In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1996 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7452 |
Resumo: | Universidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / LAboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil |
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Barral Netto, ManoelVon Sohsten, R. LTeixeira, MdosSantos, Washington Luis ConradoPompeu, Margarida Maria de LimaMoreira, R. AOliveira, J. TCavada, Benildo SousaFalcoff, EBarral, Aldina Maria Prado2014-03-26T16:41:14Z2014-03-26T16:41:14Z1996BARRAL-NETTO, M. et al. In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis. Acta Tropica, v. 60, n. 4, p. 237-250 237, 1996.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/7452engElsevier Science B.VIn vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / LAboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, BrasilUniversidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamentos de Patologia & Bioquimica. Fortaleza, CE, Brasillnstitut Curie. Unitk INSERM. PAris, FranceUniversidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilIn vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-gamma (IFN-gamma) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-gamma production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-gamma administration (although IFN-gamma preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-gamma neutralization with anti-IFN-gamma monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-gamma.LeishmaniasisLeishmaniaTegumentary leishmaniasisExperimental leishmaniasisCanavalia brasiliensisInterferon-yAnimaisFemininoInterferon gama/biossínteseLectinas/uso terapêuticoLeishmania mexicanaLeishmaniose Cutânea/terapiaInterferon gama/farmacocinéticaLeishmaniose Cutânea/imunologiaLeishmaniose Cutânea/parasitologiaMacrófagos Peritoneais/efeitos de drogasMacrófagos Peritoneais/parasitologiaCamundongosCamundongos Endogâmicos BALB CRatosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarral-Netto M In vivo protective effect of the lectin....pdfBarral-Netto M In vivo protective effect of the lectin....pdfapplication/pdf979575https://www.arca.fiocruz.br/bitstream/icict/7452/1/Barral-Netto%20M%20In%20vivo%20protective%20effect%20of%20the%20lectin....pdfdfb8ac628ceaf8c94cb72e73fbaa01d7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7452/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBarral-Netto M In vivo protective effect of the lectin....pdf.txtBarral-Netto M In vivo protective effect of the lectin....pdf.txtExtracted texttext/plain39193https://www.arca.fiocruz.br/bitstream/icict/7452/5/Barral-Netto%20M%20In%20vivo%20protective%20effect%20of%20the%20lectin....pdf.txta2c82d52dabd87eef66b4d35d93d4aeaMD55THUMBNAILBarral-Netto M In vivo protective effect of the lectin....pdf.jpgBarral-Netto M In vivo protective effect of the lectin....pdf.jpgGenerated Thumbnailimage/jpeg2312https://www.arca.fiocruz.br/bitstream/icict/7452/4/Barral-Netto%20M%20In%20vivo%20protective%20effect%20of%20the%20lectin....pdf.jpgb3bbaac09454e640df268525f2fd532eMD54icict/74522023-03-15 14:33:12.191oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| title |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| spellingShingle |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis Barral Netto, Manoel Leishmaniasis Leishmania Tegumentary leishmaniasis Experimental leishmaniasis Canavalia brasiliensis Interferon-y Animais Feminino Interferon gama/biossíntese Lectinas/uso terapêutico Leishmania mexicana Leishmaniose Cutânea/terapia Interferon gama/farmacocinética Leishmaniose Cutânea/imunologia Leishmaniose Cutânea/parasitologia Macrófagos Peritoneais/efeitos de drogas Macrófagos Peritoneais/parasitologia Camundongos Camundongos Endogâmicos BALB C Ratos |
| title_short |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| title_full |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| title_fullStr |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| title_full_unstemmed |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| title_sort |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| author |
Barral Netto, Manoel |
| author_facet |
Barral Netto, Manoel Von Sohsten, R. L Teixeira, M dosSantos, Washington Luis Conrado Pompeu, Margarida Maria de Lima Moreira, R. A Oliveira, J. T Cavada, Benildo Sousa Falcoff, E Barral, Aldina Maria Prado |
| author_role |
author |
| author2 |
Von Sohsten, R. L Teixeira, M dosSantos, Washington Luis Conrado Pompeu, Margarida Maria de Lima Moreira, R. A Oliveira, J. T Cavada, Benildo Sousa Falcoff, E Barral, Aldina Maria Prado |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barral Netto, Manoel Von Sohsten, R. L Teixeira, M dosSantos, Washington Luis Conrado Pompeu, Margarida Maria de Lima Moreira, R. A Oliveira, J. T Cavada, Benildo Sousa Falcoff, E Barral, Aldina Maria Prado |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis Leishmania Tegumentary leishmaniasis Experimental leishmaniasis Canavalia brasiliensis Interferon-y Animais Feminino |
| topic |
Leishmaniasis Leishmania Tegumentary leishmaniasis Experimental leishmaniasis Canavalia brasiliensis Interferon-y Animais Feminino Interferon gama/biossíntese Lectinas/uso terapêutico Leishmania mexicana Leishmaniose Cutânea/terapia Interferon gama/farmacocinética Leishmaniose Cutânea/imunologia Leishmaniose Cutânea/parasitologia Macrófagos Peritoneais/efeitos de drogas Macrófagos Peritoneais/parasitologia Camundongos Camundongos Endogâmicos BALB C Ratos |
| dc.subject.decs.pt_BR.fl_str_mv |
Interferon gama/biossíntese Lectinas/uso terapêutico Leishmania mexicana Leishmaniose Cutânea/terapia Interferon gama/farmacocinética Leishmaniose Cutânea/imunologia Leishmaniose Cutânea/parasitologia Macrófagos Peritoneais/efeitos de drogas Macrófagos Peritoneais/parasitologia Camundongos Camundongos Endogâmicos BALB C Ratos |
| description |
Universidade Federal da Bahia. Hospital Univ. Prof. Edgard Santos. Serviço de lmunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / LAboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil |
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1996 |
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1996 |
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2014-03-26T16:41:14Z |
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2014-03-26T16:41:14Z |
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BARRAL-NETTO, M. et al. In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis. Acta Tropica, v. 60, n. 4, p. 237-250 237, 1996. |
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https://www.arca.fiocruz.br/handle/icict/7452 |
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0001-706X |
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BARRAL-NETTO, M. et al. In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis. Acta Tropica, v. 60, n. 4, p. 237-250 237, 1996. 0001-706X |
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