Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection

Detalhes bibliográficos
Autor(a) principal: Cruz, Maria da Fátima Ferreira
Data de Publicação: 1992
Outros Autores: Passo, Roberto Machado, Fortier, Bernardo, Ribeiro, Cláudio Tadeu Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37400
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO para Pesquisa e Treinamento em Doenças Parasitárias. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
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spelling Cruz, Maria da Fátima FerreiraPasso, Roberto MachadoFortier, BernardoRibeiro, Cláudio Tadeu Daniel2019-11-26T17:25:01Z2019-11-26T17:25:01Z1992CRUZ, Maria de Fátima Ferreira da et al. Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 3, p. 187-192, 1992.0074-0206https://www.arca.fiocruz.br/handle/icict/3740010.1590/S0074-027619920007000311678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzPlasmodium falciparumPlasmodium vivaxDiagnósticoAntígeno plamodialAnticorposEnsaio imunoenzimáticoPlasmodium falciparumPlasmodium vivaxDiagnosisPlamodial antigenMonocionalAntibodyImmunoenzymatic assayDevelopment of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO para Pesquisa e Treinamento em Doenças Parasitárias. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO para Pesquisa e Treinamento em Doenças Parasitárias. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Unite Inserum U 42. Villeneuve d'Aseq. France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO para Pesquisa e Treinamento em Doenças Parasitárias. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.The WHO criterion of defering any donation of blood by a confirmed case of malaria for three years after cessation of therapy can not be applied in areas where malaria in endemic. For this reason we developed an immunoenzymatic assay for the detection of plasmodial antigens for blood screening in malararial endemic areas. So, we tested sera from 191 individuals. Among patients with active disease 100% of the cases of Plasmodium falciparum or mixed infections and 91.7% of those with P. vivax were positive for the presence of plasmodial antigens. The lower parasitaemia detected was 0.0003% for P. vivax malária. When the frequency of positive circulating malarial antigens was evaluated among asymptomatic and symptomatic individuals with negative TBS, positive results were found in respectively 38.7% and 17.7% of the individuals studied in the 30 days after confirmed malaria attack. Data provide by these assays have shown that ELISA seemed to be more sensitive than parasitological examination for malaria diagnosis. This test by virtue of its high sensivity and the facilities in processing a large number of specimens, can prove to be useful in endemic areas for the recognition of asymptomatic malaria and screening of blood donors.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37400/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariaFFCruz_ClaudioRibeiro_etal_IOC_1992.pdfMariaFFCruz_ClaudioRibeiro_etal_IOC_1992.pdfapplication/pdf350868https://www.arca.fiocruz.br/bitstream/icict/37400/2/MariaFFCruz_ClaudioRibeiro_etal_IOC_1992.pdfbb01ba2946b13868506fbd35e02824f9MD52TEXTMariaFFCruz_ClaudioRibeiro_etal_IOC_1992.pdf.txtMariaFFCruz_ClaudioRibeiro_etal_IOC_1992.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection
title Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection
spellingShingle Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection
Cruz, Maria da Fátima Ferreira
Plasmodium falciparum
Plasmodium vivax
Diagnóstico
Antígeno plamodial
Anticorpos
Ensaio imunoenzimático
Plasmodium falciparum
Plasmodium vivax
Diagnosis
Plamodial antigen
Monocional
Antibody
Immunoenzymatic assay
title_short Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection
title_full Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection
title_fullStr Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection
title_full_unstemmed Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection
title_sort Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection
author Cruz, Maria da Fátima Ferreira
author_facet Cruz, Maria da Fátima Ferreira
Passo, Roberto Machado
Fortier, Bernardo
Ribeiro, Cláudio Tadeu Daniel
author_role author
author2 Passo, Roberto Machado
Fortier, Bernardo
Ribeiro, Cláudio Tadeu Daniel
author2_role author
author
author
dc.contributor.author.fl_str_mv Cruz, Maria da Fátima Ferreira
Passo, Roberto Machado
Fortier, Bernardo
Ribeiro, Cláudio Tadeu Daniel
dc.subject.other.pt_BR.fl_str_mv Plasmodium falciparum
Plasmodium vivax
Diagnóstico
Antígeno plamodial
Anticorpos
Ensaio imunoenzimático
topic Plasmodium falciparum
Plasmodium vivax
Diagnóstico
Antígeno plamodial
Anticorpos
Ensaio imunoenzimático
Plasmodium falciparum
Plasmodium vivax
Diagnosis
Plamodial antigen
Monocional
Antibody
Immunoenzymatic assay
dc.subject.en.pt_BR.fl_str_mv Plasmodium falciparum
Plasmodium vivax
Diagnosis
Plamodial antigen
Monocional
Antibody
Immunoenzymatic assay
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO para Pesquisa e Treinamento em Doenças Parasitárias. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2019-11-26T17:25:01Z
dc.date.available.fl_str_mv 2019-11-26T17:25:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CRUZ, Maria de Fátima Ferreira da et al. Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 3, p. 187-192, 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37400
dc.identifier.issn.pt_BR.fl_str_mv 0074-0206
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761992000700031
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv CRUZ, Maria de Fátima Ferreira da et al. Development of an immunoenzymatic assay using a monoclonal antibody against a 50-kDa catabolite from the P126 Plasmodium falciparum protein to the diagnosis of malaria infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 3, p. 187-192, 1992.
0074-0206
10.1590/S0074-02761992000700031
1678-8060
url https://www.arca.fiocruz.br/handle/icict/37400
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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