Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7579 |
Resumo: | Department of Tropical Public Health. Harvard School of Public Health. Boston, Massachusetts |
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Secor, William EReis, Mitermayer Galvão dosRamos, Eduardo Antônio GonçalvesMatos, E. PeixotoReis, Eliana Almeida GomesCarmo, Theomira Mauadie de AzevedoHarn Junior, Donald A2014-05-05T18:56:29Z2014-05-05T18:56:29Z1994SECOR W. E. et al. Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens. Infection and Immunity, v. 62, n. 7, p. 2695-2701, 1994.0019-9567https://www.arca.fiocruz.br/handle/icict/7579engAmerican Society for MicrobiologySoluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigensinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Tropical Public Health. Harvard School of Public Health. Boston, MassachusettsFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHospital Roberto Santos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilDepartment of Tropical Public Health. Harvard School of Public Health. Boston, MassachusettsGranuloma formation, the principal pathologic consequence of infection with Schistosoma mansoni, is a complex process involving intricate cell-cell interactions in which intercellular adhesion molecules are likely to participate. To examine this possibility, sera of schistosomiasis patients in various clinical groups were assayed for the presence of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin). Comparisons were made between groups with different infection intensities (as predicted by fecal egg count) as well as between groups with severe (hepatosplenic) or milder (intestinal) pathology. All groups had elevated levels of sICAM-1 compared with controls. Also, patients in the high egg-excreting and hepatosplenic groups had significantly higher levels of serum sICAM-1 than patients in the low-egg-excreting and intestinal groups, respectively. The levels of sE-selectin were significantly elevated in the sera of all patients except those in the hepatosplenic group compared with controls. Patients in the intestinal group had significantly higher levels of sE-selectin in their sera than did hepatosplenic group patients, but serum sE-selectin levels of high- and low-egg-excreting patients were comparable. A striking finding of this study was the inverse correlation observed between sICAM-1 levels and peripheral blood mononuclear cell responses to schistosome soluble egg antigens (SEA) but not with responses to other schistosome antigens, purified protein derivative, or mitogen. Because ICAM-1 can perform a costimulatory function in antigen-presenting cell-T cell interactions, it is possible that shedding of ICAM-1 in the granuloma microenvironment interrupts proper costimulation, leading to unresponsive SEA-specific T cells. In this way, sICAM-1 could be one factor contributing to the observed modulation of cellular responses to SEA in chronic human schistosomiasis.Antígenos de Helmintos/imunologiaMoléculas de Adesão Celular/sangueProteínas do Ovo/imunologiaGranuloma/etiologiaEsquistossomose/metabolismoAdolescenteAdultoAnimaisMoléculas de Adesão Celular/imunologiaCriançaPré-EscolarSelectina EFemininoHumanosMolécula 1 de Adesão IntercelularAtivação LinfocitáriaMasculinoMeia-IdadeContagem de Ovos de ParasitasSchistosomaEsquistossomose/complicaçõesEsquistossomose/imunologiaSolubilidadeFator de Necrose Tumoral alfa/análiseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSecor WE Soluble intercellular adhesion....pdfSecor WE Soluble intercellular adhesion....pdfapplication/pdf1644417https://www.arca.fiocruz.br/bitstream/icict/7579/1/Secor%20WE%20Soluble%20intercellular%20adhesion....pdf95df99a0bb241f81b1733640ea9eec13MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7579/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSecor WE Soluble intercellular adhesion....pdf.txtSecor WE Soluble intercellular adhesion....pdf.txtExtracted texttext/plain45012https://www.arca.fiocruz.br/bitstream/icict/7579/5/Secor%20WE%20Soluble%20intercellular%20adhesion....pdf.txt1041f301bf5a34f347b2d0dd9dd5f842MD55THUMBNAILSecor WE Soluble intercellular adhesion....pdf.jpgSecor WE Soluble intercellular adhesion....pdf.jpgGenerated Thumbnailimage/jpeg2336https://www.arca.fiocruz.br/bitstream/icict/7579/4/Secor%20WE%20Soluble%20intercellular%20adhesion....pdf.jpg535f4008e2feae661335dc45ca5ee0baMD54icict/75792023-03-15 14:33:05.737oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens |
title |
Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens |
spellingShingle |
Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens Secor, William E Antígenos de Helmintos/imunologia Moléculas de Adesão Celular/sangue Proteínas do Ovo/imunologia Granuloma/etiologia Esquistossomose/metabolismo Adolescente Adulto Animais Moléculas de Adesão Celular/imunologia Criança Pré-Escolar Selectina E Feminino Humanos Molécula 1 de Adesão Intercelular Ativação Linfocitária Masculino Meia-Idade Contagem de Ovos de Parasitas Schistosoma Esquistossomose/complicações Esquistossomose/imunologia Solubilidade Fator de Necrose Tumoral alfa/análise |
title_short |
Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens |
title_full |
Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens |
title_fullStr |
Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens |
title_full_unstemmed |
Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens |
title_sort |
Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens |
author |
Secor, William E |
author_facet |
Secor, William E Reis, Mitermayer Galvão dos Ramos, Eduardo Antônio Gonçalves Matos, E. Peixoto Reis, Eliana Almeida Gomes Carmo, Theomira Mauadie de Azevedo Harn Junior, Donald A |
author_role |
author |
author2 |
Reis, Mitermayer Galvão dos Ramos, Eduardo Antônio Gonçalves Matos, E. Peixoto Reis, Eliana Almeida Gomes Carmo, Theomira Mauadie de Azevedo Harn Junior, Donald A |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Secor, William E Reis, Mitermayer Galvão dos Ramos, Eduardo Antônio Gonçalves Matos, E. Peixoto Reis, Eliana Almeida Gomes Carmo, Theomira Mauadie de Azevedo Harn Junior, Donald A |
dc.subject.decs.pt_BR.fl_str_mv |
Antígenos de Helmintos/imunologia Moléculas de Adesão Celular/sangue Proteínas do Ovo/imunologia Granuloma/etiologia Esquistossomose/metabolismo Adolescente Adulto Animais Moléculas de Adesão Celular/imunologia Criança Pré-Escolar Selectina E Feminino Humanos Molécula 1 de Adesão Intercelular Ativação Linfocitária Masculino Meia-Idade Contagem de Ovos de Parasitas Schistosoma Esquistossomose/complicações Esquistossomose/imunologia Solubilidade Fator de Necrose Tumoral alfa/análise |
topic |
Antígenos de Helmintos/imunologia Moléculas de Adesão Celular/sangue Proteínas do Ovo/imunologia Granuloma/etiologia Esquistossomose/metabolismo Adolescente Adulto Animais Moléculas de Adesão Celular/imunologia Criança Pré-Escolar Selectina E Feminino Humanos Molécula 1 de Adesão Intercelular Ativação Linfocitária Masculino Meia-Idade Contagem de Ovos de Parasitas Schistosoma Esquistossomose/complicações Esquistossomose/imunologia Solubilidade Fator de Necrose Tumoral alfa/análise |
description |
Department of Tropical Public Health. Harvard School of Public Health. Boston, Massachusetts |
publishDate |
1994 |
dc.date.issued.fl_str_mv |
1994 |
dc.date.accessioned.fl_str_mv |
2014-05-05T18:56:29Z |
dc.date.available.fl_str_mv |
2014-05-05T18:56:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SECOR W. E. et al. Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens. Infection and Immunity, v. 62, n. 7, p. 2695-2701, 1994. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7579 |
dc.identifier.issn.none.fl_str_mv |
0019-9567 |
identifier_str_mv |
SECOR W. E. et al. Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens. Infection and Immunity, v. 62, n. 7, p. 2695-2701, 1994. 0019-9567 |
url |
https://www.arca.fiocruz.br/handle/icict/7579 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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