Mechanisms of leukocyte lipid body formation and function in inflammation

Detalhes bibliográficos
Autor(a) principal: Bozza, Patrícia T.
Data de Publicação: 2005
Outros Autores: Melo, Christianne Bandeira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36908
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
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spelling Bozza, Patrícia T.Melo, Christianne Bandeira2019-11-06T16:33:36Z2019-11-06T16:33:36Z2005BOZZA, Patrícia T.; MELO, Christianne Bandeira. Mechanisms of leukocyte lipid body formation and function in inflammation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, suppl. 1, p. 113-120, Mar. 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/3690810.1590/S0074-027620050009000201678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.InflamaçãoCorpos lipídicosEicosanoidesInflammationLipid bodiesEicosanoidsMechanisms of leukocyte lipid body formation and function in inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.An area of increasingly interest for the understanding of cell signaling are the spatio-temporal aspects of the different enzymes involved in lipid mediator generation (eicosanoid-forming enzymes, phospholipases and their regulatory kinases and phosphatases) and pools of lipid precursors. The compartmentalization of signaling components within discrete and dynamic sites in the cell is critical for specificity and efficiency of enzymatic reactions of phosphorilation, enzyme activation and function. We hypothesized that lipid bodies – inducible non-membrane bound cytoplasmic lipid domains – function as specialized intracellular sites of compartmentalization of signaling with major roles in lipid mediator formation within leukocytes engaged in inflammatory process. Over the past years substantial progresses have been made demonstrating that all enzymes involved in eicosanoid synthesis localize at lipid bodies and lipid bodies are distinct sites for eicosanoid generation. Here we will review our current knowledge on the mechanisms of formation and functions of lipid bodies pertinent to inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36908/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaBozza_ChristianeMello_IOC_2005.pdfPatriciaBozza_ChristianeMello_IOC_2005.pdfapplication/pdf66240https://www.arca.fiocruz.br/bitstream/icict/36908/2/PatriciaBozza_ChristianeMello_IOC_2005.pdf035e66822742fcaa6b37b9088ffcd762MD52TEXTPatriciaBozza_ChristianeMello_IOC_2005.pdf.txtPatriciaBozza_ChristianeMello_IOC_2005.pdf.txtExtracted texttext/plain40466https://www.arca.fiocruz.br/bitstream/icict/36908/3/PatriciaBozza_ChristianeMello_IOC_2005.pdf.txt3ddfd44f96b9983f98d16639df57a4e1MD53icict/369082022-06-24 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dc.title.pt_BR.fl_str_mv Mechanisms of leukocyte lipid body formation and function in inflammation
title Mechanisms of leukocyte lipid body formation and function in inflammation
spellingShingle Mechanisms of leukocyte lipid body formation and function in inflammation
Bozza, Patrícia T.
Inflamação
Corpos lipídicos
Eicosanoides
Inflammation
Lipid bodies
Eicosanoids
title_short Mechanisms of leukocyte lipid body formation and function in inflammation
title_full Mechanisms of leukocyte lipid body formation and function in inflammation
title_fullStr Mechanisms of leukocyte lipid body formation and function in inflammation
title_full_unstemmed Mechanisms of leukocyte lipid body formation and function in inflammation
title_sort Mechanisms of leukocyte lipid body formation and function in inflammation
author Bozza, Patrícia T.
author_facet Bozza, Patrícia T.
Melo, Christianne Bandeira
author_role author
author2 Melo, Christianne Bandeira
author2_role author
dc.contributor.author.fl_str_mv Bozza, Patrícia T.
Melo, Christianne Bandeira
dc.subject.other.pt_BR.fl_str_mv Inflamação
Corpos lipídicos
Eicosanoides
topic Inflamação
Corpos lipídicos
Eicosanoides
Inflammation
Lipid bodies
Eicosanoids
dc.subject.en.pt_BR.fl_str_mv Inflammation
Lipid bodies
Eicosanoids
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-11-06T16:33:36Z
dc.date.available.fl_str_mv 2019-11-06T16:33:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOZZA, Patrícia T.; MELO, Christianne Bandeira. Mechanisms of leukocyte lipid body formation and function in inflammation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, suppl. 1, p. 113-120, Mar. 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36908
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762005000900020
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv BOZZA, Patrícia T.; MELO, Christianne Bandeira. Mechanisms of leukocyte lipid body formation and function in inflammation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, suppl. 1, p. 113-120, Mar. 2005.
0074-0276
10.1590/S0074-02762005000900020
1678-8060
url https://www.arca.fiocruz.br/handle/icict/36908
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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