Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/52148 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil. |
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Almeida, Gregório GuilhermeCosta, Pedro Augusto CarvalhoAraujo, Maísa da SilvaGomes, Gabriela RibeiroCarvalho, Alex FioriniFigueiredo, Maria MartaPereira, Dhelio BatistaTada, Mauro ShugiroMedeiros, Jansen FernandesSoares, Irene da SilvaCarvalho, Luzia HelenaKano, Flora SatikoCastro, Marcia Caldas deVinetz, Joseph MichaelGolenbock, Douglas TaylorAntonelli, Lis Ribeiro do ValleGazzinelli, Ricardo Tostes2022-04-11T13:16:42Z2022-04-11T13:16:42Z2021ALMEIDA, Gregório Guilherme et al. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLoS Negl Trop Dis., v. 15, n. 10, e0009077, 2021. doi: 10.1371/journal.pntd.0009077.1935-2735https://www.arca.fiocruz.br/handle/icict/5214810.1371/journal.pntd.0009077engPublic Library of SciencemalariaP. vivaxAsymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil.Fiocruz Rondônia Laboratório de Entomologia. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. Fundação Oswaldo Cruz. Instituto René Rachou. CT vacinas. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. Fundação Oswaldo Cruz. Instituto René Rachou. CT vacinas. Belo Horizonte, MG, Brazil.Centro de Pesquisa em Medicina Tropical. Ambulatório de Malária. Porto Velho, RO, Brazil.Centro de Pesquisa em Medicina Tropical. Ambulatório de Malária. Porto Velho, RO, Brazil.Fiocruz Rondônia Laboratório de Entomologia. Porto Velho, RO, Brazil.Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brazil.Department of Global Health and Population. Harvard T.H. Chan School of Public Health. Boston, MA, United States of America.Section of Infectious Diseases. Department of Internal Medicine. Yale School of Medicine. New Haven, CT, United States of America.Department of Medicine. University of Massachusetts Medical School. Worcester, MA, United States of America.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil/Department of Medicine. University of Massachusetts Medical School. Worcester, MA, United States of America.Individuals with asymptomatic infection due to Plasmodium vivax are posited to be important reservoirs of malaria transmission in endemic regions. Here we studied a cohort of P. vivax malaria patients in a suburban area in the Brazilian Amazon. Overall 1,120 individuals were screened for P. vivax infection and 108 (9.6%) had parasitemia detected by qPCR but not by microscopy. Asymptomatic individuals had higher levels of antibodies against P. vivax and similar hematological and biochemical parameters compared to uninfected controls. Blood from asymptomatic individuals with very low parasitemia transmitted P. vivax to the main local vector, Nyssorhynchus darlingi. Lower mosquito infectivity rates were observed when blood from asymptomatic individuals was used in the membrane feeding assay. While blood from symptomatic patients infected 43.4% (199/458) of the mosquitoes, blood from asymptomatic infected 2.5% (43/1,719). However, several asymptomatic individuals maintained parasitemia for several weeks indicating their potential role as an infectious reservoir. These results suggest that asymptomatic individuals are an important source of malaria parasites and Science and Technology for Vaccines granted by Conselho Nacional de may contribute to the transmission of P. vivax in low-endemicity areas of malariainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/52148/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALAsymptomatic Plasmodium vivax malaria in the.pdfAsymptomatic Plasmodium vivax malaria in the.pdfapplication/pdf7099513https://www.arca.fiocruz.br/bitstream/icict/52148/2/Asymptomatic%20Plasmodium%20vivax%20malaria%20in%20the.pdf0d4dc6cc04420d529ba37f04d6b19c6fMD52icict/521482022-04-11 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Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi |
| title |
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi |
| spellingShingle |
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi Almeida, Gregório Guilherme malaria P. vivax |
| title_short |
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi |
| title_full |
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi |
| title_fullStr |
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi |
| title_full_unstemmed |
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi |
| title_sort |
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi |
| author |
Almeida, Gregório Guilherme |
| author_facet |
Almeida, Gregório Guilherme Costa, Pedro Augusto Carvalho Araujo, Maísa da Silva Gomes, Gabriela Ribeiro Carvalho, Alex Fiorini Figueiredo, Maria Marta Pereira, Dhelio Batista Tada, Mauro Shugiro Medeiros, Jansen Fernandes Soares, Irene da Silva Carvalho, Luzia Helena Kano, Flora Satiko Castro, Marcia Caldas de Vinetz, Joseph Michael Golenbock, Douglas Taylor Antonelli, Lis Ribeiro do Valle Gazzinelli, Ricardo Tostes |
| author_role |
author |
| author2 |
Costa, Pedro Augusto Carvalho Araujo, Maísa da Silva Gomes, Gabriela Ribeiro Carvalho, Alex Fiorini Figueiredo, Maria Marta Pereira, Dhelio Batista Tada, Mauro Shugiro Medeiros, Jansen Fernandes Soares, Irene da Silva Carvalho, Luzia Helena Kano, Flora Satiko Castro, Marcia Caldas de Vinetz, Joseph Michael Golenbock, Douglas Taylor Antonelli, Lis Ribeiro do Valle Gazzinelli, Ricardo Tostes |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Gregório Guilherme Costa, Pedro Augusto Carvalho Araujo, Maísa da Silva Gomes, Gabriela Ribeiro Carvalho, Alex Fiorini Figueiredo, Maria Marta Pereira, Dhelio Batista Tada, Mauro Shugiro Medeiros, Jansen Fernandes Soares, Irene da Silva Carvalho, Luzia Helena Kano, Flora Satiko Castro, Marcia Caldas de Vinetz, Joseph Michael Golenbock, Douglas Taylor Antonelli, Lis Ribeiro do Valle Gazzinelli, Ricardo Tostes |
| dc.subject.other.pt_BR.fl_str_mv |
malaria P. vivax |
| topic |
malaria P. vivax |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil. |
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2021 |
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2021 |
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2022-04-11T13:16:42Z |
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2022-04-11T13:16:42Z |
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ALMEIDA, Gregório Guilherme et al. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLoS Negl Trop Dis., v. 15, n. 10, e0009077, 2021. doi: 10.1371/journal.pntd.0009077. |
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1935-2735 |
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10.1371/journal.pntd.0009077 |
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ALMEIDA, Gregório Guilherme et al. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLoS Negl Trop Dis., v. 15, n. 10, e0009077, 2021. doi: 10.1371/journal.pntd.0009077. 1935-2735 10.1371/journal.pntd.0009077 |
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