Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism

Detalhes bibliográficos
Autor(a) principal: Bozza, Patrícia T.
Data de Publicação: 1997
Outros Autores: Yu, Wengui, Weller, Peter F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43906
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
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spelling Bozza, Patrícia T.Yu, WenguiWeller, Peter F.2020-10-09T17:35:04Z2020-10-09T17:35:04Z1997BOZZA, Patricia T.; YU, Wengiu; WELLER, Peter F. Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p.135-140, 1997.0074-0276https://www.arca.fiocruz.br/handle/icict/4390610.1590/S0074-027619970008000181678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.EosinophilsCorpos lipídicosEicosanoidesInflamaçãoLipid bodiesEosinophilsEicosanoidsInflammationMechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Harvard Thorndike Laboratory and Charles A. Dana Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School. Boston, MA, USA.Harvard Thorndike Laboratory and Charles A. Dana Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School. Boston, MA, USA.Lipid bodies, inducible lipid-rich cytoplasmic inclusions, are characteristically abundant in cells associated with inflammation, including eosinophils. Here we reviewed the formation and function of lipid bodies in human eosinophils. We now have evidence that the formation of lipid bodies is not attributable to adverse mechanisms, but is centrally mediated by specific signal transduction pathways. Arachidonic acid and other cis fatty acids by an NSAID-inhibitable process, diglycerides, and PAF by a 5-lipoxygenase dependent pathway are potent stimulators of lipid body induction. Lipid body formation develops rapidly by processes that involve PKC, PLC, and de novo mRNA and protein synthesis. These structures clearly serve as repositoires of arachidonyl-phospholipids and are more than inert depots. Specific enzymes, including cytosolic phospholipase A2, MAP kinases, lipoxygenases and cyclooxygenases, associate with lipid bodies. Lipid bodies appear to be dynamic, organelle-like structures involved in intracellular pathways of lipid mobilization and metabolism. Indeed, increases in lipid body numbers correlated with enhanced production of both lipoxygenase- and cyclooxygenase-derived eicosanoids. We hypothesize that lipid bodies are distinct inducible sites for generating eicosanoids as paracrine mediators with varied activities in inflammation. The capacity of lipid body formation to be specifically and rapidly induced in leukocytes enhances eicosanoid mediator formation, and conversely pharmacologic inhibition of lipid body induction represents a potential novel and specific target for anti-inflammatory therapy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43906/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaT_Bozza_etal_IOC_1997.pdfPatriciaT_Bozza_etal_IOC_1997.pdfapplication/pdf79735https://www.arca.fiocruz.br/bitstream/icict/43906/2/PatriciaT_Bozza_etal_IOC_1997.pdf146e28420e875b8efd27bf63aff0f3c3MD52TEXTPatriciaT_Bozza_etal_IOC_1997.pdf.txtPatriciaT_Bozza_etal_IOC_1997.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism
title Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism
spellingShingle Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism
Bozza, Patrícia T.
Eosinophils
Corpos lipídicos
Eicosanoides
Inflamação
Lipid bodies
Eosinophils
Eicosanoids
Inflammation
title_short Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism
title_full Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism
title_fullStr Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism
title_full_unstemmed Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism
title_sort Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism
author Bozza, Patrícia T.
author_facet Bozza, Patrícia T.
Yu, Wengui
Weller, Peter F.
author_role author
author2 Yu, Wengui
Weller, Peter F.
author2_role author
author
dc.contributor.author.fl_str_mv Bozza, Patrícia T.
Yu, Wengui
Weller, Peter F.
dc.subject.other.pt_BR.fl_str_mv Eosinophils
Corpos lipídicos
Eicosanoides
Inflamação
topic Eosinophils
Corpos lipídicos
Eicosanoides
Inflamação
Lipid bodies
Eosinophils
Eicosanoids
Inflammation
dc.subject.en.pt_BR.fl_str_mv Lipid bodies
Eosinophils
Eicosanoids
Inflammation
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2020-10-09T17:35:04Z
dc.date.available.fl_str_mv 2020-10-09T17:35:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOZZA, Patricia T.; YU, Wengiu; WELLER, Peter F. Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p.135-140, 1997.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43906
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761997000800018
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv BOZZA, Patricia T.; YU, Wengiu; WELLER, Peter F. Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p.135-140, 1997.
0074-0276
10.1590/S0074-02761997000800018
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43906
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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