Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection

Detalhes bibliográficos
Autor(a) principal: Couto, Ingrid
Data de Publicação: 2017
Outros Autores: Victoria, Marilu, Veloso, Valdiléa G., Rodrigues, Lorena, Grinsztejn, Beatriz, Lacerda, Marcus, Victoria, Flamir, Perazzo, Hugo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25649
Resumo: Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil.
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spelling Couto, IngridVictoria, MariluVeloso, Valdiléa G.Rodrigues, LorenaGrinsztejn, BeatrizLacerda, MarcusVictoria, FlamirPerazzo, Hugo2018-04-05T18:35:49Z2018-04-05T18:35:49Z2017COUTO, Ingrid et al. Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection. PLOS One, v. 12, n. 3, p. 1-15, 22 March 2017.1932-6203https://www.arca.fiocruz.br/handle/icict/2564910.1371/journal.pone.0174453engPrevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto de Pesquisas Leônidas & Maria Deane. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.The study aimed to evaluate the prevalence and predictor factors for compensated advanced chronic liver disease (c-ACLD) in patients with hepatitis Delta virus (HDV) infection. Methods This cross-sectional study included consecutive HDV-infected patients defined by positive anti-HDV. Patients with hepatitis C coinfection, liver transplantation or presence of conditions that limit liver (LSM) or spleen stiffness measurement (SSM) were excluded. Blood tests, abdominal ultrasound, SSM and LSM by transient elastography (FibroScan®) were performed at the same day. Alcohol consumption was quantified using the AUDIT score and c-ACLD was defined by LSM 15 kPa performed by an experimented operator blinded for clinical and laboratory data. Results 101 patients were eligible and few patients were excluded due to negative anti-HDV (n = 7), hepatitis C coinfection (n = 2), liver transplantation (n = 10) and limitation for LSM or SSM (n = 5). Therefore, 77 patients [61% male, age = 43 (IQR,36–52) years] were included. The prevalence of c-ACLD was 57% (n = 44/77). Patients with c-ACLD had a higher rate of detectable HBV viral load (p = 0.039), higher levels of transaminases, GGT, alkaline phosphatases, total bilirubin and INR (p<0.001 for all), as well as lower platelet count and albumin levels (p>0.001 for both) compared to those without c-ACLD. Patients with c-ACLD had higher SSM [65.2 (IQR,33.8–75.0) vs 21.8 (16.5–32.0) kPa; p<0.001] and higher splenic volume [475 (IQR,311–746) vs 154 (112–283) cm3 ; p<0.001] compared to those without. Detectable HBV viral load (>10 UI/ml), alkaline phosphatase (per IU/L) and GGT levels (per IU/L) were independently associated with c-ACLD in all multivariate models. Splenic volume [per cm3, OR = 1.01 (95%CI,1.01–1.02);p = 0.002], SSM [per kPa, OR = 1.04 (1.01–1.07); p = 0.012] and splenomegaly [yes vs no,OR = 28.45 (4.42–182.95);p<0.001] were independently associated with c-ACLD. Conclusions: The prevalence of c-ACLD was high in patients with chronic HDV infection in western Amazon basin. HBV viral load, liver enzymes and splenic features can be used to predict severe liver disease in HDV-infected patients.Advanced Chronic Liver Disease (c-ACLD)Hepatitis Delta Virus (HDV) InfectionPatientsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/25649/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALve_Ingrid_Couto_etal_INI_Lapclin_2017.pdfve_Ingrid_Couto_etal_INI_Lapclin_2017.pdfapplication/pdf1842639https://www.arca.fiocruz.br/bitstream/icict/25649/2/ve_Ingrid_Couto_etal_INI_Lapclin_2017.pdfd39cffc2d76c7f0d92c8789f4ce0e2acMD52TEXTve_Ingrid_Couto_etal_INI_Lapclin_2017.pdf.txtve_Ingrid_Couto_etal_INI_Lapclin_2017.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection
title Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection
spellingShingle Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection
Couto, Ingrid
Advanced Chronic Liver Disease (c-ACLD)
Hepatitis Delta Virus (HDV) Infection
Patients
title_short Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection
title_full Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection
title_fullStr Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection
title_full_unstemmed Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection
title_sort Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection
author Couto, Ingrid
author_facet Couto, Ingrid
Victoria, Marilu
Veloso, Valdiléa G.
Rodrigues, Lorena
Grinsztejn, Beatriz
Lacerda, Marcus
Victoria, Flamir
Perazzo, Hugo
author_role author
author2 Victoria, Marilu
Veloso, Valdiléa G.
Rodrigues, Lorena
Grinsztejn, Beatriz
Lacerda, Marcus
Victoria, Flamir
Perazzo, Hugo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Couto, Ingrid
Victoria, Marilu
Veloso, Valdiléa G.
Rodrigues, Lorena
Grinsztejn, Beatriz
Lacerda, Marcus
Victoria, Flamir
Perazzo, Hugo
dc.subject.en.pt_BR.fl_str_mv Advanced Chronic Liver Disease (c-ACLD)
Hepatitis Delta Virus (HDV) Infection
Patients
topic Advanced Chronic Liver Disease (c-ACLD)
Hepatitis Delta Virus (HDV) Infection
Patients
description Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-04-05T18:35:49Z
dc.date.available.fl_str_mv 2018-04-05T18:35:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv COUTO, Ingrid et al. Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection. PLOS One, v. 12, n. 3, p. 1-15, 22 March 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25649
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0174453
identifier_str_mv COUTO, Ingrid et al. Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection. PLOS One, v. 12, n. 3, p. 1-15, 22 March 2017.
1932-6203
10.1371/journal.pone.0174453
url https://www.arca.fiocruz.br/handle/icict/25649
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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