Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil

Detalhes bibliográficos
Autor(a) principal: Delatorre, Edson
Data de Publicação: 2015
Outros Autores: Castro, Carlos A. Velasco de, Pilotto, Jose H., Fernandez, José Carlos Couto, Bello, Gonzalo, Morgado, Mariza G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12361
Resumo: 2016-11-30
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spelling Delatorre, EdsonCastro, Carlos A. Velasco dePilotto, Jose H.Fernandez, José Carlos CoutoBello, GonzaloMorgado, Mariza G.2015-12-08T14:38:22Z2015DELATORRE, Edson; et al. Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil. AIDS Research and Human Retroviruses, v.31, n.12, Nov. 2015.0889-2229https://www.arca.fiocruz.br/handle/icict/1236110.1089/aid.2015.01831931-8405engMary Ann LiebertHIV-1BrasilRio de JaneiroHIV-1BrazilHIV-1 CRF02_AG LineagesShort Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2016-11-30Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Patologia Clínica. Laboratório de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.HIV-1 CRF02_AG is responsible for at least 8% of the HIV-1 infections worldwide and is distributed mainly in West Africa. CRF02_AG has recently been reported in countries where it is not native, including Brazil. In a previous study including 10 CRF02_AG Brazilian samples, we found at least four independent introductions and two autochthonous transmission networks of this clade in Brazil. As more CRF02_AG samples have been identified in Brazil, we performed a new phylogeographic analysis using a larger dataset than before. A total of 20 Brazilian (18 from Rio de Janeiro and two from Sa˜o Paulo) and 1,485 African HIV-1 CRF02_AG pol sequences were analyzed using maximum likelihood (ML). The ML tree showed that the Brazilian sequences were distributed in five different lineages. The Bayesian phylogeographic analysis of the Brazilian and their most closely related African sequences (n = 212) placed the origin of all Brazilian lineages in West Africa, probably Ghana, Senegal, and Nigeria. Two monophyletic clades were identified, comprising only sequences from Rio de Janeiro, and their date of origin was estimated at around 1985 (95% highest posterior density: 1979–1992). These results support the existence of at least five independent introductions of the CRF02_AG lineage from West Africa into Brazil and further indicate that at least two of these lineages have been locally disseminated in the Rio de Janeiro state over the past 30 years.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALedson_delatorre_etal_IOC_2015.pdfedson_delatorre_etal_IOC_2015.pdfapplication/pdf745304https://www.arca.fiocruz.br/bitstream/icict/12361/2/edson_delatorre_etal_IOC_2015.pdfc9a374dca91e38e3b405882c3f116ac4MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12361/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTedson_delatorre_etal_IOC_2015.pdf.txtedson_delatorre_etal_IOC_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
title Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
spellingShingle Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
Delatorre, Edson
HIV-1
Brasil
Rio de Janeiro
HIV-1
Brazil
HIV-1 CRF02_AG Lineages
title_short Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
title_full Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
title_fullStr Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
title_full_unstemmed Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
title_sort Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
author Delatorre, Edson
author_facet Delatorre, Edson
Castro, Carlos A. Velasco de
Pilotto, Jose H.
Fernandez, José Carlos Couto
Bello, Gonzalo
Morgado, Mariza G.
author_role author
author2 Castro, Carlos A. Velasco de
Pilotto, Jose H.
Fernandez, José Carlos Couto
Bello, Gonzalo
Morgado, Mariza G.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Delatorre, Edson
Castro, Carlos A. Velasco de
Pilotto, Jose H.
Fernandez, José Carlos Couto
Bello, Gonzalo
Morgado, Mariza G.
dc.subject.other.pt_BR.fl_str_mv HIV-1
Brasil
Rio de Janeiro
topic HIV-1
Brasil
Rio de Janeiro
HIV-1
Brazil
HIV-1 CRF02_AG Lineages
dc.subject.en.pt_BR.fl_str_mv HIV-1
Brazil
HIV-1 CRF02_AG Lineages
description 2016-11-30
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-12-08T14:38:22Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DELATORRE, Edson; et al. Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil. AIDS Research and Human Retroviruses, v.31, n.12, Nov. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12361
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.doi.none.fl_str_mv 10.1089/aid.2015.0183
dc.identifier.eissn.none.fl_str_mv 1931-8405
identifier_str_mv DELATORRE, Edson; et al. Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil. AIDS Research and Human Retroviruses, v.31, n.12, Nov. 2015.
0889-2229
10.1089/aid.2015.0183
1931-8405
url https://www.arca.fiocruz.br/handle/icict/12361
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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