Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis

Detalhes bibliográficos
Autor(a) principal: Lago, Tainã
Data de Publicação: 2021
Outros Autores: Carvalho, Lucas P., Nascimento, Mauricio, Guimarães, Luiz H., Lago, Jamile, Castellucci, Léa, Carvalho, Augusto M., Lago, Alex, Carvalho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49860
Resumo: Brazilian Ministry of Science, Technology, and Innovation; the Brazilian Research Council (CNPq); and the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
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spelling Lago, TainãCarvalho, Lucas P.Nascimento, MauricioGuimarães, Luiz H.Lago, JamileCastellucci, LéaCarvalho, Augusto M.Lago, AlexCarvalho, Edgar Marcelino de2021-11-17T17:57:38Z2021-11-17T17:57:38Z2021LAGO, Tainã et al. Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Clinical Infectious Diseases, 2021.1058-4838https://www.arca.fiocruz.br/handle/icict/4986010.1093/cid/ciab236Brazilian Ministry of Science, Technology, and Innovation; the Brazilian Research Council (CNPq); and the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil.Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Federal University of Southern Bahia. Teixeira de Freitas, BA, Brazil.Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil.Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil.Federal University of Bahia. Professor Edgard Santos University Hospital Complex. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia Medical School. Postgraduate Course in Health Sciences, Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Background. Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a single ulcer or multiple cutaneous lesions with raised borders. Cure rates <60% are observed in response to meglumine antimoniate therapy. We investigated the impact of obesity on CL clinical presentation and therapeutic response. Methods. A total of 90 age-matched patients with CL were included (30 obese, 30 overweight, and 30 with normal body mass index [BMI]). CL was diagnosed through documentation of L. braziliensis DNA by polymerase chain reaction or identification of amastigotes in biopsied skin-lesion samples. Serum cytokine levels were determined by chemiluminescence. Antimony therapy with Glucantime (Sanofi-Aventis; 20 mg/kg/day) was administered for 20 days. Results. Obese CL patients may present hypertrophic ulcers rather than typical oval, ulcerated lesions. A direct correlation between BMI and healing time was noted. After 1 course of antimony, cure was achieved in 73% of patients with normal BMI, 37% of overweight subjects, yet just 18% of obese CL patients (P < .01). Obese CL cases additionally presented higher leptin levels than overweight patients or those with normal BMI (P < .05). Conclusions. Obesity modifies the clinical presentation of CL and host immune response and is associated with greater failure to therapy.engOxford University PressLeishmaniose cutâneaLeishmania braziliensisObesidadeLesões atípicasResposta imune.cutaneous Leishmaniasis;Leishmania braziliensisObesityAtypical lesionsImmune response.Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49860/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALLago, Taina Influence....pdfLago, Taina Influence....pdfapplication/pdf7564650https://www.arca.fiocruz.br/bitstream/icict/49860/2/Lago%2c%20Taina%20Influence....pdf73b143427224fcf7ef2b8ea75a15964fMD52icict/498602023-03-15 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dc.title.pt_BR.fl_str_mv Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis
title Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis
spellingShingle Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis
Lago, Tainã
Leishmaniose cutânea
Leishmania braziliensis
Obesidade
Lesões atípicas
Resposta imune.
cutaneous Leishmaniasis;
Leishmania braziliensis
Obesity
Atypical lesions
Immune response.
title_short Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis
title_full Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis
title_fullStr Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis
title_full_unstemmed Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis
title_sort Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis
author Lago, Tainã
author_facet Lago, Tainã
Carvalho, Lucas P.
Nascimento, Mauricio
Guimarães, Luiz H.
Lago, Jamile
Castellucci, Léa
Carvalho, Augusto M.
Lago, Alex
Carvalho, Edgar Marcelino de
author_role author
author2 Carvalho, Lucas P.
Nascimento, Mauricio
Guimarães, Luiz H.
Lago, Jamile
Castellucci, Léa
Carvalho, Augusto M.
Lago, Alex
Carvalho, Edgar Marcelino de
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lago, Tainã
Carvalho, Lucas P.
Nascimento, Mauricio
Guimarães, Luiz H.
Lago, Jamile
Castellucci, Léa
Carvalho, Augusto M.
Lago, Alex
Carvalho, Edgar Marcelino de
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutânea
Leishmania braziliensis
Obesidade
Lesões atípicas
Resposta imune.
topic Leishmaniose cutânea
Leishmania braziliensis
Obesidade
Lesões atípicas
Resposta imune.
cutaneous Leishmaniasis;
Leishmania braziliensis
Obesity
Atypical lesions
Immune response.
dc.subject.en.pt_BR.fl_str_mv cutaneous Leishmaniasis;
Leishmania braziliensis
Obesity
Atypical lesions
Immune response.
description Brazilian Ministry of Science, Technology, and Innovation; the Brazilian Research Council (CNPq); and the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-17T17:57:38Z
dc.date.available.fl_str_mv 2021-11-17T17:57:38Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LAGO, Tainã et al. Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Clinical Infectious Diseases, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49860
dc.identifier.issn.pt_BR.fl_str_mv 1058-4838
dc.identifier.doi.none.fl_str_mv 10.1093/cid/ciab236
identifier_str_mv LAGO, Tainã et al. Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Clinical Infectious Diseases, 2021.
1058-4838
10.1093/cid/ciab236
url https://www.arca.fiocruz.br/handle/icict/49860
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49860/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49860/2/Lago%2c%20Taina%20Influence....pdf
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