High serum nitric oxide levels in patients with severe leptospirosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2787 |
Resumo: | Este trabalho foi financiado por doações da FINEP / PRONEX, Fundação Oswaldo Cruz, Conselho Nacional de Pesquisa, EUA National Institutes of Health e Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
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Maciel, Elves Anderson PiresAthanazio, Daniel AbensurReis, Eliana Almeida GomesCunha, Fernando QueirozQueiroz, AdrianoAlmeida, Deusdelia Teixeira deMcBride, Alan John AlexanderKo, Albert IcksangReis, Mitermayer Galvão dos2011-08-08T13:58:43Z2011-08-08T13:58:43Z2006MACIEL, E. A. P. et al. High serum nitric oxide levels in patients with severe leptospirosis. Acta Tropica, v.100, n.3, p.256–260, dez. 2006.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/2787Este trabalho foi financiado por doações da FINEP / PRONEX, Fundação Oswaldo Cruz, Conselho Nacional de Pesquisa, EUA National Institutes of Health e Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Weill Medical College of Cornell University. Division of International Medicine and Infectious Disease. New York, NY, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilLeptospirosis is a globally distributed zoonosis of major public health importance and is associated with severe disease manifestations such as acute renal failure and pulmonary haemorrhage syndrome. However, the extent to which the pathogenesis of leptospirosis mimics sepsis caused by Gramnegative bacteria remains unknown. The aim of this study was to evaluate serum levels of nitric oxide (NO) in patients diagnosed with severe leptospirosis. Sera from 35 confirmed cases of severe leptospirosis and 13 healthy subjects were analysed. Patients with severe leptospirosis had significantly higher NO levels compared to healthy individuals (30.82 ± 10.90 μM versus 3.86 ± 1.34 μM, P<0.001), indicating that this immune mediator plays a role in the underlying systemic inflammatory response.engElsevierLeptospiroseÓxido NítricoInsuficiência Renal AgudaHemorragia PulmonarLeptospirosisNitric OxideAcute renal failurePulmonary HaemorrhageAdolescenteAdultoIdosoMarcadores BiológicosBrasilFemininoFebreHumanosIcteríciaLeptospiroseMasculinoMeia-IdadeÓxido NítricoInsuficiência RespiratóriaChoqueHigh serum nitric oxide levels in patients with severe leptospirosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMaciel_Athanazio_Reis_etal.pdfMaciel_Athanazio_Reis_etal.pdfapplication/pdf142104https://www.arca.fiocruz.br/bitstream/icict/2787/1/Maciel_Athanazio_Reis_etal.pdfe11fbc17c0788fe27ff5743599182fb0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2787/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTMaciel_Athanazio_Reis_etal.pdf.txtMaciel_Athanazio_Reis_etal.pdf.txtExtracted texttext/plain24287https://www.arca.fiocruz.br/bitstream/icict/2787/5/Maciel_Athanazio_Reis_etal.pdf.txt15748afe458418513f6cc01283de1128MD55THUMBNAILMaciel_Athanazio_Reis_etal.pdf.jpgMaciel_Athanazio_Reis_etal.pdf.jpgGenerated Thumbnailimage/jpeg2379https://www.arca.fiocruz.br/bitstream/icict/2787/4/Maciel_Athanazio_Reis_etal.pdf.jpg5410c68d0c219e13244183c18cd064c6MD54icict/27872023-03-15 14:33:01.107oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
High serum nitric oxide levels in patients with severe leptospirosis |
| title |
High serum nitric oxide levels in patients with severe leptospirosis |
| spellingShingle |
High serum nitric oxide levels in patients with severe leptospirosis Maciel, Elves Anderson Pires Leptospirose Óxido Nítrico Insuficiência Renal Aguda Hemorragia Pulmonar Leptospirosis Nitric Oxide Acute renal failure Pulmonary Haemorrhage Adolescente Adulto Idoso Marcadores Biológicos Brasil Feminino Febre Humanos Icterícia Leptospirose Masculino Meia-Idade Óxido Nítrico Insuficiência Respiratória Choque |
| title_short |
High serum nitric oxide levels in patients with severe leptospirosis |
| title_full |
High serum nitric oxide levels in patients with severe leptospirosis |
| title_fullStr |
High serum nitric oxide levels in patients with severe leptospirosis |
| title_full_unstemmed |
High serum nitric oxide levels in patients with severe leptospirosis |
| title_sort |
High serum nitric oxide levels in patients with severe leptospirosis |
| author |
Maciel, Elves Anderson Pires |
| author_facet |
Maciel, Elves Anderson Pires Athanazio, Daniel Abensur Reis, Eliana Almeida Gomes Cunha, Fernando Queiroz Queiroz, Adriano Almeida, Deusdelia Teixeira de McBride, Alan John Alexander Ko, Albert Icksang Reis, Mitermayer Galvão dos |
| author_role |
author |
| author2 |
Athanazio, Daniel Abensur Reis, Eliana Almeida Gomes Cunha, Fernando Queiroz Queiroz, Adriano Almeida, Deusdelia Teixeira de McBride, Alan John Alexander Ko, Albert Icksang Reis, Mitermayer Galvão dos |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Maciel, Elves Anderson Pires Athanazio, Daniel Abensur Reis, Eliana Almeida Gomes Cunha, Fernando Queiroz Queiroz, Adriano Almeida, Deusdelia Teixeira de McBride, Alan John Alexander Ko, Albert Icksang Reis, Mitermayer Galvão dos |
| dc.subject.other.pt_BR.fl_str_mv |
Leptospirose Óxido Nítrico Insuficiência Renal Aguda Hemorragia Pulmonar |
| topic |
Leptospirose Óxido Nítrico Insuficiência Renal Aguda Hemorragia Pulmonar Leptospirosis Nitric Oxide Acute renal failure Pulmonary Haemorrhage Adolescente Adulto Idoso Marcadores Biológicos Brasil Feminino Febre Humanos Icterícia Leptospirose Masculino Meia-Idade Óxido Nítrico Insuficiência Respiratória Choque |
| dc.subject.en.pt_BR.fl_str_mv |
Leptospirosis Nitric Oxide Acute renal failure Pulmonary Haemorrhage |
| dc.subject.decs.pt_BR.fl_str_mv |
Adolescente Adulto Idoso Marcadores Biológicos Brasil Feminino Febre Humanos Icterícia Leptospirose Masculino Meia-Idade Óxido Nítrico Insuficiência Respiratória Choque |
| description |
Este trabalho foi financiado por doações da FINEP / PRONEX, Fundação Oswaldo Cruz, Conselho Nacional de Pesquisa, EUA National Institutes of Health e Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
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2006 |
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2006 |
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2011-08-08T13:58:43Z |
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2011-08-08T13:58:43Z |
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info:eu-repo/semantics/article |
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article |
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MACIEL, E. A. P. et al. High serum nitric oxide levels in patients with severe leptospirosis. Acta Tropica, v.100, n.3, p.256–260, dez. 2006. |
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0001-706X |
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MACIEL, E. A. P. et al. High serum nitric oxide levels in patients with severe leptospirosis. Acta Tropica, v.100, n.3, p.256–260, dez. 2006. 0001-706X |
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