Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.

Detalhes bibliográficos
Autor(a) principal: Silva, Edinete Melo da
Data de Publicação: 2004
Outros Autores: Santos, Claudio Cesar Cirne, Frugulhetti, Izabel C. P. P, Castro Filho, Bernardo Galvão, Saraiva, Elvira Maria B, Keuhne, Martin E, Bou-Habib, Dumith Chequer
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8134
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
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spelling Silva, Edinete Melo daSantos, Claudio Cesar CirneFrugulhetti, Izabel C. P. PCastro Filho, Bernardo GalvãoSaraiva, Elvira Maria BKeuhne, Martin EBou-Habib, Dumith Chequer2014-08-05T17:35:18Z2014-08-05T17:35:18Z2004SILVA, E. M. et al. Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine. Planta Medica, v. 70, n. 9, p. 808-812, 2004.0032-0943https://www.arca.fiocruz.br/handle/icict/813410.1055/s-2004-827227engGeorg Thieme Verlag KG StuttgartAnti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilUniversidade Federal Fluminense. Laboratório de Virologia Molecular. Departamento de Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil / Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilUniversidade Federal Fluminense. Laboratório de Virologia Molecular. Departamento de Biologia Celular e Molecular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilUniversity of Vermont. Department of Chemistry. Burlington, VT, USAInstituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilThe Iboga alkaloid congener 18-methoxycoronaridine (18-MC) exhibits in vitro leishmanicidal and in vivo anti-addiction properties. In this paper, we describe that 18-MC inhibits HIV-1 infection in human peripheral blood mononuclear cells (PBMCs) and monocyte-derived macrophages. We found that 18-MC inhibits the replication of primary isolates of HIV-1 in a dose-dependent manner, regardless of the preferential chemokine receptor usage of the isolates, at non-cell-toxic concentrations. The antiretroviral activity of 18-MC resulted in EC (50) values of 22.5 +/- 4.7 microM and 23 +/- 4.5 microM for R5 and X4 isolates, respectively, in PBMCs, and a therapeutic index (TI) of 14.5. Similar findings were observed for inhibition of HIV-1 replication in macrophages: EC (50) equal to 12.8 +/- 5 microM and 9.5 +/- 3 microM for an R5 virus after 14 and 21 days of infection, respectively, with TI equal to 25.6 and 34.5. 18-MC moderately inhibits the HIV-1 enzyme reverse transcriptase (IC (50) = 69.4 microM), which at least partially explains its antiretroviral activity.HIV-1Aids18-methoxycoronaridineIboga alkaloidReverse transcriptaseFármacos Anti-HIV/farmacologiaHIV-1/efeitos de drogasIbogaína/análogos & derivadosIbogaína/farmacologiaFitoterapiaTabernaemontanaFármacos Anti-HIV/administração & dosagemFármacos Anti-HIV/uso terapêuticoRelação Dose-Resposta a DrogaHumanosIbogaína/administração & dosagemIbogaína/uso terapêuticoLeucócitos Mononucleares/virologiaExtratos Vegetais/administração & dosagemExtratos Vegetais/farmacologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSilva EM Anti-HIV....pdfSilva EM Anti-HIV....pdfapplication/pdf197976https://www.arca.fiocruz.br/bitstream/icict/8134/1/Silva%20EM%20Anti-HIV....pdf572839340f28382b8e5a79474f73930cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8134/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSilva EM Anti-HIV....pdf.txtSilva EM Anti-HIV....pdf.txtExtracted texttext/plain23626https://www.arca.fiocruz.br/bitstream/icict/8134/3/Silva%20EM%20Anti-HIV....pdf.txt5b92cf076be8b7c9c27c83514eae8893MD53icict/81342023-03-15 14:33:23.003oai:www.arca.fiocruz.br:icict/8134TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.
title Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.
spellingShingle Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.
Silva, Edinete Melo da
HIV-1
Aids
18-methoxycoronaridine
Iboga alkaloid
Reverse transcriptase
Fármacos Anti-HIV/farmacologia
HIV-1/efeitos de drogas
Ibogaína/análogos & derivados
Ibogaína/farmacologia
Fitoterapia
Tabernaemontana
Fármacos Anti-HIV/administração & dosagem
Fármacos Anti-HIV/uso terapêutico
Relação Dose-Resposta a Droga
Humanos
Ibogaína/administração & dosagem
Ibogaína/uso terapêutico
Leucócitos Mononucleares/virologia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
title_short Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.
title_full Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.
title_fullStr Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.
title_full_unstemmed Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.
title_sort Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.
author Silva, Edinete Melo da
author_facet Silva, Edinete Melo da
Santos, Claudio Cesar Cirne
Frugulhetti, Izabel C. P. P
Castro Filho, Bernardo Galvão
Saraiva, Elvira Maria B
Keuhne, Martin E
Bou-Habib, Dumith Chequer
author_role author
author2 Santos, Claudio Cesar Cirne
Frugulhetti, Izabel C. P. P
Castro Filho, Bernardo Galvão
Saraiva, Elvira Maria B
Keuhne, Martin E
Bou-Habib, Dumith Chequer
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Edinete Melo da
Santos, Claudio Cesar Cirne
Frugulhetti, Izabel C. P. P
Castro Filho, Bernardo Galvão
Saraiva, Elvira Maria B
Keuhne, Martin E
Bou-Habib, Dumith Chequer
dc.subject.en.pt_BR.fl_str_mv HIV-1
Aids
18-methoxycoronaridine
Iboga alkaloid
Reverse transcriptase
topic HIV-1
Aids
18-methoxycoronaridine
Iboga alkaloid
Reverse transcriptase
Fármacos Anti-HIV/farmacologia
HIV-1/efeitos de drogas
Ibogaína/análogos & derivados
Ibogaína/farmacologia
Fitoterapia
Tabernaemontana
Fármacos Anti-HIV/administração & dosagem
Fármacos Anti-HIV/uso terapêutico
Relação Dose-Resposta a Droga
Humanos
Ibogaína/administração & dosagem
Ibogaína/uso terapêutico
Leucócitos Mononucleares/virologia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
dc.subject.decs.pt_BR.fl_str_mv Fármacos Anti-HIV/farmacologia
HIV-1/efeitos de drogas
Ibogaína/análogos & derivados
Ibogaína/farmacologia
Fitoterapia
Tabernaemontana
Fármacos Anti-HIV/administração & dosagem
Fármacos Anti-HIV/uso terapêutico
Relação Dose-Resposta a Droga
Humanos
Ibogaína/administração & dosagem
Ibogaína/uso terapêutico
Leucócitos Mononucleares/virologia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2014-08-05T17:35:18Z
dc.date.available.fl_str_mv 2014-08-05T17:35:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, E. M. et al. Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine. Planta Medica, v. 70, n. 9, p. 808-812, 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8134
dc.identifier.issn.none.fl_str_mv 0032-0943
dc.identifier.doi.none.fl_str_mv 10.1055/s-2004-827227
identifier_str_mv SILVA, E. M. et al. Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine. Planta Medica, v. 70, n. 9, p. 808-812, 2004.
0032-0943
10.1055/s-2004-827227
url https://www.arca.fiocruz.br/handle/icict/8134
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Georg Thieme Verlag KG Stuttgart
publisher.none.fl_str_mv Georg Thieme Verlag KG Stuttgart
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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