Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration

Detalhes bibliográficos
Autor(a) principal: Savino, Wilson
Data de Publicação: 2007
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33846
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
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spelling Savino, Wilson2019-07-04T16:17:56Z2019-07-04T16:17:56Z2007SAVINO, Wilson. Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration. Experimental Physiology, v. 92, n. 5, p. 813-817, 2007.0958-0670https://www.arca.fiocruz.br/handle/icict/3384610.1113/expphysiol.2007.0384221469-445XengWiley 12 MonthsControle neuroendócrinoCélulas TMamíferosHormônio do crescimentoMigração de timócitosNeuroendocrine controlTcellMammalsGrowth hormoneThymocyte migrationNeuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migrationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.The thymus gland is a primary lymphoid organ, in which bone-marrow-derived T cell precursors undergo differentiation, eventually leading to migration of positively selected cells to the peripheral lymphoid organs. This differentiation occurs along with cell migration in the context of the thymic microenvironment, a three-dimensional network formed by epithelial cells, macrophages, dendritic cells, fibroblasts and extracellular matrix components. A series of data clearly shows that growth hormone (GH) pleiotropically modulates thymic functions. For example, GH upregulates proliferation of thymocytes and thymic epithelial cells. Accordingly, GH-transgenic mice, as well as animals and humans treated with exogenous GH, exhibit an enhanced cellularity in the organ. Growth hormone stimulates the secretion of thymic hormones, cytokines and chemokines by the thymic microenvironment, as well as the production of extracellular matrix proteins, leading to an increase in thymocyte migratory responses and intrathymic traffic of developing T cells. In addition, GH stimulates the in vivo export of thymocytes from the organ, as ascertained by studies with intrathymic injection of GH in normal mice and with GH-transgenic mice. Moreover, since GH is produced by thymocytes and thymic epithelial cells, which express GH receptors, we should consider that, in addition to the classic endocrine pathway, the GH control of the thymus may include an autocrine/paracrine pathway. Finally, since GH promotes a replenishment of the thymus and an increase of thymocyte export, it could be envisioned as a potential adjuvant therapeutic agent in the treatment of immunodeficiencies associated with thymic atrophy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33846/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_IOC_2007.pdfWilsonSavino_IOC_2007.pdfapplication/pdf274453https://www.arca.fiocruz.br/bitstream/icict/33846/2/WilsonSavino_IOC_2007.pdf219532041eecdb1f6016803909ba36fbMD52TEXTWilsonSavino_IOC_2007.pdf.txtWilsonSavino_IOC_2007.pdf.txtExtracted texttext/plain22975https://www.arca.fiocruz.br/bitstream/icict/33846/3/WilsonSavino_IOC_2007.pdf.txtc79b044269f62820bee9b31003048819MD53icict/338462019-07-05 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dc.title.pt_BR.fl_str_mv Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration
title Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration
spellingShingle Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration
Savino, Wilson
Controle neuroendócrino
Células T
Mamíferos
Hormônio do crescimento
Migração de timócitos
Neuroendocrine control
Tcell
Mammals
Growth hormone
Thymocyte migration
title_short Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration
title_full Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration
title_fullStr Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration
title_full_unstemmed Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration
title_sort Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration
author Savino, Wilson
author_facet Savino, Wilson
author_role author
dc.contributor.author.fl_str_mv Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv Controle neuroendócrino
Células T
Mamíferos
Hormônio do crescimento
Migração de timócitos
topic Controle neuroendócrino
Células T
Mamíferos
Hormônio do crescimento
Migração de timócitos
Neuroendocrine control
Tcell
Mammals
Growth hormone
Thymocyte migration
dc.subject.en.pt_BR.fl_str_mv Neuroendocrine control
Tcell
Mammals
Growth hormone
Thymocyte migration
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2019-07-04T16:17:56Z
dc.date.available.fl_str_mv 2019-07-04T16:17:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SAVINO, Wilson. Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration. Experimental Physiology, v. 92, n. 5, p. 813-817, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33846
dc.identifier.issn.pt_BR.fl_str_mv 0958-0670
dc.identifier.doi.pt_BR.fl_str_mv 10.1113/expphysiol.2007.038422
dc.identifier.eissn.none.fl_str_mv 1469-445X
identifier_str_mv SAVINO, Wilson. Neuroendocrine control of Tcell development in mammals: role of growth hormone in modulating thymocyte migration. Experimental Physiology, v. 92, n. 5, p. 813-817, 2007.
0958-0670
10.1113/expphysiol.2007.038422
1469-445X
url https://www.arca.fiocruz.br/handle/icict/33846
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley 12 Months
publisher.none.fl_str_mv Wiley 12 Months
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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