European Commission Marie Sklodowska‐Curie Individual Fellowship. Grant Number: 752932. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12-04T21:50:37Z 2020-11 2020-11-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/12413 |
| url |
http://hdl.handle.net/10400.21/12413 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Fiala GJ, Gomes AQ, Silva-Santos B. From thymus to periphery: molecular basis of effector γδ‐T cell differentiation. Immunol Rev. 2020;298(1):47-60. 10.1111/imr.12918 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133474299314176 |