Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals

Detalhes bibliográficos
Autor(a) principal: Cardoso, Luciana Santos
Data de Publicação: 2011
Outros Autores: Oliveira, Sergio Costa, Souza, Ribson da Paixão de, Góes, Alfredo Miranda de, Oliveira, Ricardo Riccio, Alcântara, L. M, Almeida, M. C, Carvalho Filho, Edgar Marcelino, Araujo, Maria Ilma Andrade Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27362
Resumo: Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Cardoso, Luciana SantosOliveira, Sergio CostaSouza, Ribson da Paixão deGóes, Alfredo Miranda deOliveira, Ricardo RiccioAlcântara, L. MAlmeida, M. CCarvalho Filho, Edgar MarcelinoAraujo, Maria Ilma Andrade Santos2018-07-09T13:38:34Z2018-07-09T13:38:34Z2011CARDOSO, L.C. et al. Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals. Drug Development Research, v. 72, p. 538–548, 2011.0272-4391https://www.arca.fiocruz.br/handle/icict/27362Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Brazilian National Research Council (CNPq).Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciencias da Vida. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador Bahia, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador Bahia, BrasilSchistosoma mansoni infection is associated with a low prevalence of asthma and a less severe form of the disease. The mechanisms underlying this association may include the production of regulatory cells and cytokines. The aim of this study was to evaluate the immune response induced by the S. mansoni antigens, Sm22.6, PIII, and Sm29 and their ability to suppress allergen-specific IL-5 production by peripheral blood mononuclear cells (PBMC) from asthmatic individuals. PBMCs were stimulated in vitro with S. mansoni antigens in the presence or absence of antigen-1 of the mite Dermatophagoides pteronyssinus (Der p1). Cytokines were measured in PBMC supernatants by enzyme-linked immunosorbent assay (ELISA), and the phenotype of cells producing IL-10 was assessed using flow cytometry. High production of S. mansoni antigen-specific IL-10 was observed not only in cells of S. mansoni-infected individuals, but also in cells of noninfected asthmatic individuals. In the former group, the main cellular sources of IL-10 were CD41 CD251, and CD141 cells. The levels of IFN-g, IL-5, and IL-13 in the noninfected asthmatic group were 100 pg/ml in response to the antigens. Moreover, when S. mansoni antigens were added to cultures stimulated with Der p1, levels of IL-10 were increased (Der p152347118; Der p11Sm22.6511897595; Derp11PIII57997331; Derp11Sm2956527288 pg/ ml) with reduced levels of IL-5 (Der p152867219; Der p11Sm22.65937153; Derp11 PIII51327188; Derp11Sm29596786 pg/ml). The S. mansoni antigens evaluated in the present study induced the production of the regulatory cytokine IL-10 and down-modulated the Th2 immune response that participates in the pathology of asthma. 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dc.title.pt_BR.fl_str_mv Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals
title Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals
spellingShingle Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals
Cardoso, Luciana Santos
Asma
Antígenos de Schistosoma mansoni
interleucina-10
Asthma
Schistosoma mansoni antigens
Interleukin-10
title_short Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals
title_full Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals
title_fullStr Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals
title_full_unstemmed Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals
title_sort Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals
author Cardoso, Luciana Santos
author_facet Cardoso, Luciana Santos
Oliveira, Sergio Costa
Souza, Ribson da Paixão de
Góes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Alcântara, L. M
Almeida, M. C
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
author_role author
author2 Oliveira, Sergio Costa
Souza, Ribson da Paixão de
Góes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Alcântara, L. M
Almeida, M. C
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Luciana Santos
Oliveira, Sergio Costa
Souza, Ribson da Paixão de
Góes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Alcântara, L. M
Almeida, M. C
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
dc.subject.other.pt_BR.fl_str_mv Asma
Antígenos de Schistosoma mansoni
interleucina-10
topic Asma
Antígenos de Schistosoma mansoni
interleucina-10
Asthma
Schistosoma mansoni antigens
Interleukin-10
dc.subject.en.pt_BR.fl_str_mv Asthma
Schistosoma mansoni antigens
Interleukin-10
description Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2018-07-09T13:38:34Z
dc.date.available.fl_str_mv 2018-07-09T13:38:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARDOSO, L.C. et al. Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals. Drug Development Research, v. 72, p. 538–548, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27362
dc.identifier.issn.pt_BR.fl_str_mv 0272-4391
identifier_str_mv CARDOSO, L.C. et al. Schistosoma mansoni Antigens Modulate Allergic Response In Vitro in Cells of Asthmatic Individuals. Drug Development Research, v. 72, p. 538–548, 2011.
0272-4391
url https://www.arca.fiocruz.br/handle/icict/27362
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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