Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease

Detalhes bibliográficos
Autor(a) principal: Feijó, Daniel
Data de Publicação: 2016
Outros Autores: Tibúrcio, Rafael, Ampuero, Mariana, Brodskyn, Claudia Ida, Tavares, Natalia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14833
Resumo: Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Feijó, DanielTibúrcio, RafaelAmpuero, MarianaBrodskyn, Claudia IdaTavares, Natalia2016-07-13T11:40:36Z2016-07-13T11:40:36Z2016FEIJÓ, D. et al. Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease. Journal of Immunology Research, p. 1-9, 2016.2314-8861https://www.arca.fiocruz.br/handle/icict/14833dx.doi.org/10.1155/2016/3967436engHindawi Publishing CorporationDendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto de Investigação em Imunologia (iii). São Paulo, SP, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilIt is an important public health problem worldwide caused by the protozoan parasite from the Leishmania genus. Cutaneous Leishmaniasis (CL) is the most frequent form of this disease transmitted by the bite of an infected sandfly into the host skin. The parasites can be uptook and/or recognized by macrophages, neutrophils, and/or dendritic cells (DCs). Initially, DCs were described to play a protective role in activating the immune response against Leishmania parasites.However, several reports showed a dichotomic role of DCs in modulating the host immune response to susceptibility or resistance in CL. In this review, we discuss (1) the interactions between DCs and parasites from different species of Leishmania and (2) the crosstalk of DCs and other cells during CL infection.The complexity of these interactions profoundly affects the adaptive immune response and, consequently, the disease outcome, especially from Leishmania species of the NewWorldLeishmaniaParasitesNeglected DiseasesCutaneous LeishmaniasisPhlebotomusDendritic CellsAnimalsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14833/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFeijo D Dendritic cells....pdfFeijo D Dendritic cells....pdfapplication/pdf1000512https://www.arca.fiocruz.br/bitstream/icict/14833/2/Feijo%20D%20Dendritic%20cells....pdf590b72555d449e42f9d156b8e378dcf1MD52TEXTFeijo D Dendritic cells....pdf.txtFeijo 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dc.title.pt_BR.fl_str_mv Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
title Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
spellingShingle Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
Feijó, Daniel
Leishmania
Parasites
Neglected Diseases
Cutaneous Leishmaniasis
Phlebotomus
Dendritic Cells
Animals
title_short Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
title_full Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
title_fullStr Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
title_full_unstemmed Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
title_sort Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
author Feijó, Daniel
author_facet Feijó, Daniel
Tibúrcio, Rafael
Ampuero, Mariana
Brodskyn, Claudia Ida
Tavares, Natalia
author_role author
author2 Tibúrcio, Rafael
Ampuero, Mariana
Brodskyn, Claudia Ida
Tavares, Natalia
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Feijó, Daniel
Tibúrcio, Rafael
Ampuero, Mariana
Brodskyn, Claudia Ida
Tavares, Natalia
dc.subject.en.pt_BR.fl_str_mv Leishmania
Parasites
Neglected Diseases
Cutaneous Leishmaniasis
Phlebotomus
Dendritic Cells
Animals
topic Leishmania
Parasites
Neglected Diseases
Cutaneous Leishmaniasis
Phlebotomus
Dendritic Cells
Animals
description Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-07-13T11:40:36Z
dc.date.available.fl_str_mv 2016-07-13T11:40:36Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FEIJÓ, D. et al. Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease. Journal of Immunology Research, p. 1-9, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14833
dc.identifier.issn.pt_BR.fl_str_mv 2314-8861
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1155/2016/3967436
identifier_str_mv FEIJÓ, D. et al. Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease. Journal of Immunology Research, p. 1-9, 2016.
2314-8861
dx.doi.org/10.1155/2016/3967436
url https://www.arca.fiocruz.br/handle/icict/14833
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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