Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infection

Detalhes bibliográficos
Autor(a) principal: Peters, Nathan C.
Data de Publicação: 2014
Outros Autores: Pagán, Antonio J., Lawyer, Phillip G., Hand, Timothy W., Roma, Eric Henrique, Stamper, Lisa W., Romano, Audrey, Sacks, David L. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35604
Resumo: Eric Henrique Roma. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Peters, Nathan C.Pagán, Antonio J.Lawyer, Phillip G.Hand, Timothy W.Roma, Eric HenriqueStamper, Lisa W.Romano, AudreySacks, David L. S.2019-09-16T13:57:21Z2019-09-16T13:57:21Z2014PETERS, Nathan C. Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection. Plos Pathogens, v. 10, n. 12, p. 1-17, Dec. 2014.1553-7366https://www.arca.fiocruz.br/handle/icict/3560410.1371/journal.ppat.10045381553-7374Eric Henrique Roma. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA.University of Minnesota. Medical School. Center for Immunology. Department of Microbiology. Minneapolis, MN. USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA.In contrast to the ability of long-lived CD8+ memory T cells to mediate protection against systemic viral infections, the relationship between CD4+ T cell memory and acquired resistance against infectious pathogens remains poorly defined. This is especially true for T helper 1 (Th1) concomitant immunity, in which protection against reinfection coincides with a persisting primary infection. In these situations, pre-existing effector CD4 T cells generated by ongoing chronic infection, not memory cells, may be essential for protection against reinfection. We present a systematic study of the tissue homing properties, functionality, and life span of subsets of memory and effector CD4 T cells activated in the setting of chronic Leishmania major infection in resistant C57Bl/6 mice. We found that pre-existing, CD44+CD62L2T-bet+Ly6C+ effector (TEFF) cells that are short-lived in the absence of infection and are not derived from memory cells reactivated by secondary challenge, mediate concomitant immunity. Upon adoptive transfer and challenge, non-dividing Ly6C+ TEFF cells preferentially homed to the skin, released IFN-c, and conferred protection as compared to CD44+ CD62L2Ly6C2 effector memory or CD44+CD62L+Ly6C2 central memory cells. During chronic infection, Ly6C+ TEFF cells were maintained at high frequencies via reactivation of TCM and the TEFF themselves. The lack of effective vaccines for many chronic diseases may be because protection against infectious challenge requires the maintenance of pre-existing TEFF cells, and is therefore not amenable to conventional, memory inducing, vaccination strategies.eng1553-7374Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChronic infectious diseasesEffector T cellsRe-infectioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35604/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Peters_Nathan_etal_INI_2014.pdfve_Peters_Nathan_etal_INI_2014.pdfapplication/pdf2572132https://www.arca.fiocruz.br/bitstream/icict/35604/2/ve_Peters_Nathan_etal_INI_2014.pdf4e65c8227516134dc5055a1db2169065MD52TEXTve_Peters_Nathan_etal_INI_2014.pdf.txtve_Peters_Nathan_etal_INI_2014.pdf.txtExtracted texttext/plain78665https://www.arca.fiocruz.br/bitstream/icict/35604/3/ve_Peters_Nathan_etal_INI_2014.pdf.txtc1194cef020817895ec9f56178fe9eb0MD53icict/356042019-09-17 02:02:16.735oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-09-17T05:02:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infection
title Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infection
spellingShingle Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infection
Peters, Nathan C.
Chronic infectious diseases
Effector T cells
Re-infection
title_short Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infection
title_full Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infection
title_fullStr Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infection
title_full_unstemmed Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infection
title_sort Chronic parasitic infection maintains high frequencies of short-lived ly6c+CD4+ effector T cells that are required for protection against re-infection
author Peters, Nathan C.
author_facet Peters, Nathan C.
Pagán, Antonio J.
Lawyer, Phillip G.
Hand, Timothy W.
Roma, Eric Henrique
Stamper, Lisa W.
Romano, Audrey
Sacks, David L. S.
author_role author
author2 Pagán, Antonio J.
Lawyer, Phillip G.
Hand, Timothy W.
Roma, Eric Henrique
Stamper, Lisa W.
Romano, Audrey
Sacks, David L. S.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Peters, Nathan C.
Pagán, Antonio J.
Lawyer, Phillip G.
Hand, Timothy W.
Roma, Eric Henrique
Stamper, Lisa W.
Romano, Audrey
Sacks, David L. S.
dc.subject.en.pt_BR.fl_str_mv Chronic infectious diseases
Effector T cells
Re-infection
topic Chronic infectious diseases
Effector T cells
Re-infection
description Eric Henrique Roma. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2019-09-16T13:57:21Z
dc.date.available.fl_str_mv 2019-09-16T13:57:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv PETERS, Nathan C. Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection. Plos Pathogens, v. 10, n. 12, p. 1-17, Dec. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35604
dc.identifier.issn.pt_BR.fl_str_mv 1553-7366
dc.identifier.doi.none.fl_str_mv 10.1371/journal.ppat.1004538
dc.identifier.eissn.none.fl_str_mv 1553-7374
identifier_str_mv PETERS, Nathan C. Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection. Plos Pathogens, v. 10, n. 12, p. 1-17, Dec. 2014.
1553-7366
10.1371/journal.ppat.1004538
1553-7374
url https://www.arca.fiocruz.br/handle/icict/35604
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