Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses

Detalhes bibliográficos
Autor(a) principal: Geiger, Stefan Michael
Data de Publicação: 2011
Outros Autores: Alexander, Neal Douglas Edward, Fujiwara, Ricardo Toshio, Brooker, Simon, Cundill, Bonnie, Diemert, David Joseph, Oliveira, Rodrigo Corrêa, Bethony, Jeffrey Michael
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8694
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ The George Washington University. Medical Center. Department of Microbiology, Immunology and Tropical Medicine. Washington, D.C., United States of America
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spelling Geiger, Stefan MichaelAlexander, Neal Douglas EdwardFujiwara, Ricardo ToshioBrooker, SimonCundill, BonnieDiemert, David JosephOliveira, Rodrigo CorrêaBethony, Jeffrey Michael2014-10-29T18:27:38Z2014-10-29T18:27:38Z2011GEIGER, Stefan Michael et al. Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses. Plos Neglect Trop D 5(9): e1280, 2011.1932-6203https://www.arca.fiocruz.br/handle/icict/869410.1371/journal.pntd.0001280engPublic Library of ScienceNecator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responsesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ The George Washington University. Medical Center. Department of Microbiology, Immunology and Tropical Medicine. Washington, D.C., United States of AmericaThe George Washington University. Medical Center. Department of Microbiology, Immunology and Tropical Medicine. Washington, D.C., United States of America/ London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases and Department for Epidemiology and Population Health. London, United KingdomUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, BrazilLondon School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases and Department for Epidemiology and Population Health. London, United KingdomLondon School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases and Department for Epidemiology and Population Health. London, United KingdomThe George Washington University. Medical Center. Department of Microbiology, Immunology and Tropical Medicine. Washington, D.C., United States of AmericaFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ The George Washington University. Medical Center. Department of Microbiology, Immunology and Tropical Medicine. Washington, D.C., United States of AmericaBackground: Helminth co-infection in humans is common in tropical regions of the world where transmission of soil-transmitted helminths such as Ascaris lumbricoides, Trichuris trichiura, and the hookworms Necator americanus and Ancylostoma duodenale as well as other helminths such as Schistosoma mansoni often occur simultaneously. Methodology: We investigated whether co-infection with another helminth(s) altered the human immune response to crude antigen extracts from either different stages of N. americanus infection (infective third stage or adult) or different crude antigen extract preparations (adult somatic and adult excretory/secretory). Using these antigens, we compared the cellular and humoral immune responses of individuals mono-infected with hookworm (N. americanus) and individuals co-infected with hookworm and other helminth infections, namely co-infection with either A. lumbricoides, Schistosoma mansoni, or both. Immunological variables were compared between hookworm infection group (mono- versus co-infected) by bootstrap, and principal component analysis (PCA) was used as a data reduction method. Conclusions: Contrary to several animal studies of helminth co-infection, we found that co-infected individuals had a further downmodulated Th1 cytokine response (e.g., reduced INF-γ), accompanied by a significant increase in the hookworm-specific humoral immune response (e.g. higher levels of IgE or IgG4 to crude antigen extracts) compared with mono- infected individuals. Neither of these changes was associated with a reduction of hookworm infection intensity in helminth co-infected individuals. From the standpoint of hookworm vaccine development, these results are relevant; i.e., the specific immune response to hookworm vaccine antigens might be altered by infection with another helminth.ChemokinesCo-infectionsCytokinesHelminth infectionsImmune responseSchistosoma mansoniinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8694/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALNecator americanus and Helminth Co-Infections.pdfNecator americanus and Helminth Co-Infections.pdfapplication/pdf370573https://www.arca.fiocruz.br/bitstream/icict/8694/2/Necator%20americanus%20and%20Helminth%20Co-Infections.pdffb79ab7c69c2db18bb82bd8d6e25b430MD52TEXTNecator americanus and Helminth Co-Infections.pdf.txtNecator americanus and Helminth Co-Infections.pdf.txtExtracted texttext/plain53097https://www.arca.fiocruz.br/bitstream/icict/8694/3/Necator%20americanus%20and%20Helminth%20Co-Infections.pdf.txt7bdf12fb7511487a320660e8bf32aecaMD53icict/86942019-06-19 10:13:46.218oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:13:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
title Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
spellingShingle Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
Geiger, Stefan Michael
Chemokines
Co-infections
Cytokines
Helminth infections
Immune response
Schistosoma mansoni
title_short Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
title_full Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
title_fullStr Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
title_full_unstemmed Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
title_sort Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
author Geiger, Stefan Michael
author_facet Geiger, Stefan Michael
Alexander, Neal Douglas Edward
Fujiwara, Ricardo Toshio
Brooker, Simon
Cundill, Bonnie
Diemert, David Joseph
Oliveira, Rodrigo Corrêa
Bethony, Jeffrey Michael
author_role author
author2 Alexander, Neal Douglas Edward
Fujiwara, Ricardo Toshio
Brooker, Simon
Cundill, Bonnie
Diemert, David Joseph
Oliveira, Rodrigo Corrêa
Bethony, Jeffrey Michael
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Geiger, Stefan Michael
Alexander, Neal Douglas Edward
Fujiwara, Ricardo Toshio
Brooker, Simon
Cundill, Bonnie
Diemert, David Joseph
Oliveira, Rodrigo Corrêa
Bethony, Jeffrey Michael
dc.subject.en.pt_BR.fl_str_mv Chemokines
Co-infections
Cytokines
Helminth infections
Immune response
Schistosoma mansoni
topic Chemokines
Co-infections
Cytokines
Helminth infections
Immune response
Schistosoma mansoni
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ The George Washington University. Medical Center. Department of Microbiology, Immunology and Tropical Medicine. Washington, D.C., United States of America
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-10-29T18:27:38Z
dc.date.available.fl_str_mv 2014-10-29T18:27:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv GEIGER, Stefan Michael et al. Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses. Plos Neglect Trop D 5(9): e1280, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8694
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0001280
identifier_str_mv GEIGER, Stefan Michael et al. Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses. Plos Neglect Trop D 5(9): e1280, 2011.
1932-6203
10.1371/journal.pntd.0001280
url https://www.arca.fiocruz.br/handle/icict/8694
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Public Library of Science
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