Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/187736 |
Resumo: | Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide (KI). Treatment-naïve cats with culture-confirmed sporotrichosis and presenting skin ulcers were treated for up to 40 weeks with oral ITZ alone (n = 74) or combined with KI (n = 56). These cats were submitted to monthly sampling of the same lesion for mycological culture and cytopathology until healing of lesion or up to twelve weeks. The fungal burden was expressed as the mean yeast cell count in three microscopic fields from imprint smears. The fungal burden before treatment was significantly higher in cats in which the lesion persisted and in cases of treatment failure when using ITZ alone. After twelve weeks, the median fungal burden decreased to zero in both treatment protocols, suggesting a potential decrease in the risk of transmission of Sporothrix spp. from cats. These findings encourage the early treatment of feline sporotrichosis as a control measure. Moreover, the fungal burden in feline sporotrichosis lesions can be a prognostic indicator and a parameter for choosing appropriate therapeutic regimen. |
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Miranda, Luisa H. M.Silva, Jéssica NunesGremião, Isabella D. F.Menezes, Rodrigo CaldasPaes, Rodrigo de AlmeidaReis, Érica Guerino dosOliveira, Raquel Vasconcellos Carvalhaes deAraujo, Danuza Salles do Amaral deFerreiro, LaertePereira, Sandro Antônio2019-01-12T04:22:52Z20182309-608Xhttp://hdl.handle.net/10183/187736001084096Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide (KI). Treatment-naïve cats with culture-confirmed sporotrichosis and presenting skin ulcers were treated for up to 40 weeks with oral ITZ alone (n = 74) or combined with KI (n = 56). These cats were submitted to monthly sampling of the same lesion for mycological culture and cytopathology until healing of lesion or up to twelve weeks. The fungal burden was expressed as the mean yeast cell count in three microscopic fields from imprint smears. The fungal burden before treatment was significantly higher in cats in which the lesion persisted and in cases of treatment failure when using ITZ alone. After twelve weeks, the median fungal burden decreased to zero in both treatment protocols, suggesting a potential decrease in the risk of transmission of Sporothrix spp. from cats. These findings encourage the early treatment of feline sporotrichosis as a control measure. Moreover, the fungal burden in feline sporotrichosis lesions can be a prognostic indicator and a parameter for choosing appropriate therapeutic regimen.application/pdfengJournal of Fungi. Basel. Vol. 4, no. 3 (Sept. 2018), 92, 11 p.Lesões cutâneasEsporotricoseFelinosItraconazolIodeto de potássioContagem de colônia microbianaViabilidade microbianaSporotrichosisCatFungal burdenItraconazolePotassium iodideMonitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment responseEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001084096.pdf.txt001084096.pdf.txtExtracted Texttext/plain38026http://www.lume.ufrgs.br/bitstream/10183/187736/2/001084096.pdf.txt6abd6b66a057c0572f763370f11b7533MD52ORIGINAL001084096.pdfTexto completo (inglês)application/pdf269386http://www.lume.ufrgs.br/bitstream/10183/187736/1/001084096.pdf106af8f928585b9bef35735da1bf9184MD5110183/1877362019-01-13 04:08:38.061211oai:www.lume.ufrgs.br:10183/187736Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-01-13T06:08:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
spellingShingle |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response Miranda, Luisa H. M. Lesões cutâneas Esporotricose Felinos Itraconazol Iodeto de potássio Contagem de colônia microbiana Viabilidade microbiana Sporotrichosis Cat Fungal burden Itraconazole Potassium iodide |
title_short |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title_full |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title_fullStr |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title_full_unstemmed |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title_sort |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
author |
Miranda, Luisa H. M. |
author_facet |
Miranda, Luisa H. M. Silva, Jéssica Nunes Gremião, Isabella D. F. Menezes, Rodrigo Caldas Paes, Rodrigo de Almeida Reis, Érica Guerino dos Oliveira, Raquel Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral de Ferreiro, Laerte Pereira, Sandro Antônio |
author_role |
author |
author2 |
Silva, Jéssica Nunes Gremião, Isabella D. F. Menezes, Rodrigo Caldas Paes, Rodrigo de Almeida Reis, Érica Guerino dos Oliveira, Raquel Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral de Ferreiro, Laerte Pereira, Sandro Antônio |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Miranda, Luisa H. M. Silva, Jéssica Nunes Gremião, Isabella D. F. Menezes, Rodrigo Caldas Paes, Rodrigo de Almeida Reis, Érica Guerino dos Oliveira, Raquel Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral de Ferreiro, Laerte Pereira, Sandro Antônio |
dc.subject.por.fl_str_mv |
Lesões cutâneas Esporotricose Felinos Itraconazol Iodeto de potássio Contagem de colônia microbiana Viabilidade microbiana |
topic |
Lesões cutâneas Esporotricose Felinos Itraconazol Iodeto de potássio Contagem de colônia microbiana Viabilidade microbiana Sporotrichosis Cat Fungal burden Itraconazole Potassium iodide |
dc.subject.eng.fl_str_mv |
Sporotrichosis Cat Fungal burden Itraconazole Potassium iodide |
description |
Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide (KI). Treatment-naïve cats with culture-confirmed sporotrichosis and presenting skin ulcers were treated for up to 40 weeks with oral ITZ alone (n = 74) or combined with KI (n = 56). These cats were submitted to monthly sampling of the same lesion for mycological culture and cytopathology until healing of lesion or up to twelve weeks. The fungal burden was expressed as the mean yeast cell count in three microscopic fields from imprint smears. The fungal burden before treatment was significantly higher in cats in which the lesion persisted and in cases of treatment failure when using ITZ alone. After twelve weeks, the median fungal burden decreased to zero in both treatment protocols, suggesting a potential decrease in the risk of transmission of Sporothrix spp. from cats. These findings encourage the early treatment of feline sporotrichosis as a control measure. Moreover, the fungal burden in feline sporotrichosis lesions can be a prognostic indicator and a parameter for choosing appropriate therapeutic regimen. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-01-12T04:22:52Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/187736 |
dc.identifier.issn.pt_BR.fl_str_mv |
2309-608X |
dc.identifier.nrb.pt_BR.fl_str_mv |
001084096 |
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2309-608X 001084096 |
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http://hdl.handle.net/10183/187736 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of Fungi. Basel. Vol. 4, no. 3 (Sept. 2018), 92, 11 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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