Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5817 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
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Soares, Milena Botelho PereiraLima, Ricardo Santana deRocha, Leonardo LimaVasconcelos, Juliana FragaRogatto, Silvia ReginaSantos, Ricardo Ribeiro dosIacobas, SandaGoldenberg, Regina Coeli dos SantosIacobas, Dumitru AndreiTanowitz, Herbert BernardCarvalho, Antonio Carlos Campos deSpray, David Conover2012-11-14T23:00:42Z2012-11-14T23:00:42Z2010SOARES, M. B. P. et al. Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy. Journal of Infectious Diseases, v. 202, n. 3, p. 416-426, aug. 2010.1527-6613https://www.arca.fiocruz.br/handle/icict/581710.1086/653481engGene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade do Estado de São Paulo. Faculdade de Medicina. Botucatu, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilAlbert Einstein College of Medicine. Bronx, New York, United States of AmericaUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas. Rio de Janeiro, RJ, BrasilAlbert Einstein College of Medicine. Bronx, New York, United States of AmericaAlbert Einstein College of Medicine. Bronx, New York, United States of AmericaUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas. Rio de Janeiro, RJ, BrasilAlbert Einstein College of Medicine. Bronx, New York, United States of AmericaChronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart. We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified significant alterations in expression of approximately 12% of the sampled genes. Extensive up-regulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins, and major histocompatibility complex molecules) and fibrosis (extracellular matrix components, lysyl oxidase, and tissue inhibitor of metalloproteinase 1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide new therapeutic targets in chronic Chagas diseaseChagas'diseaseGene expressionCardiomyopathyInflammationFibrosisCardiomiopatia Chagásica/imunologiaFibrose/imunologiaPerfilação da Expressão GênicaMiocardite/imunologiaTrypanoosoma cruziAnimaisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBotelho.pdfBotelho.pdfapplication/pdf6311208https://www.arca.fiocruz.br/bitstream/icict/5817/1/Botelho.pdfdfa412bb4408d746da33323c76bab66eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5817/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTBotelho.pdf.txtBotelho.pdf.txtExtracted texttext/plain47597https://www.arca.fiocruz.br/bitstream/icict/5817/5/Botelho.pdf.txt963804d9c25a85e5af9dd92219e36db8MD55THUMBNAILBotelho.pdf.jpgBotelho.pdf.jpgGenerated Thumbnailimage/jpeg2234https://www.arca.fiocruz.br/bitstream/icict/5817/4/Botelho.pdf.jpgb3dfc752b29ddb6d27c7773ffa00104eMD54icict/58172023-03-15 14:33:15.704oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy |
| title |
Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy |
| spellingShingle |
Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy Soares, Milena Botelho Pereira Chagas'disease Gene expression Cardiomyopathy Inflammation Fibrosis Cardiomiopatia Chagásica/imunologia Fibrose/imunologia Perfilação da Expressão Gênica Miocardite/imunologia Trypanoosoma cruzi Animais |
| title_short |
Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy |
| title_full |
Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy |
| title_fullStr |
Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy |
| title_full_unstemmed |
Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy |
| title_sort |
Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy |
| author |
Soares, Milena Botelho Pereira |
| author_facet |
Soares, Milena Botelho Pereira Lima, Ricardo Santana de Rocha, Leonardo Lima Vasconcelos, Juliana Fraga Rogatto, Silvia Regina Santos, Ricardo Ribeiro dos Iacobas, Sanda Goldenberg, Regina Coeli dos Santos Iacobas, Dumitru Andrei Tanowitz, Herbert Bernard Carvalho, Antonio Carlos Campos de Spray, David Conover |
| author_role |
author |
| author2 |
Lima, Ricardo Santana de Rocha, Leonardo Lima Vasconcelos, Juliana Fraga Rogatto, Silvia Regina Santos, Ricardo Ribeiro dos Iacobas, Sanda Goldenberg, Regina Coeli dos Santos Iacobas, Dumitru Andrei Tanowitz, Herbert Bernard Carvalho, Antonio Carlos Campos de Spray, David Conover |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Soares, Milena Botelho Pereira Lima, Ricardo Santana de Rocha, Leonardo Lima Vasconcelos, Juliana Fraga Rogatto, Silvia Regina Santos, Ricardo Ribeiro dos Iacobas, Sanda Goldenberg, Regina Coeli dos Santos Iacobas, Dumitru Andrei Tanowitz, Herbert Bernard Carvalho, Antonio Carlos Campos de Spray, David Conover |
| dc.subject.en.pt_BR.fl_str_mv |
Chagas'disease Gene expression Cardiomyopathy Inflammation Fibrosis |
| topic |
Chagas'disease Gene expression Cardiomyopathy Inflammation Fibrosis Cardiomiopatia Chagásica/imunologia Fibrose/imunologia Perfilação da Expressão Gênica Miocardite/imunologia Trypanoosoma cruzi Animais |
| dc.subject.decs.pt_BR.fl_str_mv |
Cardiomiopatia Chagásica/imunologia Fibrose/imunologia Perfilação da Expressão Gênica Miocardite/imunologia Trypanoosoma cruzi Animais |
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Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
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2010 |
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2010 |
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2012-11-14T23:00:42Z |
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2012-11-14T23:00:42Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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| dc.identifier.citation.fl_str_mv |
SOARES, M. B. P. et al. Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy. Journal of Infectious Diseases, v. 202, n. 3, p. 416-426, aug. 2010. |
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https://www.arca.fiocruz.br/handle/icict/5817 |
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1527-6613 |
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10.1086/653481 |
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SOARES, M. B. P. et al. Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy. Journal of Infectious Diseases, v. 202, n. 3, p. 416-426, aug. 2010. 1527-6613 10.1086/653481 |
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