Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37130 |
Resumo: | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (grant 154419/2014-1 to MSG)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES) (Finance Code 001 to RPS and SCMAY) for their financial support. |
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Ndidi, Uche SamuelAdanho, Corynne Stephanie AhouefaSantiago, Rayra PereiraYahouédéhou, Sètondji Cocou Modeste AlexandreSantana, Sânzio SilvaMafili, Vitor ValérioPitanga, Thassila NogueiraFonseca, Cleverson AlvesFerreira, Junia Raquel DutraAdorno, Elisângela VitóriaLyra, Isa MenezesAdekile, Adekunle D.Barbosa, Cynara GomesGoncalves, Marilda de Souza2019-11-18T16:54:03Z2019-11-18T16:54:03Z2019NDIDI, Uche Samuel et al. Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia. Disease Markers, p. 1-9, 2019.0278-0240https://www.arca.fiocruz.br/handle/icict/3713010.1155/2019/15804851875-8630Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (grant 154419/2014-1 to MSG)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES) (Finance Code 001 to RPS and SCMAY) for their financial support.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Ahmadu Bello University. Department of Biochemistry. Zaria, Nigeria.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemias. Departamento de Análises Clínicas e Toxicologicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemias. Departamento de Análises Clínicas e Toxicologicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemias. Departamento de Análises Clínicas e Toxicologicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemias. Departamento de Análises Clínicas e Toxicologicas. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemias. Departamento de Análises Clínicas e Toxicologicas. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemias. Departamento de Análises Clínicas e Toxicologicas. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Kuwait University. Faculty of Medicine. Department of Pediatrics. Kuwait.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemias. Departamento de Análises Clínicas e Toxicologicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemias. Departamento de Análises Clínicas e Toxicologicas. Salvador, BA, Brasil.The present study aimed to investigate the association of Nε-carboxymethyllysine (CML) with laboratory parameters and βS haplotypes in pediatric sickle cell anemia (SCA) patients with or without hydroxyurea (HU) therapy. We included 55 children with SCA (SCAtotal), where 27 were on HU treatment (SCA-HU+) and 28 without HU treatment (SCA-HU-). Laboratory characteristics were determined using electronic methods while CML was measured using competitive ELISA. βS haplotypes were determined by RFLP-PCR. Significant increases in MCV and MCH and significant decreases in leukocytes, eosinophils, basophils, atypical lymphocytes, lymphocytes, and monocytes were found in SCA-HU+ compared to SCA-HU-. SCA-HU+ presented significant reduction in aspartate transaminase and lactate dehydrogenase and increase in creatinine levels compared to SCA-HU-. CML levels were significantly higher in both SCA-HU+ and SCA-HU- compared to the healthy control. In addition, a negative correlation was found between CML and alanine transaminase in SCA-HU+ and SCAtotal (p < 0 01). A significant association was found between CML levels and βS haplotypes. The results suggest that CML has a role to play in SCA complications, independent of HU therapy.engHindwaiAnemia falciformeHidroxiureiaTratamentoCriançasSickle cell anemiaHydroxyureaTreatmentChildrenEffect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37130/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNdidi, U. S. Effect....pdfNdidi, U. S. Effect....pdfapplication/pdf5542454https://www.arca.fiocruz.br/bitstream/icict/37130/2/Ndidi%2c%20U.%20S.%20Effect....pdffa2a3b16136b031175a4ffa17f0265f6MD52TEXTNdidi, U. S. Effect....pdf.txtNdidi, U. S. Effect....pdf.txtExtracted texttext/plain38860https://www.arca.fiocruz.br/bitstream/icict/37130/3/Ndidi%2c%20U.%20S.%20Effect....pdf.txte2c3f67b781e47189eb927b6c6281425MD53icict/371302023-03-15 14:32:48.928oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:48Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en.fl_str_mv |
Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia |
| title |
Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia |
| spellingShingle |
Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia Ndidi, Uche Samuel Anemia falciforme Hidroxiureia Tratamento Crianças Sickle cell anemia Hydroxyurea Treatment Children |
| title_short |
Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia |
| title_full |
Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia |
| title_fullStr |
Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia |
| title_full_unstemmed |
Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia |
| title_sort |
Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia |
| author |
Ndidi, Uche Samuel |
| author_facet |
Ndidi, Uche Samuel Adanho, Corynne Stephanie Ahouefa Santiago, Rayra Pereira Yahouédéhou, Sètondji Cocou Modeste Alexandre Santana, Sânzio Silva Mafili, Vitor Valério Pitanga, Thassila Nogueira Fonseca, Cleverson Alves Ferreira, Junia Raquel Dutra Adorno, Elisângela Vitória Lyra, Isa Menezes Adekile, Adekunle D. Barbosa, Cynara Gomes Goncalves, Marilda de Souza |
| author_role |
author |
| author2 |
Adanho, Corynne Stephanie Ahouefa Santiago, Rayra Pereira Yahouédéhou, Sètondji Cocou Modeste Alexandre Santana, Sânzio Silva Mafili, Vitor Valério Pitanga, Thassila Nogueira Fonseca, Cleverson Alves Ferreira, Junia Raquel Dutra Adorno, Elisângela Vitória Lyra, Isa Menezes Adekile, Adekunle D. Barbosa, Cynara Gomes Goncalves, Marilda de Souza |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ndidi, Uche Samuel Adanho, Corynne Stephanie Ahouefa Santiago, Rayra Pereira Yahouédéhou, Sètondji Cocou Modeste Alexandre Santana, Sânzio Silva Mafili, Vitor Valério Pitanga, Thassila Nogueira Fonseca, Cleverson Alves Ferreira, Junia Raquel Dutra Adorno, Elisângela Vitória Lyra, Isa Menezes Adekile, Adekunle D. Barbosa, Cynara Gomes Goncalves, Marilda de Souza |
| dc.subject.other.pt_BR.fl_str_mv |
Anemia falciforme Hidroxiureia Tratamento Crianças |
| topic |
Anemia falciforme Hidroxiureia Tratamento Crianças Sickle cell anemia Hydroxyurea Treatment Children |
| dc.subject.en.en.fl_str_mv |
Sickle cell anemia Hydroxyurea Treatment Children |
| description |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (grant 154419/2014-1 to MSG)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES) (Finance Code 001 to RPS and SCMAY) for their financial support. |
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2019 |
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2019-11-18T16:54:03Z |
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2019-11-18T16:54:03Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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NDIDI, Uche Samuel et al. Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia. Disease Markers, p. 1-9, 2019. |
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https://www.arca.fiocruz.br/handle/icict/37130 |
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0278-0240 |
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10.1155/2019/1580485 |
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1875-8630 |
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NDIDI, Uche Samuel et al. Effect of N(Epsilon)-(carboxymethyl)lysine on laboratory parameters and its association with βS haplotype in children with sickle cell anemia. Disease Markers, p. 1-9, 2019. 0278-0240 10.1155/2019/1580485 1875-8630 |
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