Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study

Detalhes bibliográficos
Autor(a) principal: Leonhard SE
Data de Publicação: 2021
Outros Autores: Halstead S, Lant SB, Militão de Albuquerque MFP, de Brito CAA, de Albuquerque LBB, Ellul MA, de Oliveira França RF, Gourlay D, Griffiths MJ, de Miranda Henriques-Souza AM, de Morais Machado MÍ, Medialdea-Carrera R, Mehta R, da Paz Melo R, Mesquita SD, Moreira ÁJP, Pena LJ, Santos ML, Turtle L, Solomon T, Willison HJ, Jacobs BC, Brito Ferreira ML.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57693
Resumo: University of Glasgow, Department of Neurology and Institute of Infection, Immunity and Inflammation, Glasgow, UK. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Saúde Coletiva, Recife, Pernambuco, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Clinica , Recife, Brazil. Instituto de Medicina Integral Professor Fernando Figueira (IMIP) Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Virologia, Recife, Brasil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Hospital da Restauração, Departamento de Pediatria Neurologica, Recife, Brasil. Hospital da Restauração, Departamento de Neurologia Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK. Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
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spelling Leonhard SEHalstead SLant SBMilitão de Albuquerque MFPde Brito CAAde Albuquerque LBBEllul MAde Oliveira França RFGourlay DGriffiths MJde Miranda Henriques-Souza AMde Morais Machado MÍMedialdea-Carrera RMehta Rda Paz Melo RMesquita SDMoreira ÁJPPena LJSantos MLTurtle LSolomon TWillison HJJacobs BCBrito Ferreira ML.2023-04-05T14:41:50Z2023-04-05T14:41:50Z2021Leonhard SE, Halstead S, Lant SB, Militão de Albuquerque MFP, de Brito CAA, de Albuquerque LBB, Ellul MA, de Oliveira França RF, Gourlay D, Griffiths MJ, de Miranda Henriques-Souza AM, de Morais Machado MÍ, Medialdea-Carrera R, Mehta R, da Paz Melo R, Mesquita SD, Moreira ÁJP, Pena LJ, Santos ML, Turtle L, Solomon T, Willison HJ, Jacobs BC, Brito Ferreira ML. Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. J Neurol Sci. 2021 Jan 15;420:117272. doi: 10.1016/j.jns.2020.117272. Epub 2020 Dec 14. PMID: 33360425.1878-5883https://www.arca.fiocruz.br/handle/icict/5769310.1016/j.jns.2020.117272engGuillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Glasgow, Department of Neurology and Institute of Infection, Immunity and Inflammation, Glasgow, UK. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Saúde Coletiva, Recife, Pernambuco, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Clinica , Recife, Brazil. Instituto de Medicina Integral Professor Fernando Figueira (IMIP) Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Virologia, Recife, Brasil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Hospital da Restauração, Departamento de Pediatria Neurologica, Recife, Brasil. Hospital da Restauração, Departamento de Neurologia Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK. Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.Objective: To determine the clinical phenotype of Guillain-Barré syndrome (GBS) after Zika virus (ZIKV) infection, the anti-glycolipid antibody signature, and the role of other circulating arthropod-borne viruses, we describe a cohort of GBS patients identified during ZIKV and chikungunya virus (CHIKV) outbreaks in Northeast Brazil. Methods: We prospectively recruited GBS patients from a regional neurology center in Northeast Brazil between December 2014 and February 2017. Serum and CSF were tested for ZIKV, CHIKV, and dengue virus (DENV), by RT-PCR and antibodies, and serum was tested for GBS-associated antibodies to glycolipids. Results: Seventy-one patients were identified. Forty-eight (68%) had laboratory evidence of a recent arbovirus infection; 25 (52%) ZIKV, 8 (17%) CHIKV, 1 (2%) DENV, and 14 (29%) ZIKV and CHIKV. Most patients with a recent arbovirus infection had motor and sensory symptoms (72%), a demyelinating electrophysiological subtype (67%) and a facial palsy (58%). Patients with a recent infection with ZIKV and CHIKV had a longer hospital admission and more frequent mechanical ventilation compared to the other patients. No specific anti-glycolipid antibody signature was identified in association with arbovirus infection, although significant antibody titres to GM1, GalC, LM1, and GalNAc-GD1a were found infrequently. Conclusion: A large proportion of cases had laboratory evidence of a recent infection with ZIKV or CHIKV, and recent infection with both viruses was found in almost one third of patients. Most patients with a recent arbovirus infection had a sensorimotor, demyelinating GBS. We did not find a specific anti-glycolipid antibody signature in association with arbovirus-related GBS.Guillain-Barr ́e syndromeZika virusChikungunya virusArbovirusNeuroinflammatory diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGuillain-Barr ́e syndrome during the Zika virus outbreak in Northeast Brazil.pdfGuillain-Barr ́e syndrome during the Zika virus outbreak in Northeast Brazil.pdfapplication/pdf1190223https://www.arca.fiocruz.br/bitstream/icict/57693/2/Guillain-Barr%20%cc%81e%20syndrome%20during%20the%20Zika%20virus%20outbreak%20in%20Northeast%20Brazil.pdf9a25aaded59b37e5432f220ea06a28deMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57693/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/576932023-05-22 12:09:47.68oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-22T15:09:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
title Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
spellingShingle Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
Leonhard SE
Guillain-Barr ́e syndrome
Zika virus
Chikungunya virus
Arbovirus
Neuroinflammatory disease
title_short Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
title_full Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
title_fullStr Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
title_full_unstemmed Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
title_sort Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
author Leonhard SE
author_facet Leonhard SE
Halstead S
Lant SB
Militão de Albuquerque MFP
de Brito CAA
de Albuquerque LBB
Ellul MA
de Oliveira França RF
Gourlay D
Griffiths MJ
de Miranda Henriques-Souza AM
de Morais Machado MÍ
Medialdea-Carrera R
Mehta R
da Paz Melo R
Mesquita SD
Moreira ÁJP
Pena LJ
Santos ML
Turtle L
Solomon T
Willison HJ
Jacobs BC
Brito Ferreira ML.
author_role author
author2 Halstead S
Lant SB
Militão de Albuquerque MFP
de Brito CAA
de Albuquerque LBB
Ellul MA
de Oliveira França RF
Gourlay D
Griffiths MJ
de Miranda Henriques-Souza AM
de Morais Machado MÍ
Medialdea-Carrera R
Mehta R
da Paz Melo R
Mesquita SD
Moreira ÁJP
Pena LJ
Santos ML
Turtle L
Solomon T
Willison HJ
Jacobs BC
Brito Ferreira ML.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Leonhard SE
Halstead S
Lant SB
Militão de Albuquerque MFP
de Brito CAA
de Albuquerque LBB
Ellul MA
de Oliveira França RF
Gourlay D
Griffiths MJ
de Miranda Henriques-Souza AM
de Morais Machado MÍ
Medialdea-Carrera R
Mehta R
da Paz Melo R
Mesquita SD
Moreira ÁJP
Pena LJ
Santos ML
Turtle L
Solomon T
Willison HJ
Jacobs BC
Brito Ferreira ML.
dc.subject.en.en_US.fl_str_mv Guillain-Barr ́e syndrome
Zika virus
Chikungunya virus
Arbovirus
Neuroinflammatory disease
topic Guillain-Barr ́e syndrome
Zika virus
Chikungunya virus
Arbovirus
Neuroinflammatory disease
description University of Glasgow, Department of Neurology and Institute of Infection, Immunity and Inflammation, Glasgow, UK. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Saúde Coletiva, Recife, Pernambuco, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Clinica , Recife, Brazil. Instituto de Medicina Integral Professor Fernando Figueira (IMIP) Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Virologia, Recife, Brasil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Hospital da Restauração, Departamento de Pediatria Neurologica, Recife, Brasil. Hospital da Restauração, Departamento de Neurologia Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK. Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2023-04-05T14:41:50Z
dc.date.available.fl_str_mv 2023-04-05T14:41:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv Leonhard SE, Halstead S, Lant SB, Militão de Albuquerque MFP, de Brito CAA, de Albuquerque LBB, Ellul MA, de Oliveira França RF, Gourlay D, Griffiths MJ, de Miranda Henriques-Souza AM, de Morais Machado MÍ, Medialdea-Carrera R, Mehta R, da Paz Melo R, Mesquita SD, Moreira ÁJP, Pena LJ, Santos ML, Turtle L, Solomon T, Willison HJ, Jacobs BC, Brito Ferreira ML. Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. J Neurol Sci. 2021 Jan 15;420:117272. doi: 10.1016/j.jns.2020.117272. Epub 2020 Dec 14. PMID: 33360425.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57693
dc.identifier.issn.en_US.fl_str_mv 1878-5883
dc.identifier.doi.none.fl_str_mv 10.1016/j.jns.2020.117272
identifier_str_mv Leonhard SE, Halstead S, Lant SB, Militão de Albuquerque MFP, de Brito CAA, de Albuquerque LBB, Ellul MA, de Oliveira França RF, Gourlay D, Griffiths MJ, de Miranda Henriques-Souza AM, de Morais Machado MÍ, Medialdea-Carrera R, Mehta R, da Paz Melo R, Mesquita SD, Moreira ÁJP, Pena LJ, Santos ML, Turtle L, Solomon T, Willison HJ, Jacobs BC, Brito Ferreira ML. Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. J Neurol Sci. 2021 Jan 15;420:117272. doi: 10.1016/j.jns.2020.117272. Epub 2020 Dec 14. PMID: 33360425.
1878-5883
10.1016/j.jns.2020.117272
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