Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35357 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil. |
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Di Blasi, TatianaTelleria, Erich LozaMarques, ChristianeCouto, Rodrigo de MacedoNeves, Monique da SilvaJancarova, MagdalenaVolf, PetrTempone, Antonio JorgeTraub-Csekö, Yara Maria2019-09-05T15:38:42Z2019-09-05T15:38:42Z2019DI BIASI, Tatiana et al. Lutzomyia longipalpis TGF-b Has a Role in Leishmania infantum chagasi Survival in the Vector. Frontiers in Cellular and Infection Microbiology, v. 9, p. 1-11, Mar. 2019.2235-2988https://www.arca.fiocruz.br/handle/icict/3535710.3389/fcimb.2019.00071engFrontiers MediaLutzomyia longipalpisLeishmaniaInteração vetor-parasitaLutzomyia longipalpisLeishmaniaVector-parasite interactionInnate immunityTGF-bActivinFator de Crescimento Transformador betaImunidade InataAtivinasLutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vectorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil / Charles University. Faculty of Science. Parasitology Department. Prague, Czechia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Charles University. Faculty of Science. Parasitology Department. Prague, Czechia.Charles University. Faculty of Science. Parasitology Department. Prague, Czechia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Despite the increasing number of studies concerning insect immunity, Lutzomyia longipalpis immune responses in the presence of Leishmania infantum chagasi infection has not been widely investigated. The few available studies analyzed the role of the Toll and IMD pathways involved in response against Leishmania and microbial infections. Nevertheless, effector molecules responsible for controlling sand fly infections have not been identified. In the present study we investigated the role a signal transduction pathway, the Transforming Growth Factor-beta (TGF-β) pathway, on the interrelation between L. longipalpis and L. i. chagasi. We identified an L. longipalpis homolog belonging to the multifunctional cytokine TGF-β gene family (LlTGF-β), which is closely related to the activin/inhibin subfamily and potentially involved in responses to infections. We investigated this gene expression through the insect development and in adult flies infected with L. i. chagasi. Our results showed that LlTGF-β was expressed in all L. longipalpis developmental stages and was upregulated at the third day post L. i. chagasi infection, when protein levels were also higher as compared to uninfected insects. At this point blood digestion is finished and parasites are in close contact with the insect gut. In addition, we investigated the role of LlTGF-β on L. longipalpis infection by L. i. chagasi using either gene silencing by RNAi or pathway inactivation by addition of the TGF-β receptor inhibitor SB431542. The blockage of the LlTGF-β pathway increased significantly antimicrobial peptides expression and nitric oxide levels in the insect gut, as expected. Both methods led to a decreased L. i. chagasi infection. Our results show that inactivation of the L. longipalpis TGF-β signal transduction pathway reduce L. i. chagasi survival, therefore suggesting that under natural conditions the parasite benefits from the insect LlTGF-β pathway, as already seen in Plamodium infection of mosquitoes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35357/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRodrigoCouto_MoniqueNeves_etal_IOC_2109.pdfRodrigoCouto_MoniqueNeves_etal_IOC_2109.pdfapplication/pdf2618362https://www.arca.fiocruz.br/bitstream/icict/35357/2/RodrigoCouto_MoniqueNeves_etal_IOC_2109.pdfbe91dfa85ae395bc11742c7dc2151d9aMD52TEXTRodrigoCouto_MoniqueNeves_etal_IOC_2109.pdf.txtRodrigoCouto_MoniqueNeves_etal_IOC_2109.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector |
title |
Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector |
spellingShingle |
Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector Di Blasi, Tatiana Lutzomyia longipalpis Leishmania Interação vetor-parasita Lutzomyia longipalpis Leishmania Vector-parasite interaction Innate immunity TGF-b Activin Fator de Crescimento Transformador beta Imunidade Inata Ativinas |
title_short |
Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector |
title_full |
Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector |
title_fullStr |
Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector |
title_full_unstemmed |
Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector |
title_sort |
Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector |
author |
Di Blasi, Tatiana |
author_facet |
Di Blasi, Tatiana Telleria, Erich Loza Marques, Christiane Couto, Rodrigo de Macedo Neves, Monique da Silva Jancarova, Magdalena Volf, Petr Tempone, Antonio Jorge Traub-Csekö, Yara Maria |
author_role |
author |
author2 |
Telleria, Erich Loza Marques, Christiane Couto, Rodrigo de Macedo Neves, Monique da Silva Jancarova, Magdalena Volf, Petr Tempone, Antonio Jorge Traub-Csekö, Yara Maria |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Di Blasi, Tatiana Telleria, Erich Loza Marques, Christiane Couto, Rodrigo de Macedo Neves, Monique da Silva Jancarova, Magdalena Volf, Petr Tempone, Antonio Jorge Traub-Csekö, Yara Maria |
dc.subject.other.pt_BR.fl_str_mv |
Lutzomyia longipalpis Leishmania Interação vetor-parasita |
topic |
Lutzomyia longipalpis Leishmania Interação vetor-parasita Lutzomyia longipalpis Leishmania Vector-parasite interaction Innate immunity TGF-b Activin Fator de Crescimento Transformador beta Imunidade Inata Ativinas |
dc.subject.en.pt_BR.fl_str_mv |
Lutzomyia longipalpis Leishmania Vector-parasite interaction Innate immunity TGF-b Activin |
dc.subject.decs.pt_BR.fl_str_mv |
Fator de Crescimento Transformador beta Imunidade Inata Ativinas |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-09-05T15:38:42Z |
dc.date.available.fl_str_mv |
2019-09-05T15:38:42Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
DI BIASI, Tatiana et al. Lutzomyia longipalpis TGF-b Has a Role in Leishmania infantum chagasi Survival in the Vector. Frontiers in Cellular and Infection Microbiology, v. 9, p. 1-11, Mar. 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/35357 |
dc.identifier.issn.pt_BR.fl_str_mv |
2235-2988 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fcimb.2019.00071 |
identifier_str_mv |
DI BIASI, Tatiana et al. Lutzomyia longipalpis TGF-b Has a Role in Leishmania infantum chagasi Survival in the Vector. Frontiers in Cellular and Infection Microbiology, v. 9, p. 1-11, Mar. 2019. 2235-2988 10.3389/fcimb.2019.00071 |
url |
https://www.arca.fiocruz.br/handle/icict/35357 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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Frontiers Media |
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Frontiers Media |
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