Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report

Detalhes bibliográficos
Autor(a) principal: Silva, Kátia Nunes da
Data de Publicação: 2021
Outros Autores: Pinheiro, Priscila Carvalho Guedes, Gobatto, André Luiz Nunes, Passos, Rogério da Hora, Paredes, Bruno Diaz, França, Luciana Souza de Aragão, Nonaka, Carolina Kymie Vasques, Duarte, Beatriz Barreto, Pereira, Mariana Araújo, Tibúrcio, Rafael, Cruz, Fernanda Ferreira, Martins, Gabriele Louise Soares, Andrade, Bruno Bezerril de, Faria Neto, Hugo Caire de Castro, Rocco, Patricia Rieken Macêdo, Souza, Bruno Solano de Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50210
Resumo: 1 Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Brazil, 2 D’Or Institute for Research and Education (IDOR), Salvador, Brazil, 3 Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Brazil, 4 Critical Care Unit, São Rafael Hospital, Salvador, Brazil, 5 Curso de Medicina, Universidade Salvador (UNIFACS), Laureate International Universities, Salvador, Brazil, 6 Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 7Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil, 8 Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil, 9 Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, 10 COVID-19 Virus Network from Brazilian Council for Scientific and Technological Development, Brasília, Brazil, 11 COVID-19 Virus Network from Foundation Carlos Chagas Filho Research Support of the State of Rio de Janeiro, Rio de Janeiro, Brazil, 12 National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil, 13 Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
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spelling Silva, Kátia Nunes daPinheiro, Priscila Carvalho GuedesGobatto, André Luiz NunesPassos, Rogério da HoraParedes, Bruno DiazFrança, Luciana Souza de AragãoNonaka, Carolina Kymie VasquesDuarte, Beatriz BarretoPereira, Mariana AraújoTibúrcio, RafaelCruz, Fernanda FerreiraMartins, Gabriele Louise SoaresAndrade, Bruno Bezerril deFaria Neto, Hugo Caire de CastroRocco, Patricia Rieken MacêdoSouza, Bruno Solano de Freitas2021-12-07T19:58:38Z2021-12-07T19:58:38Z2021SILVA, Kátia Nunes da et al. Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report. Frontiers Media, 2021.2296-858Xhttps://www.arca.fiocruz.br/handle/icict/5021010.3389/fmed.2021.7672911 Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Brazil, 2 D’Or Institute for Research and Education (IDOR), Salvador, Brazil, 3 Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Brazil, 4 Critical Care Unit, São Rafael Hospital, Salvador, Brazil, 5 Curso de Medicina, Universidade Salvador (UNIFACS), Laureate International Universities, Salvador, Brazil, 6 Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 7Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil, 8 Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil, 9 Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, 10 COVID-19 Virus Network from Brazilian Council for Scientific and Technological Development, Brasília, Brazil, 11 COVID-19 Virus Network from Foundation Carlos Chagas Filho Research Support of the State of Rio de Janeiro, Rio de Janeiro, Brazil, 12 National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil, 13 Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, BrazilSerrapilheira Foundation, D’Or Institute for Research and Education (IDOR), CNPq, and CAPES."Múltipla ver em Notas"Background: The patients with coronavirus disease 2019 (COVID-19) associated with severe acute respiratory distress syndrome (ARDS) may require prolonged mechanical ventilation which often results in lung fibrosis, thus worsening the prognosis and increasing fatality rates. A mesenchymal stromal cell (MSC) therapy may decrease lung inflammation and accelerate recovery in COVID-19. In this context, some studies have reported the effects ofMSC therapy for patients not requiring invasive ventilation or during the first hours of tracheal intubation. However, this is the first case report presenting the reduction of not only lung inflammation but also lung fibrosis in a critically ill long-term mechanically ventilated patient with COVID-19. Case Presentation: This is a case report of a 30-year-old male patient with COVID-19 under invasive mechanical ventilation for 14 days in the intensive care unit (ICU), who presented progressive clinical deterioration associated with lung fibrosis. The symptoms onset was 35 days before MSC therapy. The patient was treated with allogenic human umbilical-cord derived MSCs [5 × 107 (2 doses 2 days interval)]. No serious adverse events were observed during and after MSC administration. After MSC therapy, PaO2/FiO2 ratio increased, the need for vasoactive drugs reduced, chest CT scan imaging, which initially showed signs of bilateral and peripheral ground-glass, as well as consolidation and fibrosis, improved, and the systemic mediators associated with inflammation decreased. Modulation of the different cell populations in peripheral blood was also observed, such as a reduction in inflammatory monocytes and an increase in the frequency of patrolling monocytes, CD4+ lymphocytes, and type 2 classical dendritic cells (cDC2). The patient was discharged 13 days after the cell therapy. Conclusions: Mesenchymal stromal cell therapy may be a promising option in critically ill patients with COVID-19 presenting both severe lung inflammation and fibrosis. Further clinical trials could better assess the efficacy of MSC therapy in critically ill patients with COVID-19 with lung fibrosis associated with long-term mechanical ventilation.engFrontiers MediaCOVID-19Síndrome do Desconforto RespiratórioCélulas estromais mesenquimaisTerapia celularImunomodulaçãoFibroseCOVID-19ARDSMesenchymal stromal cellsCell therapyImmunomodulationFibrosisImmunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50210/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSilva, Katia Nunes Immunomodulatory....pdfSilva, 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dc.title.pt_BR.fl_str_mv Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
title Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
spellingShingle Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
Silva, Kátia Nunes da
COVID-19
Síndrome do Desconforto Respiratório
Células estromais mesenquimais
Terapia celular
Imunomodulação
Fibrose
COVID-19
ARDS
Mesenchymal stromal cells
Cell therapy
Immunomodulation
Fibrosis
title_short Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
title_full Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
title_fullStr Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
title_full_unstemmed Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
title_sort Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
author Silva, Kátia Nunes da
author_facet Silva, Kátia Nunes da
Pinheiro, Priscila Carvalho Guedes
Gobatto, André Luiz Nunes
Passos, Rogério da Hora
Paredes, Bruno Diaz
França, Luciana Souza de Aragão
Nonaka, Carolina Kymie Vasques
Duarte, Beatriz Barreto
Pereira, Mariana Araújo
Tibúrcio, Rafael
Cruz, Fernanda Ferreira
Martins, Gabriele Louise Soares
Andrade, Bruno Bezerril de
Faria Neto, Hugo Caire de Castro
Rocco, Patricia Rieken Macêdo
Souza, Bruno Solano de Freitas
author_role author
author2 Pinheiro, Priscila Carvalho Guedes
Gobatto, André Luiz Nunes
Passos, Rogério da Hora
Paredes, Bruno Diaz
França, Luciana Souza de Aragão
Nonaka, Carolina Kymie Vasques
Duarte, Beatriz Barreto
Pereira, Mariana Araújo
Tibúrcio, Rafael
Cruz, Fernanda Ferreira
Martins, Gabriele Louise Soares
Andrade, Bruno Bezerril de
Faria Neto, Hugo Caire de Castro
Rocco, Patricia Rieken Macêdo
Souza, Bruno Solano de Freitas
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Kátia Nunes da
Pinheiro, Priscila Carvalho Guedes
Gobatto, André Luiz Nunes
Passos, Rogério da Hora
Paredes, Bruno Diaz
França, Luciana Souza de Aragão
Nonaka, Carolina Kymie Vasques
Duarte, Beatriz Barreto
Pereira, Mariana Araújo
Tibúrcio, Rafael
Cruz, Fernanda Ferreira
Martins, Gabriele Louise Soares
Andrade, Bruno Bezerril de
Faria Neto, Hugo Caire de Castro
Rocco, Patricia Rieken Macêdo
Souza, Bruno Solano de Freitas
dc.subject.other.pt_BR.fl_str_mv COVID-19
Síndrome do Desconforto Respiratório
Células estromais mesenquimais
Terapia celular
Imunomodulação
Fibrose
topic COVID-19
Síndrome do Desconforto Respiratório
Células estromais mesenquimais
Terapia celular
Imunomodulação
Fibrose
COVID-19
ARDS
Mesenchymal stromal cells
Cell therapy
Immunomodulation
Fibrosis
dc.subject.en.pt_BR.fl_str_mv COVID-19
ARDS
Mesenchymal stromal cells
Cell therapy
Immunomodulation
Fibrosis
description 1 Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Brazil, 2 D’Or Institute for Research and Education (IDOR), Salvador, Brazil, 3 Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Brazil, 4 Critical Care Unit, São Rafael Hospital, Salvador, Brazil, 5 Curso de Medicina, Universidade Salvador (UNIFACS), Laureate International Universities, Salvador, Brazil, 6 Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 7Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil, 8 Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil, 9 Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, 10 COVID-19 Virus Network from Brazilian Council for Scientific and Technological Development, Brasília, Brazil, 11 COVID-19 Virus Network from Foundation Carlos Chagas Filho Research Support of the State of Rio de Janeiro, Rio de Janeiro, Brazil, 12 National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil, 13 Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-07T19:58:38Z
dc.date.available.fl_str_mv 2021-12-07T19:58:38Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Kátia Nunes da et al. Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report. Frontiers Media, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50210
dc.identifier.issn.pt_BR.fl_str_mv 2296-858X
dc.identifier.doi.none.fl_str_mv 10.3389/fmed.2021.767291
identifier_str_mv SILVA, Kátia Nunes da et al. Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report. Frontiers Media, 2021.
2296-858X
10.3389/fmed.2021.767291
url https://www.arca.fiocruz.br/handle/icict/50210
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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