The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18787 |
Resumo: | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil |
| id |
CRUZ_b0c69a0be59c1f40201337c6f5017980 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/18787 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Vidal, Manuela Torres AndionLourenço, Sílvia VanessaSoares, Fernando AugustoGurgel, Clarissa AraújoStudart, Eduardo José BittencourtValverde, Ludmila de FaroAraújo, Iguaracyra Barreto de OliveiraRamos, Eduardo Antônio GonçalvesXavier, Flávia Caló de AquinoSantos, Jean Nunes dos2017-05-08T17:26:00Z2017-05-08T17:26:00Z2016VIDAL, M. T. A. et al. The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration. Tumor Biology, v. 37, p. 9587–9601, 2016.1010-4283https://www.arca.fiocruz.br/handle/icict/1878710.1007/s13277-016-4841-4engSpringer VerlagTumores das glândulas salivaresHedgehogproteinsSTAT fatores de transcriçãoComponente complexo de manutenção do minicromossoma 3Salivary gland tumorsHedgehogproteinsSTAT transcription factorsMinichromosomemaintenance complex component 3TumoresGlândulas salivaresProteinas HedhehogFatores de transcriçãoComponente 3 do complexo de manutenção do minicromossomaThe sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltrationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilA.C. Camargo Cancer Center. São Paulo, SP, BrasilA.C. Camargo Cancer Center. São Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. School of Medicine. Department of Pathology and Forensic Medicine. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Department of Pathology and Forensic Medicine. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil / Universidade Federal da Bahia. Laboratório de Patologia Cirúrgica. Salvador, BA, BrasilThe pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC), and adenoid cystic carcinoma (ACC) are common tumors arising from salivary glands whose histopathology is heterogeneous. The sonic hedgehog signaling pathway (Hh) and signal transducer and activator of transcription 3 (STAT3) play important roles in cell proliferation, favoring tumor growth. The aim of this investigation was to study components of the Hh pathway, as well as STAT3 in salivary gland neoplasms in an attempt to add information about the biological characteristics of these neoplasms. We used 9 cases of PA, 17 cases of ACC, and 20 cases of MEC. Using immunohistochemistry, SHH, GLI1, SUFU, HHIP, and STAT3 were investigated. For comparative purposes, MCM3 (cellular proliferation marker) was also included. In PA, there was high expression of cytoplasmic SHH and SUFU and low expression of STAT3 and MCM3. In the ACC, there was high expression of GLI1, HHIP, and STAT3 and low expression of SHH, SUFU, and MCM3. In the MEC, we observed high expression of SHH, GLI1, SUFU, and HHIP and low expression of STAT3 and MCM3. There was a statistically significant difference between SHH (p = 0.0064), STAT3 (p = 0.0003), and MCM3 (p = 0.0257) when all tumors were compared and a higher expression in parenchyma for all tumors when stroma and parenchyma were compared (p < 0.05). These findings suggests a possible role of Hh pathway in the development and maintenance of the cytoarchitectural pattern of PA, ACC, and MEC, as well as the participation of STAT3 in the development of ACC, irrespective perineural infiltration.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18787/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVidal MTA The sonic hedgehog....pdfVidal MTA The sonic hedgehog....pdfapplication/pdf4649809https://www.arca.fiocruz.br/bitstream/icict/18787/2/Vidal%20MTA%20The%20sonic%20hedgehog....pdfdeaddde6fc8cac4da93e0aea7eb35833MD52TEXTVidal MTA The sonic hedgehog....pdf.txtVidal MTA The sonic hedgehog....pdf.txtExtracted texttext/plain46053https://www.arca.fiocruz.br/bitstream/icict/18787/3/Vidal%20MTA%20The%20sonic%20hedgehog....pdf.txtd6f553c319ad5199b369e182c7229bd3MD53icict/187872023-03-15 14:34:09.629oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration |
| title |
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration |
| spellingShingle |
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration Vidal, Manuela Torres Andion Tumores das glândulas salivares Hedgehogproteins STAT fatores de transcrição Componente complexo de manutenção do minicromossoma 3 Salivary gland tumors Hedgehogproteins STAT transcription factors Minichromosomemaintenance complex component 3 Tumores Glândulas salivares Proteinas Hedhehog Fatores de transcrição Componente 3 do complexo de manutenção do minicromossoma |
| title_short |
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration |
| title_full |
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration |
| title_fullStr |
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration |
| title_full_unstemmed |
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration |
| title_sort |
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration |
| author |
Vidal, Manuela Torres Andion |
| author_facet |
Vidal, Manuela Torres Andion Lourenço, Sílvia Vanessa Soares, Fernando Augusto Gurgel, Clarissa Araújo Studart, Eduardo José Bittencourt Valverde, Ludmila de Faro Araújo, Iguaracyra Barreto de Oliveira Ramos, Eduardo Antônio Gonçalves Xavier, Flávia Caló de Aquino Santos, Jean Nunes dos |
| author_role |
author |
| author2 |
Lourenço, Sílvia Vanessa Soares, Fernando Augusto Gurgel, Clarissa Araújo Studart, Eduardo José Bittencourt Valverde, Ludmila de Faro Araújo, Iguaracyra Barreto de Oliveira Ramos, Eduardo Antônio Gonçalves Xavier, Flávia Caló de Aquino Santos, Jean Nunes dos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vidal, Manuela Torres Andion Lourenço, Sílvia Vanessa Soares, Fernando Augusto Gurgel, Clarissa Araújo Studart, Eduardo José Bittencourt Valverde, Ludmila de Faro Araújo, Iguaracyra Barreto de Oliveira Ramos, Eduardo Antônio Gonçalves Xavier, Flávia Caló de Aquino Santos, Jean Nunes dos |
| dc.subject.other.pt_BR.fl_str_mv |
Tumores das glândulas salivares Hedgehogproteins STAT fatores de transcrição Componente complexo de manutenção do minicromossoma 3 |
| topic |
Tumores das glândulas salivares Hedgehogproteins STAT fatores de transcrição Componente complexo de manutenção do minicromossoma 3 Salivary gland tumors Hedgehogproteins STAT transcription factors Minichromosomemaintenance complex component 3 Tumores Glândulas salivares Proteinas Hedhehog Fatores de transcrição Componente 3 do complexo de manutenção do minicromossoma |
| dc.subject.en.pt_BR.fl_str_mv |
Salivary gland tumors Hedgehogproteins STAT transcription factors Minichromosomemaintenance complex component 3 |
| dc.subject.decs.pt_BR.fl_str_mv |
Tumores Glândulas salivares Proteinas Hedhehog Fatores de transcrição Componente 3 do complexo de manutenção do minicromossoma |
| description |
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil |
| publishDate |
2016 |
| dc.date.issued.fl_str_mv |
2016 |
| dc.date.accessioned.fl_str_mv |
2017-05-08T17:26:00Z |
| dc.date.available.fl_str_mv |
2017-05-08T17:26:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
VIDAL, M. T. A. et al. The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration. Tumor Biology, v. 37, p. 9587–9601, 2016. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18787 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1010-4283 |
| dc.identifier.doi.none.fl_str_mv |
10.1007/s13277-016-4841-4 |
| identifier_str_mv |
VIDAL, M. T. A. et al. The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration. Tumor Biology, v. 37, p. 9587–9601, 2016. 1010-4283 10.1007/s13277-016-4841-4 |
| url |
https://www.arca.fiocruz.br/handle/icict/18787 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Springer Verlag |
| publisher.none.fl_str_mv |
Springer Verlag |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/18787/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/18787/2/Vidal%20MTA%20The%20sonic%20hedgehog....pdf https://www.arca.fiocruz.br/bitstream/icict/18787/3/Vidal%20MTA%20The%20sonic%20hedgehog....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 deaddde6fc8cac4da93e0aea7eb35833 d6f553c319ad5199b369e182c7229bd3 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324755708772352 |