Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48148 |
Resumo: | Wellcome Trust, Grant/Award Number: 088862/Z/09/Z |
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Cooper, Philip J.Ster, Irina ChisChico, Martha E.Vaca, MaritzaOviedo, YiselaMaldonado, AugustoBarreto, Maurício LimaMills, Thomas A. E. PlattsStrachan, David P.2021-07-12T14:18:29Z2021-07-12T14:18:29Z2021COOPER, Philip J. et al. Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years. Allergy, p. 1-11, 20 Mar. 2021.0105-4538https://www.arca.fiocruz.br/handle/icict/4814810.1111/all.148211398-9995Wellcome Trust, Grant/Award Number: 088862/Z/09/ZSt George's University of London. Institute of Infection and Immunity. London, UK / Universidad Internacional del Ecuador. School of Medicine. Quito, Ecuador / Fundacion Ecuatoriana Para La Investigacion en Salud. Quito, Ecuador.St George's University of London. Institute of Infection and Immunity. London, United Kingdom.Fundacion Ecuatoriana Para La Investigacion en Salud. Quito, Ecuador.Fundacion Ecuatoriana Para La Investigacion en Salud. Quito, Ecuador.Fundacion Ecuatoriana Para La Investigacion en Salud. Quito, Ecuador.Fundacion Ecuatoriana Para La Investigacion en Salud. Quito, Ecuador / Universidad San Francisco de Quito. Colegio de Ciencias de la Salud. Quito, Ecuador.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.University of Virginia. Division of Allergy and Clinical Immunology. Charlottesville, VA, USA.St George's University of London. Population Health Research Institute. London, United Kingdom.Background: Early-life exposures to geohelminths may protect against development of wheeze/asthma and atopy. Objective: To study the effect of maternal geohelminths and infections in children during the first 5 years on atopy, wheeze/asthma and airways reactivity/inflammation at 8 years. Methods: Birth cohort of 2404 neonates followed to 8 years in rural Ecuador. Data on wheeze/asthma were collected by questionnaire and atopy by skin prick test (SPT) reactivity to 9 allergens. We measured airways reactivity to bronchodilator, fractional exhaled nitric oxide (FeNO) and nasal eosinophilia. Stool samples were examined for geohelminths by microscopy. Results: 1933 (80.4%) children were evaluated at 8 years. Geohelminths were detected in 45.8% of mothers and 45.5% of children to 5 years. Frequencies of outcomes at 8 years were as follows: wheeze (6.6%), asthma between 5 and 8 years (7.9%), SPT (14.7%), airways reactivity (10%) and elevated FeNO (10.3%) and nasal eosinophilia (9.2%). Any maternal geohelminth was associated with reduced SPT prevalence (OR 0.72). Childhood Trichuris trichiura infections during the first 5 years were associated with reduced wheeze (OR 0.57) but greater parasite burdens with Ascaris lumbricoides at 5 years were associated with increased wheeze (OR 2.83) and asthma (OR 2.60). Associations between maternal geohelminths and wheeze/asthma were modified by atopy. Parasite-specific effects on wheeze/asthma and airways reactivity and inflammation were observed in non-atopic children. Conclusions: Our data provide novel evidence for persistent effects of in utero geohelminth exposures on childhood atopy but highlight the complex nature of the relationship between geohelminths and the airways. Registered as an observational study (ISRCTN41239086).engJohn Wiley and SonsAsmaInfecçõesEquadorÓxido nítricoCriançaBroncodilatadoresAsthmaAtopyEcuadorGeohelminthsWheezeImpact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 yearsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48148/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCooper, J. P. Impact of early....pdfCooper, J. P. Impact of early....pdfapplication/pdf1218802https://www.arca.fiocruz.br/bitstream/icict/48148/2/Cooper%2c%20J.%20P.%20Impact%20of%20early....pdfa56248c360e93d0f668bad7390a52601MD52TEXTCooper, J. P. Impact of early....pdf.txtCooper, J. P. Impact of early....pdf.txtExtracted texttext/plain47336https://www.arca.fiocruz.br/bitstream/icict/48148/3/Cooper%2c%20J.%20P.%20Impact%20of%20early....pdf.txt02c27658f66936ac359d0e914d42edfdMD53icict/481482023-03-15 14:34:21.349oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en.fl_str_mv |
Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years |
| title |
Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years |
| spellingShingle |
Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years Cooper, Philip J. Asma Infecções Equador Óxido nítrico Criança Broncodilatadores Asthma Atopy Ecuador Geohelminths Wheeze |
| title_short |
Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years |
| title_full |
Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years |
| title_fullStr |
Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years |
| title_full_unstemmed |
Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years |
| title_sort |
Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years |
| author |
Cooper, Philip J. |
| author_facet |
Cooper, Philip J. Ster, Irina Chis Chico, Martha E. Vaca, Maritza Oviedo, Yisela Maldonado, Augusto Barreto, Maurício Lima Mills, Thomas A. E. Platts Strachan, David P. |
| author_role |
author |
| author2 |
Ster, Irina Chis Chico, Martha E. Vaca, Maritza Oviedo, Yisela Maldonado, Augusto Barreto, Maurício Lima Mills, Thomas A. E. Platts Strachan, David P. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cooper, Philip J. Ster, Irina Chis Chico, Martha E. Vaca, Maritza Oviedo, Yisela Maldonado, Augusto Barreto, Maurício Lima Mills, Thomas A. E. Platts Strachan, David P. |
| dc.subject.other.pt_BR.fl_str_mv |
Asma Infecções Equador Óxido nítrico Criança Broncodilatadores |
| topic |
Asma Infecções Equador Óxido nítrico Criança Broncodilatadores Asthma Atopy Ecuador Geohelminths Wheeze |
| dc.subject.en.en.fl_str_mv |
Asthma Atopy Ecuador Geohelminths Wheeze |
| description |
Wellcome Trust, Grant/Award Number: 088862/Z/09/Z |
| publishDate |
2021 |
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2021-07-12T14:18:29Z |
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2021-07-12T14:18:29Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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COOPER, Philip J. et al. Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years. Allergy, p. 1-11, 20 Mar. 2021. |
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https://www.arca.fiocruz.br/handle/icict/48148 |
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0105-4538 |
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10.1111/all.14821 |
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1398-9995 |
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COOPER, Philip J. et al. Impact of early life geohelminths on wheeze, asthma and atopy in ecuadorian children at 8 years. Allergy, p. 1-11, 20 Mar. 2021. 0105-4538 10.1111/all.14821 1398-9995 |
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John Wiley and Sons |
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John Wiley and Sons |
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