The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Sousa, Taís Nóbrega de
Data de Publicação: 2014
Outros Autores: Kano, Flora Satiko, Brito, Cristiana Ferreira Alves de, Carvalho, Luzia Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9582
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, Brasil
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spelling Sousa, Taís Nóbrega deKano, Flora SatikoBrito, Cristiana Ferreira Alves deCarvalho, Luzia Helena2015-03-02T17:30:52Z2015-03-02T17:30:52Z2014SOUSA, Taís Nóbrega de et al . The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon. Mem. Inst. Oswaldo Cruz, v. 109, n. 5, pp. 608-617, 2014.0074-0276https://www.arca.fiocruz.br/handle/icict/958210.1590/0074-0276130592.engFundação Oswaldo CruzThe Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, BrasilPlasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.malariaPlasmodium vivaxDuffy binding proteinnaturally acquired antibodiesgenetic variabilityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9582/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_122.pdf2014_122.pdfapplication/pdf663626https://www.arca.fiocruz.br/bitstream/icict/9582/2/2014_122.pdf7afde180dcee5a1505fac1672960c98dMD52TEXT2014_122.pdf.txt2014_122.pdf.txtExtracted texttext/plain58320https://www.arca.fiocruz.br/bitstream/icict/9582/3/2014_122.pdf.txtca1e1facfe89da7b29b659497bf9119cMD53icict/95822019-06-19 10:07:34.258oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:07:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
spellingShingle The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
Sousa, Taís Nóbrega de
malaria
Plasmodium vivax
Duffy binding protein
naturally acquired antibodies
genetic variability
title_short The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_full The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_fullStr The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_full_unstemmed The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
title_sort The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
author Sousa, Taís Nóbrega de
author_facet Sousa, Taís Nóbrega de
Kano, Flora Satiko
Brito, Cristiana Ferreira Alves de
Carvalho, Luzia Helena
author_role author
author2 Kano, Flora Satiko
Brito, Cristiana Ferreira Alves de
Carvalho, Luzia Helena
author2_role author
author
author
dc.contributor.author.fl_str_mv Sousa, Taís Nóbrega de
Kano, Flora Satiko
Brito, Cristiana Ferreira Alves de
Carvalho, Luzia Helena
dc.subject.en.pt_BR.fl_str_mv malaria
Plasmodium vivax
Duffy binding protein
naturally acquired antibodies
genetic variability
topic malaria
Plasmodium vivax
Duffy binding protein
naturally acquired antibodies
genetic variability
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratorio de Malária. Belo Horizonte, MG, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-03-02T17:30:52Z
dc.date.available.fl_str_mv 2015-03-02T17:30:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUSA, Taís Nóbrega de et al . The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon. Mem. Inst. Oswaldo Cruz, v. 109, n. 5, pp. 608-617, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9582
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-0276130592.
identifier_str_mv SOUSA, Taís Nóbrega de et al . The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon. Mem. Inst. Oswaldo Cruz, v. 109, n. 5, pp. 608-617, 2014.
0074-0276
10.1590/0074-0276130592.
url https://www.arca.fiocruz.br/handle/icict/9582
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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