Mechanisms of leukocyte lipid body formation and function in inflammation
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36908 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
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Bozza, Patrícia T.Melo, Christianne Bandeira2019-11-06T16:33:36Z2019-11-06T16:33:36Z2005BOZZA, Patrícia T.; MELO, Christianne Bandeira. Mechanisms of leukocyte lipid body formation and function in inflammation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, suppl. 1, p. 113-120, Mar. 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/3690810.1590/S0074-027620050009000201678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.InflamaçãoCorpos lipídicosEicosanoidesInflammationLipid bodiesEicosanoidsMechanisms of leukocyte lipid body formation and function in inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.An area of increasingly interest for the understanding of cell signaling are the spatio-temporal aspects of the different enzymes involved in lipid mediator generation (eicosanoid-forming enzymes, phospholipases and their regulatory kinases and phosphatases) and pools of lipid precursors. The compartmentalization of signaling components within discrete and dynamic sites in the cell is critical for specificity and efficiency of enzymatic reactions of phosphorilation, enzyme activation and function. We hypothesized that lipid bodies – inducible non-membrane bound cytoplasmic lipid domains – function as specialized intracellular sites of compartmentalization of signaling with major roles in lipid mediator formation within leukocytes engaged in inflammatory process. Over the past years substantial progresses have been made demonstrating that all enzymes involved in eicosanoid synthesis localize at lipid bodies and lipid bodies are distinct sites for eicosanoid generation. Here we will review our current knowledge on the mechanisms of formation and functions of lipid bodies pertinent to inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36908/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaBozza_ChristianeMello_IOC_2005.pdfPatriciaBozza_ChristianeMello_IOC_2005.pdfapplication/pdf66240https://www.arca.fiocruz.br/bitstream/icict/36908/2/PatriciaBozza_ChristianeMello_IOC_2005.pdf035e66822742fcaa6b37b9088ffcd762MD52TEXTPatriciaBozza_ChristianeMello_IOC_2005.pdf.txtPatriciaBozza_ChristianeMello_IOC_2005.pdf.txtExtracted texttext/plain40466https://www.arca.fiocruz.br/bitstream/icict/36908/3/PatriciaBozza_ChristianeMello_IOC_2005.pdf.txt3ddfd44f96b9983f98d16639df57a4e1MD53icict/369082022-06-24 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dc.title.pt_BR.fl_str_mv |
Mechanisms of leukocyte lipid body formation and function in inflammation |
title |
Mechanisms of leukocyte lipid body formation and function in inflammation |
spellingShingle |
Mechanisms of leukocyte lipid body formation and function in inflammation Bozza, Patrícia T. Inflamação Corpos lipídicos Eicosanoides Inflammation Lipid bodies Eicosanoids |
title_short |
Mechanisms of leukocyte lipid body formation and function in inflammation |
title_full |
Mechanisms of leukocyte lipid body formation and function in inflammation |
title_fullStr |
Mechanisms of leukocyte lipid body formation and function in inflammation |
title_full_unstemmed |
Mechanisms of leukocyte lipid body formation and function in inflammation |
title_sort |
Mechanisms of leukocyte lipid body formation and function in inflammation |
author |
Bozza, Patrícia T. |
author_facet |
Bozza, Patrícia T. Melo, Christianne Bandeira |
author_role |
author |
author2 |
Melo, Christianne Bandeira |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Bozza, Patrícia T. Melo, Christianne Bandeira |
dc.subject.other.pt_BR.fl_str_mv |
Inflamação Corpos lipídicos Eicosanoides |
topic |
Inflamação Corpos lipídicos Eicosanoides Inflammation Lipid bodies Eicosanoids |
dc.subject.en.pt_BR.fl_str_mv |
Inflammation Lipid bodies Eicosanoids |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005 |
dc.date.accessioned.fl_str_mv |
2019-11-06T16:33:36Z |
dc.date.available.fl_str_mv |
2019-11-06T16:33:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BOZZA, Patrícia T.; MELO, Christianne Bandeira. Mechanisms of leukocyte lipid body formation and function in inflammation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, suppl. 1, p. 113-120, Mar. 2005. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36908 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762005000900020 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
BOZZA, Patrícia T.; MELO, Christianne Bandeira. Mechanisms of leukocyte lipid body formation and function in inflammation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, suppl. 1, p. 113-120, Mar. 2005. 0074-0276 10.1590/S0074-02762005000900020 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/36908 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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