Emergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazon
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45062 |
Resumo: | Oxford University Press (OUP) [University Publisher] Infectious Diseases Society of America [Associate OrganisationOpen Access pathways permitted by this journal's policy are listed below by article version. Click on a pathway for a more detailed view. Published Version [pathway a] NoneCC BYPMC Institutional Repository, Subject Repository, PMC, +1 OA FeeThis pathway has an Open Access fee associated with it OA PublishingThis pathway includes Open Access publishing Embargo - No Embargo |
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Rosa, Patricia S.D`Espindula, Helena R. S.Melo, Ana C. L.Fontes, Amanda N. B.Finardi, Amanda J.Belone, Andréa F. F.Sartori, Beatriz G. C.Pires, Carla A. A.Soares, Cleverson T.Marques, Flávio B.Branco, Francisco J. D.Baptista, Ida M. F. D.Trin, Lázara M.Fachin, Luciana R. V.Xavier, Marilia B.Floriano, Marcos C.Ura, SomeiDiório, Suzana M.Delanina, Wladimir F. B.Moraes, Milton O.Virmond, Marcos C. L.Suffys, Phlilp N.Mira, Marcelo T.2020-12-21T18:45:56Z2020-12-21T18:45:56Z2020ROSA, Patrícia S. et al. Emergence and transmission of drug-/multidrug-resistant Mycobcaterium leprae in a former leprozy colony in the Bazilian Amazon. Clinical Infectious Diseases, v. 70, n. 10, p. 2054-2061, 2020.1058-4838https://www.arca.fiocruz.br/handle/icict/4506210.1093/cid/ciz570Oxford University Press (OUP) [University Publisher] Infectious Diseases Society of America [Associate OrganisationOpen Access pathways permitted by this journal's policy are listed below by article version. Click on a pathway for a more detailed view. Published Version [pathway a] NoneCC BYPMC Institutional Repository, Subject Repository, PMC, +1 OA FeeThis pathway has an Open Access fee associated with it OA PublishingThis pathway includes Open Access publishing Embargo - No EmbargoInstituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pòs-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Centro de Referência Nacional em Dermatologia Sanitária Dona Libânia. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Universidade Federal do Pará. Núcleo de Doenças Tropicais. Belém, PA, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Centro de Referência Nacional em Dermatologia Sanitária Dona Libânia. Fortaleza, CE, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Universidade Federal do Pará. Núcleo de Doenças Tropicais. Belém, PA, Brasil / Universidade do Estado do Pará. Centro de Ciências Biológicas e da Saúde. Belém, PA, Brasil.Universidade Federal de São Paulo. Departamento de Dermatologia. São Paulo, SP, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil.Instituto Lauro de Souza Lima. Divisão de Pesquisa e Educação. Bauru, São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pòs-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Background: Leprosy has been treated with multidrug therapy (MDT) distributed for free across the globe and regarded as highly efficient. However, the impossibility to grow M. leprae in axenic media has historically impaired assessment of M. leprae resistance, a parameter only recently detectable through molecular methods. Methods: A systematic, population-based search for M. leprae resistance in suspected leprosy relapse cases and contacts was performed in Prata Village, an isolated, hyper-endemic former leprosy colony located in the Brazilian Amazon. Results led to an extended active search involving the entire Prata population. Confirmed leprosy cases were investigated for bacterial resistance using a combination of in vivo testing and direct sequencing of resistance genes folP1, rpoB and gyrA. Molecular epidemiology analysis was performed using data from 17 variable number tandem repeats (VNTR). Results: M. leprae was obtained from biopsies of 37 leprosy cases (18 relapses and 19 new); 16 (43.24%) displayed drug-resistance variants. Multi-drug resistance to rifampicin and dapsone was observed in 8 relapses and 4 new cases. Single resistance to rifampicin was detected in one new case. Resistance to dapsone was present in two relapses and one new case. Combined molecular resistance and VNTR data revealed evidence of intra-familial primary transmission of resistant M. leprae. Conclusions: A comprehensive, population-based systematic approach to investigate M. leprae resistance in a unique population revealed an alarming scenario of emergence and transmission of resistant strains. These findings may be used for the development of new strategies for surveillance of drug resistance in other populations.engOxford University PressEmergênciaTransmissãoMycobacterium lepraeFármacoMultiresistenteEx-colônia de HanseníaseAmazônia brasileiraLeprosyMycobacterium lepraeMultidrug resistancePrimary resistanceTransmissionEmergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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Emergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazon |
| title |
Emergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazon |
| spellingShingle |
Emergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazon Rosa, Patricia S. Emergência Transmissão Mycobacterium leprae Fármaco Multiresistente Ex-colônia de Hanseníase Amazônia brasileira Leprosy Mycobacterium leprae Multidrug resistance Primary resistance Transmission |
| title_short |
Emergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazon |
| title_full |
Emergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazon |
| title_fullStr |
Emergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazon |
| title_full_unstemmed |
Emergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazon |
| title_sort |
Emergence and transmission of Drug-/Multidrug-resistant Mycobacterium Leprae in a former leprosy colonyin the Brazilian Amazon |
| author |
Rosa, Patricia S. |
| author_facet |
Rosa, Patricia S. D`Espindula, Helena R. S. Melo, Ana C. L. Fontes, Amanda N. B. Finardi, Amanda J. Belone, Andréa F. F. Sartori, Beatriz G. C. Pires, Carla A. A. Soares, Cleverson T. Marques, Flávio B. Branco, Francisco J. D. Baptista, Ida M. F. D. Trin, Lázara M. Fachin, Luciana R. V. Xavier, Marilia B. Floriano, Marcos C. Ura, Somei Diório, Suzana M. Delanina, Wladimir F. B. Moraes, Milton O. Virmond, Marcos C. L. Suffys, Phlilp N. Mira, Marcelo T. |
| author_role |
author |
| author2 |
D`Espindula, Helena R. S. Melo, Ana C. L. Fontes, Amanda N. B. Finardi, Amanda J. Belone, Andréa F. F. Sartori, Beatriz G. C. Pires, Carla A. A. Soares, Cleverson T. Marques, Flávio B. Branco, Francisco J. D. Baptista, Ida M. F. D. Trin, Lázara M. Fachin, Luciana R. V. Xavier, Marilia B. Floriano, Marcos C. Ura, Somei Diório, Suzana M. Delanina, Wladimir F. B. Moraes, Milton O. Virmond, Marcos C. L. Suffys, Phlilp N. Mira, Marcelo T. |
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author author author author author author author author author author author author author author author author author author author author author author |
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Rosa, Patricia S. D`Espindula, Helena R. S. Melo, Ana C. L. Fontes, Amanda N. B. Finardi, Amanda J. Belone, Andréa F. F. Sartori, Beatriz G. C. Pires, Carla A. A. Soares, Cleverson T. Marques, Flávio B. Branco, Francisco J. D. Baptista, Ida M. F. D. Trin, Lázara M. Fachin, Luciana R. V. Xavier, Marilia B. Floriano, Marcos C. Ura, Somei Diório, Suzana M. Delanina, Wladimir F. B. Moraes, Milton O. Virmond, Marcos C. L. Suffys, Phlilp N. Mira, Marcelo T. |
| dc.subject.other.pt_BR.fl_str_mv |
Emergência Transmissão Mycobacterium leprae Fármaco Multiresistente Ex-colônia de Hanseníase Amazônia brasileira |
| topic |
Emergência Transmissão Mycobacterium leprae Fármaco Multiresistente Ex-colônia de Hanseníase Amazônia brasileira Leprosy Mycobacterium leprae Multidrug resistance Primary resistance Transmission |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy Mycobacterium leprae Multidrug resistance Primary resistance Transmission |
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Oxford University Press (OUP) [University Publisher] Infectious Diseases Society of America [Associate OrganisationOpen Access pathways permitted by this journal's policy are listed below by article version. Click on a pathway for a more detailed view. Published Version [pathway a] NoneCC BYPMC Institutional Repository, Subject Repository, PMC, +1 OA FeeThis pathway has an Open Access fee associated with it OA PublishingThis pathway includes Open Access publishing Embargo - No Embargo |
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2020 |
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2020-12-21T18:45:56Z |
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2020-12-21T18:45:56Z |
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2020 |
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ROSA, Patrícia S. et al. Emergence and transmission of drug-/multidrug-resistant Mycobcaterium leprae in a former leprozy colony in the Bazilian Amazon. Clinical Infectious Diseases, v. 70, n. 10, p. 2054-2061, 2020. |
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https://www.arca.fiocruz.br/handle/icict/45062 |
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1058-4838 |
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10.1093/cid/ciz570 |
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ROSA, Patrícia S. et al. Emergence and transmission of drug-/multidrug-resistant Mycobcaterium leprae in a former leprozy colony in the Bazilian Amazon. Clinical Infectious Diseases, v. 70, n. 10, p. 2054-2061, 2020. 1058-4838 10.1093/cid/ciz570 |
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Oxford University Press |
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