CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.

Campanelli, Ana Paula; Roselino, Ana Maria Ferreira; Cavassani, Karen Angélica; Pereira, Marcelo de Souza Fernandes; Mortara, Renato Arruda; Brodskyn, Claudia Ida; Gonçalves, Heitor de Sá; Belkaid, Yasmine; Barral Netto, Manoel; Barral, Aldina Maria Prado; Silva, João Santana da

CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.

Detalhes bibliográficos
Autor(a) principal:	Campanelli, Ana Paula
Data de Publicação:	2006
Outros Autores:	Roselino, Ana Maria Ferreira, Cavassani, Karen Angélica, Pereira, Marcelo de Souza Fernandes, Mortara, Renato Arruda, Brodskyn, Claudia Ida, Gonçalves, Heitor de Sá, Belkaid, Yasmine, Barral Netto, Manoel, Barral, Aldina Maria Prado, Silva, João Santana da
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/7413
Resumo:	University of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, Brasil

Metadados do item

id	CRUZ_d483d41ea5b5f3a6cb9077bbd379b816
oai_identifier_str	oai:www.arca.fiocruz.br:icict/7413
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Campanelli, Ana PaulaRoselino, Ana Maria FerreiraCavassani, Karen AngélicaPereira, Marcelo de Souza FernandesMortara, Renato ArrudaBrodskyn, Claudia IdaGonçalves, Heitor de SáBelkaid, YasmineBarral Netto, ManoelBarral, Aldina Maria PradoSilva, João Santana da2014-03-17T18:36:18Z2014-03-17T18:36:18Z2006CAMPANELLI, A. P. et al. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. The Journal of Infectious Diseases, v. 193, n. 9, p. 1313–1322, 2006.0022-1899https://www.arca.fiocruz.br/handle/icict/7413engthe Infectious Diseases Society of America.CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, BrasilUniversity of São Paulo. School of Medicine of Ribeirão Preto. Division of Dermatology. Ribeirão Preto, SP, BrasilUniversity of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, BrasilUniversity of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, BrasilUniversidade Federal de São Paulo. Department of Microbiology, Immunology, and Parasitology. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute of Investigation in Immunology. Salvador, BA, BrasilCenter for Dermatology Dona Libânia. Fortaleza, CE, BrasilNational Institutes of Health. Mucosal Immunology Unit. Laboratory of Parasitic Diseases. Bethesda, MDFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute of Investigation in Immunology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute of Investigation in Immunology. Salvador, BA, BrasilUniversity of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, BrasilEndogenous regulatory T (Treg) cells are involved in the control of infections, including Leishmania infection in mice. Leishmania viannia braziliensis is the main etiologic agent of cutaneous leishmaniasis (CL) in Brazil, and it is also responsible for the more severe mucocutaneous form. Here, we investigated the possible involvement of Treg cells in the control of the immune response in human skin lesions caused by L. viannia braziliensis infection. We show that functional Treg cells can be found in skin lesions of patients with CL. These cells express phenotypic markers of Treg cells—such as CD25, cytotoxic T lymphocyte–associated antigen 4, Foxp3, and glucocorticoid-induced tumor necrosis factor receptor—and are able to produce large amounts of interleukin-10 and transforming growth factor–b. Furthermore, CD4+CD25+ T cells derived from the skin lesions of 4 of 6 patients with CL significantly suppressed in vitro the phytohemagglutinin-inducedproliferative T cell responses of allogeneic peripheral-blood mononuclear cells (PBMCs) from healthy control subjects at a ratio of 1 Treg cell to 10 allogeneic PBMCs. These findings suggest that functional Treg cells accumulate at sites of Leishmania infection in humans and possibly contribute to the local control of effector T cell functionsAntígenos CD4/análiseLeishmania braziliensisLeishmaniose Cutânea/imunologiaReceptores de Interleucina-2/análisePele/imunologiaLinfócitos T Reguladores/imunologiaAdolescenteAdultoIdosoAnimaisQuimiocinas CC/metabolismoCriançaFemininoFatores de Transcrição Forkhead/metabolismoHumanosImunossupressãoInterleucina-10/metabolismoLeishmaniose Cutânea/patologiaAtivação LinfocitáriaMasculinoMeia-IdadeFenótipoReceptores CCR4Receptores de Quimiocinas/metabolismoPele/microbiologiaPele/patologiaLinfócitos T Reguladores/citologiaFator de Crescimento Transformador beta/metabolismoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCampanelli A P CD4+CD25+ T Cells in....pdfCampanelli A P CD4+CD25+ T Cells in....pdfapplication/pdf2074128https://www.arca.fiocruz.br/bitstream/icict/7413/1/Campanelli%20A%20P%20CD4%2bCD25%2b%20T%20Cells%20in....pdfc5b1f23f8aa94910fe069d156cedea6eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7413/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCampanelli A P CD4+CD25+ T Cells in....pdf.txtCampanelli A P CD4+CD25+ T Cells in....pdf.txtExtracted texttext/plain44965https://www.arca.fiocruz.br/bitstream/icict/7413/5/Campanelli%20A%20P%20CD4%2bCD25%2b%20T%20Cells%20in....pdf.txt16de513324c1998ba5b4725e0c53ad69MD55THUMBNAILCampanelli A P CD4+CD25+ T Cells in....pdf.jpgCampanelli A P CD4+CD25+ T Cells in....pdf.jpgGenerated Thumbnailimage/jpeg2344https://www.arca.fiocruz.br/bitstream/icict/7413/4/Campanelli%20A%20P%20CD4%2bCD25%2b%20T%20Cells%20in....pdf.jpg6bce7aca0862e5a4873a61f3a79ef87aMD54icict/74132023-03-15 14:33:21.781oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.
title	CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.
spellingShingle	CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. Campanelli, Ana Paula Antígenos CD4/análise Leishmania braziliensis Leishmaniose Cutânea/imunologia Receptores de Interleucina-2/análise Pele/imunologia Linfócitos T Reguladores/imunologia Adolescente Adulto Idoso Animais Quimiocinas CC/metabolismo Criança Feminino Fatores de Transcrição Forkhead/metabolismo Humanos Imunossupressão Interleucina-10/metabolismo Leishmaniose Cutânea/patologia Ativação Linfocitária Masculino Meia-Idade Fenótipo Receptores CCR4 Receptores de Quimiocinas/metabolismo Pele/microbiologia Pele/patologia Linfócitos T Reguladores/citologia Fator de Crescimento Transformador beta/metabolismo
title_short	CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.
title_full	CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.
title_fullStr	CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.
title_full_unstemmed	CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.
title_sort	CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.
author	Campanelli, Ana Paula
author_facet	Campanelli, Ana Paula Roselino, Ana Maria Ferreira Cavassani, Karen Angélica Pereira, Marcelo de Souza Fernandes Mortara, Renato Arruda Brodskyn, Claudia Ida Gonçalves, Heitor de Sá Belkaid, Yasmine Barral Netto, Manoel Barral, Aldina Maria Prado Silva, João Santana da
author_role	author
author2	Roselino, Ana Maria Ferreira Cavassani, Karen Angélica Pereira, Marcelo de Souza Fernandes Mortara, Renato Arruda Brodskyn, Claudia Ida Gonçalves, Heitor de Sá Belkaid, Yasmine Barral Netto, Manoel Barral, Aldina Maria Prado Silva, João Santana da
author2_role	author author author author author author author author author author
dc.contributor.author.fl_str_mv	Campanelli, Ana Paula Roselino, Ana Maria Ferreira Cavassani, Karen Angélica Pereira, Marcelo de Souza Fernandes Mortara, Renato Arruda Brodskyn, Claudia Ida Gonçalves, Heitor de Sá Belkaid, Yasmine Barral Netto, Manoel Barral, Aldina Maria Prado Silva, João Santana da
dc.subject.decs.pt_BR.fl_str_mv	Antígenos CD4/análise Leishmania braziliensis Leishmaniose Cutânea/imunologia Receptores de Interleucina-2/análise Pele/imunologia Linfócitos T Reguladores/imunologia Adolescente Adulto Idoso Animais Quimiocinas CC/metabolismo Criança Feminino Fatores de Transcrição Forkhead/metabolismo Humanos Imunossupressão Interleucina-10/metabolismo Leishmaniose Cutânea/patologia Ativação Linfocitária Masculino Meia-Idade Fenótipo Receptores CCR4 Receptores de Quimiocinas/metabolismo Pele/microbiologia Pele/patologia Linfócitos T Reguladores/citologia Fator de Crescimento Transformador beta/metabolismo
topic	Antígenos CD4/análise Leishmania braziliensis Leishmaniose Cutânea/imunologia Receptores de Interleucina-2/análise Pele/imunologia Linfócitos T Reguladores/imunologia Adolescente Adulto Idoso Animais Quimiocinas CC/metabolismo Criança Feminino Fatores de Transcrição Forkhead/metabolismo Humanos Imunossupressão Interleucina-10/metabolismo Leishmaniose Cutânea/patologia Ativação Linfocitária Masculino Meia-Idade Fenótipo Receptores CCR4 Receptores de Quimiocinas/metabolismo Pele/microbiologia Pele/patologia Linfócitos T Reguladores/citologia Fator de Crescimento Transformador beta/metabolismo
description	University of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, Brasil
publishDate	2006
dc.date.issued.fl_str_mv	2006
dc.date.accessioned.fl_str_mv	2014-03-17T18:36:18Z
dc.date.available.fl_str_mv	2014-03-17T18:36:18Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	CAMPANELLI, A. P. et al. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. The Journal of Infectious Diseases, v. 193, n. 9, p. 1313–1322, 2006.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/7413
dc.identifier.issn.none.fl_str_mv	0022-1899
identifier_str_mv	CAMPANELLI, A. P. et al. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. The Journal of Infectious Diseases, v. 193, n. 9, p. 1313–1322, 2006. 0022-1899
url	https://www.arca.fiocruz.br/handle/icict/7413
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	the Infectious Diseases Society of America.
publisher.none.fl_str_mv	the Infectious Diseases Society of America.
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/7413/1/Campanelli%20A%20P%20CD4%2bCD25%2b%20T%20Cells%20in....pdf https://www.arca.fiocruz.br/bitstream/icict/7413/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/7413/5/Campanelli%20A%20P%20CD4%2bCD25%2b%20T%20Cells%20in....pdf.txt https://www.arca.fiocruz.br/bitstream/icict/7413/4/Campanelli%20A%20P%20CD4%2bCD25%2b%20T%20Cells%20in....pdf.jpg
bitstream.checksum.fl_str_mv	c5b1f23f8aa94910fe069d156cedea6e 7d48279ffeed55da8dfe2f8e81f3b81f 16de513324c1998ba5b4725e0c53ad69 6bce7aca0862e5a4873a61f3a79ef87a
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1813008845775044608

CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.

Registros relacionados