Molecular determinants of target cell recognition by human γδ T Cells

Detalhes bibliográficos
Autor(a) principal: Simões, André
Data de Publicação: 2018
Outros Autores: Di Lorenzo, Biagio, Silva-Santos, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49059
Resumo: Copyright: © 2018 Simões, Di Lorenzo and Silva-Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Molecular determinants of target cell recognition by human γδ T CellsNK cell receptorNKG2DT cell receptorGamma-delta T cellTumor immunologyCopyright: © 2018 Simões, Di Lorenzo and Silva-Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a mechanistic standpoint, numerous studies have unveiled a remarkable flexibility of γδ T cells in employing their T cell receptor and/or NK cell receptors for target cell recognition, even if the relevant ligands often remain uncertain. Here, we review the accumulated knowledge on the diverse mechanisms of target cell recognition by γδ T cells, focusing on human γδ T cells, to provide an integrated perspective of their therapeutic potential in cancer and infectious diseases.We acknowledge funding from Fundação para a Ciência e a Tecnologia (PTDC/DTP-PIC/4931/2014 to BS-S; and PD/BD/105880/2014 to BL). This publication was sponsored by LISBOA-01-0145-FEDER-007391, project cofunded by FEDER, through POR Lisboa 2020—Programa Operacional Regional de Lisboa, PORTUGAL 2020, and Fundação para a Ciência e a Tecnologia.FrontiersRepositório da Universidade de LisboaSimões, AndréDi Lorenzo, BiagioSilva-Santos, Bruno2021-07-22T15:01:42Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49059engFront Immunol. 2018 Apr 27;9:929.10.3389/fimmu.2018.009291664-3224info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:21Zoai:repositorio.ul.pt:10451/49059Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:36.537977Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Molecular determinants of target cell recognition by human γδ T Cells
title Molecular determinants of target cell recognition by human γδ T Cells
spellingShingle Molecular determinants of target cell recognition by human γδ T Cells
Simões, André
NK cell receptor
NKG2D
T cell receptor
Gamma-delta T cell
Tumor immunology
title_short Molecular determinants of target cell recognition by human γδ T Cells
title_full Molecular determinants of target cell recognition by human γδ T Cells
title_fullStr Molecular determinants of target cell recognition by human γδ T Cells
title_full_unstemmed Molecular determinants of target cell recognition by human γδ T Cells
title_sort Molecular determinants of target cell recognition by human γδ T Cells
author Simões, André
author_facet Simões, André
Di Lorenzo, Biagio
Silva-Santos, Bruno
author_role author
author2 Di Lorenzo, Biagio
Silva-Santos, Bruno
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Simões, André
Di Lorenzo, Biagio
Silva-Santos, Bruno
dc.subject.por.fl_str_mv NK cell receptor
NKG2D
T cell receptor
Gamma-delta T cell
Tumor immunology
topic NK cell receptor
NKG2D
T cell receptor
Gamma-delta T cell
Tumor immunology
description Copyright: © 2018 Simões, Di Lorenzo and Silva-Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2021-07-22T15:01:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49059
url http://hdl.handle.net/10451/49059
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Immunol. 2018 Apr 27;9:929.
10.3389/fimmu.2018.00929
1664-3224
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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