Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57693 |
Resumo: | University of Glasgow, Department of Neurology and Institute of Infection, Immunity and Inflammation, Glasgow, UK. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Saúde Coletiva, Recife, Pernambuco, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Clinica , Recife, Brazil. Instituto de Medicina Integral Professor Fernando Figueira (IMIP) Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Virologia, Recife, Brasil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Hospital da Restauração, Departamento de Pediatria Neurologica, Recife, Brasil. Hospital da Restauração, Departamento de Neurologia Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK. Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands. |
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Leonhard SEHalstead SLant SBMilitão de Albuquerque MFPde Brito CAAde Albuquerque LBBEllul MAde Oliveira França RFGourlay DGriffiths MJde Miranda Henriques-Souza AMde Morais Machado MÍMedialdea-Carrera RMehta Rda Paz Melo RMesquita SDMoreira ÁJPPena LJSantos MLTurtle LSolomon TWillison HJJacobs BCBrito Ferreira ML.2023-04-05T14:41:50Z2023-04-05T14:41:50Z2021Leonhard SE, Halstead S, Lant SB, Militão de Albuquerque MFP, de Brito CAA, de Albuquerque LBB, Ellul MA, de Oliveira França RF, Gourlay D, Griffiths MJ, de Miranda Henriques-Souza AM, de Morais Machado MÍ, Medialdea-Carrera R, Mehta R, da Paz Melo R, Mesquita SD, Moreira ÁJP, Pena LJ, Santos ML, Turtle L, Solomon T, Willison HJ, Jacobs BC, Brito Ferreira ML. Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. J Neurol Sci. 2021 Jan 15;420:117272. doi: 10.1016/j.jns.2020.117272. Epub 2020 Dec 14. PMID: 33360425.1878-5883https://www.arca.fiocruz.br/handle/icict/5769310.1016/j.jns.2020.117272engGuillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Glasgow, Department of Neurology and Institute of Infection, Immunity and Inflammation, Glasgow, UK. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Saúde Coletiva, Recife, Pernambuco, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Clinica , Recife, Brazil. Instituto de Medicina Integral Professor Fernando Figueira (IMIP) Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Virologia, Recife, Brasil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Hospital da Restauração, Departamento de Pediatria Neurologica, Recife, Brasil. Hospital da Restauração, Departamento de Neurologia Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK. Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.Objective: To determine the clinical phenotype of Guillain-Barré syndrome (GBS) after Zika virus (ZIKV) infection, the anti-glycolipid antibody signature, and the role of other circulating arthropod-borne viruses, we describe a cohort of GBS patients identified during ZIKV and chikungunya virus (CHIKV) outbreaks in Northeast Brazil. Methods: We prospectively recruited GBS patients from a regional neurology center in Northeast Brazil between December 2014 and February 2017. Serum and CSF were tested for ZIKV, CHIKV, and dengue virus (DENV), by RT-PCR and antibodies, and serum was tested for GBS-associated antibodies to glycolipids. Results: Seventy-one patients were identified. Forty-eight (68%) had laboratory evidence of a recent arbovirus infection; 25 (52%) ZIKV, 8 (17%) CHIKV, 1 (2%) DENV, and 14 (29%) ZIKV and CHIKV. Most patients with a recent arbovirus infection had motor and sensory symptoms (72%), a demyelinating electrophysiological subtype (67%) and a facial palsy (58%). Patients with a recent infection with ZIKV and CHIKV had a longer hospital admission and more frequent mechanical ventilation compared to the other patients. No specific anti-glycolipid antibody signature was identified in association with arbovirus infection, although significant antibody titres to GM1, GalC, LM1, and GalNAc-GD1a were found infrequently. Conclusion: A large proportion of cases had laboratory evidence of a recent infection with ZIKV or CHIKV, and recent infection with both viruses was found in almost one third of patients. Most patients with a recent arbovirus infection had a sensorimotor, demyelinating GBS. We did not find a specific anti-glycolipid antibody signature in association with arbovirus-related GBS.Guillain-Barr ́e syndromeZika virusChikungunya virusArbovirusNeuroinflammatory diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGuillain-Barr ́e syndrome during the Zika virus outbreak in Northeast Brazil.pdfGuillain-Barr ́e syndrome during the Zika virus outbreak in Northeast Brazil.pdfapplication/pdf1190223https://www.arca.fiocruz.br/bitstream/icict/57693/2/Guillain-Barr%20%cc%81e%20syndrome%20during%20the%20Zika%20virus%20outbreak%20in%20Northeast%20Brazil.pdf9a25aaded59b37e5432f220ea06a28deMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57693/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/576932023-05-22 12:09:47.68oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-22T15:09:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.en_US.fl_str_mv |
Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study |
title |
Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study |
spellingShingle |
Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study Leonhard SE Guillain-Barr ́e syndrome Zika virus Chikungunya virus Arbovirus Neuroinflammatory disease |
title_short |
Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study |
title_full |
Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study |
title_fullStr |
Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study |
title_full_unstemmed |
Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study |
title_sort |
Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study |
author |
Leonhard SE |
author_facet |
Leonhard SE Halstead S Lant SB Militão de Albuquerque MFP de Brito CAA de Albuquerque LBB Ellul MA de Oliveira França RF Gourlay D Griffiths MJ de Miranda Henriques-Souza AM de Morais Machado MÍ Medialdea-Carrera R Mehta R da Paz Melo R Mesquita SD Moreira ÁJP Pena LJ Santos ML Turtle L Solomon T Willison HJ Jacobs BC Brito Ferreira ML. |
author_role |
author |
author2 |
Halstead S Lant SB Militão de Albuquerque MFP de Brito CAA de Albuquerque LBB Ellul MA de Oliveira França RF Gourlay D Griffiths MJ de Miranda Henriques-Souza AM de Morais Machado MÍ Medialdea-Carrera R Mehta R da Paz Melo R Mesquita SD Moreira ÁJP Pena LJ Santos ML Turtle L Solomon T Willison HJ Jacobs BC Brito Ferreira ML. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Leonhard SE Halstead S Lant SB Militão de Albuquerque MFP de Brito CAA de Albuquerque LBB Ellul MA de Oliveira França RF Gourlay D Griffiths MJ de Miranda Henriques-Souza AM de Morais Machado MÍ Medialdea-Carrera R Mehta R da Paz Melo R Mesquita SD Moreira ÁJP Pena LJ Santos ML Turtle L Solomon T Willison HJ Jacobs BC Brito Ferreira ML. |
dc.subject.en.en_US.fl_str_mv |
Guillain-Barr ́e syndrome Zika virus Chikungunya virus Arbovirus Neuroinflammatory disease |
topic |
Guillain-Barr ́e syndrome Zika virus Chikungunya virus Arbovirus Neuroinflammatory disease |
description |
University of Glasgow, Department of Neurology and Institute of Infection, Immunity and Inflammation, Glasgow, UK. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Saúde Coletiva, Recife, Pernambuco, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Clinica , Recife, Brazil. Instituto de Medicina Integral Professor Fernando Figueira (IMIP) Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Virologia, Recife, Brasil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Hospital da Restauração, Departamento de Pediatria Neurologica, Recife, Brasil. Hospital da Restauração, Departamento de Neurologia Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK. Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2023-04-05T14:41:50Z |
dc.date.available.fl_str_mv |
2023-04-05T14:41:50Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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dc.identifier.citation.fl_str_mv |
Leonhard SE, Halstead S, Lant SB, Militão de Albuquerque MFP, de Brito CAA, de Albuquerque LBB, Ellul MA, de Oliveira França RF, Gourlay D, Griffiths MJ, de Miranda Henriques-Souza AM, de Morais Machado MÍ, Medialdea-Carrera R, Mehta R, da Paz Melo R, Mesquita SD, Moreira ÁJP, Pena LJ, Santos ML, Turtle L, Solomon T, Willison HJ, Jacobs BC, Brito Ferreira ML. Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. J Neurol Sci. 2021 Jan 15;420:117272. doi: 10.1016/j.jns.2020.117272. Epub 2020 Dec 14. PMID: 33360425. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/57693 |
dc.identifier.issn.en_US.fl_str_mv |
1878-5883 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.jns.2020.117272 |
identifier_str_mv |
Leonhard SE, Halstead S, Lant SB, Militão de Albuquerque MFP, de Brito CAA, de Albuquerque LBB, Ellul MA, de Oliveira França RF, Gourlay D, Griffiths MJ, de Miranda Henriques-Souza AM, de Morais Machado MÍ, Medialdea-Carrera R, Mehta R, da Paz Melo R, Mesquita SD, Moreira ÁJP, Pena LJ, Santos ML, Turtle L, Solomon T, Willison HJ, Jacobs BC, Brito Ferreira ML. Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. J Neurol Sci. 2021 Jan 15;420:117272. doi: 10.1016/j.jns.2020.117272. Epub 2020 Dec 14. PMID: 33360425. 1878-5883 10.1016/j.jns.2020.117272 |
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https://www.arca.fiocruz.br/handle/icict/57693 |
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