Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis

Detalhes bibliográficos
Autor(a) principal: Gomez, Daniel Esteban
Data de Publicação: 1999
Outros Autores: Lorenzo, Mariana S. de, Alonso, Daniel F., Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33489
Resumo: Antorchas Foundation (Buenos Aires) awarded to Daniel E. Gomez and Zilton A. Andrade, and by Pronex (Brazil)
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spelling Gomez, Daniel EstebanLorenzo, Mariana S. deAlonso, Daniel F.Andrade, Zilton de Araújo2019-06-13T13:16:51Z2019-06-13T13:16:51Z1999GOMEZ, Daniel Esteban et al. Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis. American Journal of Tropical Medicine and Hygiene, v. 61, n. 1, p. 9-13, 1999.0002-9637https://www.arca.fiocruz.br/handle/icict/3348910.4269/ajtmh.1999.61.9Antorchas Foundation (Buenos Aires) awarded to Daniel E. Gomez and Zilton A. Andrade, and by Pronex (Brazil)2020-01-06Quilmes National University. Laboratory of Molecular Oncology. Department of Science and Technology. Buenos Aires, Argentina.Quilmes National University. Laboratory of Molecular Oncology. Department of Science and Technology. Buenos Aires, Argentina.Quilmes National University. Laboratory of Molecular Oncology. Department of Science and Technology. Buenos Aires, Argentina.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Focal extracellular matrix degradation morphologically identified in human portal pipestem fibrosis due to Schistosoma mansoni did not express immunohistochemical reactivity for metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2). However, when active schistosomal periovular granulomas were present, a strong reactivity for MMP-1, MMP-2, TIMP-1, and TIMP-2 was observed. No reactivity was ever observed for MMP-9. However, the positive pattern of immunohistochemical expression was not seen in old fibrotic periovular granulomas, which were sometimes situated in other areas of the same microscopic section. Positive staining for MMPs and TIMPs was observed at the same time in hepatocytes and within the apical portion of bile duct epithelium. These findings are consistent with the concept that matrix degradation in recent and old fibroses, in addition to differing at the ultrastructural level, also differs in immunohistochemical expression of metalloproteinases and their inhibitors.engAmerican Society of Tropical Medicine and HygieneSchistosoma MansoniMetaloproteinasesFibroseMatriz extracelularSchistosoma MansoniMetalloproteasesFibrosisExtracellular MatrixExpression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33489/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALZilton A.A. Expression Metall... American Journal 1999.PDFZilton A.A. Expression Metall... American Journal 1999.PDFapplication/pdf6088428https://www.arca.fiocruz.br/bitstream/icict/33489/2/Zilton%20A.A.%20%20Expression%20Metall...%20American%20Journal%201999.PDFf3bee6df8ca8076b45a0dce8e2339dc8MD52TEXTZilton A.A. Expression Metall... American Journal 1999.PDF.txtZilton A.A. Expression Metall... 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dc.title.pt_BR.fl_str_mv Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis
title Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis
spellingShingle Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis
Gomez, Daniel Esteban
Schistosoma Mansoni
Metaloproteinases
Fibrose
Matriz extracelular
Schistosoma Mansoni
Metalloproteases
Fibrosis
Extracellular Matrix
title_short Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis
title_full Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis
title_fullStr Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis
title_full_unstemmed Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis
title_sort Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis
author Gomez, Daniel Esteban
author_facet Gomez, Daniel Esteban
Lorenzo, Mariana S. de
Alonso, Daniel F.
Andrade, Zilton de Araújo
author_role author
author2 Lorenzo, Mariana S. de
Alonso, Daniel F.
Andrade, Zilton de Araújo
author2_role author
author
author
dc.contributor.author.fl_str_mv Gomez, Daniel Esteban
Lorenzo, Mariana S. de
Alonso, Daniel F.
Andrade, Zilton de Araújo
dc.subject.other.pt_BR.fl_str_mv Schistosoma Mansoni
Metaloproteinases
Fibrose
Matriz extracelular
topic Schistosoma Mansoni
Metaloproteinases
Fibrose
Matriz extracelular
Schistosoma Mansoni
Metalloproteases
Fibrosis
Extracellular Matrix
dc.subject.en.pt_BR.fl_str_mv Schistosoma Mansoni
Metalloproteases
Fibrosis
Extracellular Matrix
description Antorchas Foundation (Buenos Aires) awarded to Daniel E. Gomez and Zilton A. Andrade, and by Pronex (Brazil)
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2019-06-13T13:16:51Z
dc.date.available.fl_str_mv 2019-06-13T13:16:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMEZ, Daniel Esteban et al. Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis. American Journal of Tropical Medicine and Hygiene, v. 61, n. 1, p. 9-13, 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33489
dc.identifier.issn.pt_BR.fl_str_mv 0002-9637
dc.identifier.doi.pt_BR.fl_str_mv 10.4269/ajtmh.1999.61.9
identifier_str_mv GOMEZ, Daniel Esteban et al. Expression of Metalloproteinases (MMP-1, MMP-2, and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in Schistosomal portal fibrosis. American Journal of Tropical Medicine and Hygiene, v. 61, n. 1, p. 9-13, 1999.
0002-9637
10.4269/ajtmh.1999.61.9
url https://www.arca.fiocruz.br/handle/icict/33489
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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