Activity of the artemether in experimental schistosomiasis mansoni

Detalhes bibliográficos
Autor(a) principal: Araújo, Neusa
Data de Publicação: 1991
Outros Autores: Kohn, Anna, Katz, Naftale
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43469
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
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spelling Araújo, NeusaKohn, AnnaKatz, Naftale2020-09-18T20:27:50Z2020-09-18T20:27:50Z1991ARAÚJO, Neusa; KOHN, Anna; KATZ, Naftale. Activity of the artemether in experimental schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 86, Suppl.2, p. 185-188, 1991.0074-0276https://www.arca.fiocruz.br/handle/icict/4346910.1590/S0074-027619910006000421678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Schistosoma mansoniArtemeterTerapêutica experimentalEsquistossomicidaSchistosoma mansoniArtemetherExperimental therapeuticSchistosomicideActivity of the artemether in experimental schistosomiasis mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilThe action of the ether artemisinin (artemether) on Schistosoma mansoni in mice and the hansters experimentally infected with the LE strain was studied. In mice, the drugs showed high schistosomicidal activity using a single intramuscular dose of 100 mg/Kg/day. By the oral route, this dose showed a low activity. Mice treated with a single intramuscular dose of 200 mg/Kg/day, and examined 15 days after treatment, presented 100% alteration of the oogram; when examined 45 days after treatment, the oogram was normal. With doses of 100 mg/Kg/day, i.m., during 3 or 5 consecutive days, the death rate of mice was very high. Morphologic analysis of the worms collected by perfusion of mice treated with a single dose of 100 mg/Kg/day, i.m., detected a marked decrease in the length of male and female forms, degenerative alterations in the parenchyma and in the reproductive system of the females, with reduction of vitellinic material and in ovary volume; the intestinal contents presented a marked despigmentation. 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dc.title.pt_BR.fl_str_mv Activity of the artemether in experimental schistosomiasis mansoni
title Activity of the artemether in experimental schistosomiasis mansoni
spellingShingle Activity of the artemether in experimental schistosomiasis mansoni
Araújo, Neusa
Schistosoma mansoni
Artemeter
Terapêutica experimental
Esquistossomicida
Schistosoma mansoni
Artemether
Experimental therapeutic
Schistosomicide
title_short Activity of the artemether in experimental schistosomiasis mansoni
title_full Activity of the artemether in experimental schistosomiasis mansoni
title_fullStr Activity of the artemether in experimental schistosomiasis mansoni
title_full_unstemmed Activity of the artemether in experimental schistosomiasis mansoni
title_sort Activity of the artemether in experimental schistosomiasis mansoni
author Araújo, Neusa
author_facet Araújo, Neusa
Kohn, Anna
Katz, Naftale
author_role author
author2 Kohn, Anna
Katz, Naftale
author2_role author
author
dc.contributor.author.fl_str_mv Araújo, Neusa
Kohn, Anna
Katz, Naftale
dc.subject.other.pt_BR.fl_str_mv Schistosoma mansoni
Artemeter
Terapêutica experimental
Esquistossomicida
topic Schistosoma mansoni
Artemeter
Terapêutica experimental
Esquistossomicida
Schistosoma mansoni
Artemether
Experimental therapeutic
Schistosomicide
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Artemether
Experimental therapeutic
Schistosomicide
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
publishDate 1991
dc.date.issued.fl_str_mv 1991
dc.date.accessioned.fl_str_mv 2020-09-18T20:27:50Z
dc.date.available.fl_str_mv 2020-09-18T20:27:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAÚJO, Neusa; KOHN, Anna; KATZ, Naftale. Activity of the artemether in experimental schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 86, Suppl.2, p. 185-188, 1991.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43469
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761991000600042
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv ARAÚJO, Neusa; KOHN, Anna; KATZ, Naftale. Activity of the artemether in experimental schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 86, Suppl.2, p. 185-188, 1991.
0074-0276
10.1590/S0074-02761991000600042
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43469
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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