Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens

Detalhes bibliográficos
Autor(a) principal: Secor, William E
Data de Publicação: 1994
Outros Autores: Reis, Mitermayer Galvão dos, Ramos, Eduardo Antônio Gonçalves, Matos, E. Peixoto, Reis, Eliana Almeida Gomes, Carmo, Theomira Mauadie de Azevedo, Harn Junior, Donald A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7579
Resumo: Department of Tropical Public Health. Harvard School of Public Health. Boston, Massachusetts
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spelling Secor, William EReis, Mitermayer Galvão dosRamos, Eduardo Antônio GonçalvesMatos, E. PeixotoReis, Eliana Almeida GomesCarmo, Theomira Mauadie de AzevedoHarn Junior, Donald A2014-05-05T18:56:29Z2014-05-05T18:56:29Z1994SECOR W. E. et al. Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens. Infection and Immunity, v. 62, n. 7, p. 2695-2701, 1994.0019-9567https://www.arca.fiocruz.br/handle/icict/7579engAmerican Society for MicrobiologySoluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigensinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Tropical Public Health. Harvard School of Public Health. Boston, MassachusettsFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHospital Roberto Santos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilDepartment of Tropical Public Health. Harvard School of Public Health. Boston, MassachusettsGranuloma formation, the principal pathologic consequence of infection with Schistosoma mansoni, is a complex process involving intricate cell-cell interactions in which intercellular adhesion molecules are likely to participate. To examine this possibility, sera of schistosomiasis patients in various clinical groups were assayed for the presence of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin). Comparisons were made between groups with different infection intensities (as predicted by fecal egg count) as well as between groups with severe (hepatosplenic) or milder (intestinal) pathology. All groups had elevated levels of sICAM-1 compared with controls. Also, patients in the high egg-excreting and hepatosplenic groups had significantly higher levels of serum sICAM-1 than patients in the low-egg-excreting and intestinal groups, respectively. The levels of sE-selectin were significantly elevated in the sera of all patients except those in the hepatosplenic group compared with controls. Patients in the intestinal group had significantly higher levels of sE-selectin in their sera than did hepatosplenic group patients, but serum sE-selectin levels of high- and low-egg-excreting patients were comparable. A striking finding of this study was the inverse correlation observed between sICAM-1 levels and peripheral blood mononuclear cell responses to schistosome soluble egg antigens (SEA) but not with responses to other schistosome antigens, purified protein derivative, or mitogen. Because ICAM-1 can perform a costimulatory function in antigen-presenting cell-T cell interactions, it is possible that shedding of ICAM-1 in the granuloma microenvironment interrupts proper costimulation, leading to unresponsive SEA-specific T cells. In this way, sICAM-1 could be one factor contributing to the observed modulation of cellular responses to SEA in chronic human schistosomiasis.Antígenos de Helmintos/imunologiaMoléculas de Adesão Celular/sangueProteínas do Ovo/imunologiaGranuloma/etiologiaEsquistossomose/metabolismoAdolescenteAdultoAnimaisMoléculas de Adesão Celular/imunologiaCriançaPré-EscolarSelectina EFemininoHumanosMolécula 1 de Adesão IntercelularAtivação LinfocitáriaMasculinoMeia-IdadeContagem de Ovos de ParasitasSchistosomaEsquistossomose/complicaçõesEsquistossomose/imunologiaSolubilidadeFator de Necrose Tumoral alfa/análiseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSecor WE Soluble intercellular adhesion....pdfSecor WE Soluble intercellular adhesion....pdfapplication/pdf1644417https://www.arca.fiocruz.br/bitstream/icict/7579/1/Secor%20WE%20Soluble%20intercellular%20adhesion....pdf95df99a0bb241f81b1733640ea9eec13MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7579/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSecor WE Soluble intercellular adhesion....pdf.txtSecor WE Soluble intercellular adhesion....pdf.txtExtracted texttext/plain45012https://www.arca.fiocruz.br/bitstream/icict/7579/5/Secor%20WE%20Soluble%20intercellular%20adhesion....pdf.txt1041f301bf5a34f347b2d0dd9dd5f842MD55THUMBNAILSecor WE Soluble intercellular adhesion....pdf.jpgSecor WE Soluble intercellular adhesion....pdf.jpgGenerated Thumbnailimage/jpeg2336https://www.arca.fiocruz.br/bitstream/icict/7579/4/Secor%20WE%20Soluble%20intercellular%20adhesion....pdf.jpg535f4008e2feae661335dc45ca5ee0baMD54icict/75792023-03-15 14:33:05.737oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens
title Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens
spellingShingle Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens
Secor, William E
Antígenos de Helmintos/imunologia
Moléculas de Adesão Celular/sangue
Proteínas do Ovo/imunologia
Granuloma/etiologia
Esquistossomose/metabolismo
Adolescente
Adulto
Animais
Moléculas de Adesão Celular/imunologia
Criança
Pré-Escolar
Selectina E
Feminino
Humanos
Molécula 1 de Adesão Intercelular
Ativação Linfocitária
Masculino
Meia-Idade
Contagem de Ovos de Parasitas
Schistosoma
Esquistossomose/complicações
Esquistossomose/imunologia
Solubilidade
Fator de Necrose Tumoral alfa/análise
title_short Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens
title_full Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens
title_fullStr Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens
title_full_unstemmed Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens
title_sort Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens
author Secor, William E
author_facet Secor, William E
Reis, Mitermayer Galvão dos
Ramos, Eduardo Antônio Gonçalves
Matos, E. Peixoto
Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Harn Junior, Donald A
author_role author
author2 Reis, Mitermayer Galvão dos
Ramos, Eduardo Antônio Gonçalves
Matos, E. Peixoto
Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Harn Junior, Donald A
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Secor, William E
Reis, Mitermayer Galvão dos
Ramos, Eduardo Antônio Gonçalves
Matos, E. Peixoto
Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Harn Junior, Donald A
dc.subject.decs.pt_BR.fl_str_mv Antígenos de Helmintos/imunologia
Moléculas de Adesão Celular/sangue
Proteínas do Ovo/imunologia
Granuloma/etiologia
Esquistossomose/metabolismo
Adolescente
Adulto
Animais
Moléculas de Adesão Celular/imunologia
Criança
Pré-Escolar
Selectina E
Feminino
Humanos
Molécula 1 de Adesão Intercelular
Ativação Linfocitária
Masculino
Meia-Idade
Contagem de Ovos de Parasitas
Schistosoma
Esquistossomose/complicações
Esquistossomose/imunologia
Solubilidade
Fator de Necrose Tumoral alfa/análise
topic Antígenos de Helmintos/imunologia
Moléculas de Adesão Celular/sangue
Proteínas do Ovo/imunologia
Granuloma/etiologia
Esquistossomose/metabolismo
Adolescente
Adulto
Animais
Moléculas de Adesão Celular/imunologia
Criança
Pré-Escolar
Selectina E
Feminino
Humanos
Molécula 1 de Adesão Intercelular
Ativação Linfocitária
Masculino
Meia-Idade
Contagem de Ovos de Parasitas
Schistosoma
Esquistossomose/complicações
Esquistossomose/imunologia
Solubilidade
Fator de Necrose Tumoral alfa/análise
description Department of Tropical Public Health. Harvard School of Public Health. Boston, Massachusetts
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2014-05-05T18:56:29Z
dc.date.available.fl_str_mv 2014-05-05T18:56:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SECOR W. E. et al. Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens. Infection and Immunity, v. 62, n. 7, p. 2695-2701, 1994.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7579
dc.identifier.issn.none.fl_str_mv 0019-9567
identifier_str_mv SECOR W. E. et al. Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens. Infection and Immunity, v. 62, n. 7, p. 2695-2701, 1994.
0019-9567
url https://www.arca.fiocruz.br/handle/icict/7579
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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