Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8125 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil |
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Mascarenhas, Rita Elizabeth MoreiraBrodskyn, Claudia IdaBarbosa, GeisaClarêncio, JorgeAndrade Filho, Antonio de SouzaFigueiroa, FredericoCastro Filho, Bernardo GalvãoGrassi, Maria Fernanda Rios2014-08-04T18:42:15Z2014-08-04T18:42:15Z2006MASCARENHAS, R. E. et al. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clinical and Vaccine Immunology, v. 13, n. 5, p. 547-552, 2006.1556-6811https://www.arca.fiocruz.br/handle/icict/812510.1128/CVI.13.5.547–552.2006engAmerican Society for MicrobiologyPeripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigensinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilNeurology and Neurosurgery Foundation. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilNeurology and Neurosurgery Foundation. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilEvidence indicates that human T-cell lymphotropic virus type 1 (HTLV-1) infection leads to chronic immunosuppression and a greater susceptibility to infectious diseases. Spontaneous in vitro proliferation of peripheral blood mononuclear cells (PBMC) is an important immunological feature of HTLV-1-infected individuals. However, the association between spontaneous proliferation and immunosuppression is not clear. In this study, we evaluated the cellular immune responses of PBMC from 58 asymptomatic HTLV-1-infected individuals with PBMC showing or not showing spontaneous proliferation. Individuals with PBMC that spontaneously proliferated had increased proportions of CD4 T cells expressing CD45RO and dramatically reduced responses to recall antigens. In addition, frequencies of positive responses to recall antigens were also decreased in HTLV-infected individuals without spontaneous proliferation of PBMC. There was a polyclonal expansion of multiple T-cell receptor V families of CD4 T lymphocytes in patients with spontaneous proliferation. We observed that HTLV-1 induced an immunosuppression characterized by a decrease in the stimulation index to a recall antigen, even in individuals who did not present spontaneous proliferation. On the other hand, only patients with PBMC presenting spontaneous proliferation showed polyclonal activation and increased proportion of CD4 T cells expressing CD45RO.Antígenos/imunologiaInfecções por HTLV-I/imunologiaVírus 1 Linfotrópico T Humano/imunologiaTolerância Imunológica/imunologiaLeucócitos Mononucleares/imunologiaSubpopulações de Linfócitos T/imunologiaAdultoAntígenos CD45/biossínteseLinfócitos T CD4-Positivos/citologiaProliferação de CélulasFemininoHumanosMemória ImunológicaLeucócitos Mononucleares/citologiaAtivação LinfocitáriaMasculinoProteína Tirosina Fosfatase não Receptora Tipo 1Receptores de Antígenos de Linfócitos T/análiseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMascarenhas RE Peripheral....pdfMascarenhas RE Peripheral....pdfapplication/pdf104257https://www.arca.fiocruz.br/bitstream/icict/8125/1/Mascarenhas%20RE%20Peripheral....pdf4dc4c7251d1044a9224bd81ccfb7a0a2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8125/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMascarenhas RE Peripheral....pdf.txtMascarenhas RE Peripheral....pdf.txtExtracted texttext/plain29653https://www.arca.fiocruz.br/bitstream/icict/8125/3/Mascarenhas%20RE%20Peripheral....pdf.txtd9b034418145ec2a85f17a74eebbd943MD53icict/81252023-03-15 14:32:59.271oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens |
title |
Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens |
spellingShingle |
Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens Mascarenhas, Rita Elizabeth Moreira Antígenos/imunologia Infecções por HTLV-I/imunologia Vírus 1 Linfotrópico T Humano/imunologia Tolerância Imunológica/imunologia Leucócitos Mononucleares/imunologia Subpopulações de Linfócitos T/imunologia Adulto Antígenos CD45/biossíntese Linfócitos T CD4-Positivos/citologia Proliferação de Células Feminino Humanos Memória Imunológica Leucócitos Mononucleares/citologia Ativação Linfocitária Masculino Proteína Tirosina Fosfatase não Receptora Tipo 1 Receptores de Antígenos de Linfócitos T/análise |
title_short |
Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens |
title_full |
Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens |
title_fullStr |
Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens |
title_full_unstemmed |
Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens |
title_sort |
Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens |
author |
Mascarenhas, Rita Elizabeth Moreira |
author_facet |
Mascarenhas, Rita Elizabeth Moreira Brodskyn, Claudia Ida Barbosa, Geisa Clarêncio, Jorge Andrade Filho, Antonio de Souza Figueiroa, Frederico Castro Filho, Bernardo Galvão Grassi, Maria Fernanda Rios |
author_role |
author |
author2 |
Brodskyn, Claudia Ida Barbosa, Geisa Clarêncio, Jorge Andrade Filho, Antonio de Souza Figueiroa, Frederico Castro Filho, Bernardo Galvão Grassi, Maria Fernanda Rios |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Mascarenhas, Rita Elizabeth Moreira Brodskyn, Claudia Ida Barbosa, Geisa Clarêncio, Jorge Andrade Filho, Antonio de Souza Figueiroa, Frederico Castro Filho, Bernardo Galvão Grassi, Maria Fernanda Rios |
dc.subject.decs.pt_BR.fl_str_mv |
Antígenos/imunologia Infecções por HTLV-I/imunologia Vírus 1 Linfotrópico T Humano/imunologia Tolerância Imunológica/imunologia Leucócitos Mononucleares/imunologia Subpopulações de Linfócitos T/imunologia Adulto Antígenos CD45/biossíntese Linfócitos T CD4-Positivos/citologia Proliferação de Células Feminino Humanos Memória Imunológica Leucócitos Mononucleares/citologia Ativação Linfocitária Masculino Proteína Tirosina Fosfatase não Receptora Tipo 1 Receptores de Antígenos de Linfócitos T/análise |
topic |
Antígenos/imunologia Infecções por HTLV-I/imunologia Vírus 1 Linfotrópico T Humano/imunologia Tolerância Imunológica/imunologia Leucócitos Mononucleares/imunologia Subpopulações de Linfócitos T/imunologia Adulto Antígenos CD45/biossíntese Linfócitos T CD4-Positivos/citologia Proliferação de Células Feminino Humanos Memória Imunológica Leucócitos Mononucleares/citologia Ativação Linfocitária Masculino Proteína Tirosina Fosfatase não Receptora Tipo 1 Receptores de Antígenos de Linfócitos T/análise |
description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2014-08-04T18:42:15Z |
dc.date.available.fl_str_mv |
2014-08-04T18:42:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MASCARENHAS, R. E. et al. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clinical and Vaccine Immunology, v. 13, n. 5, p. 547-552, 2006. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/8125 |
dc.identifier.issn.none.fl_str_mv |
1556-6811 |
dc.identifier.doi.none.fl_str_mv |
10.1128/CVI.13.5.547–552.2006 |
identifier_str_mv |
MASCARENHAS, R. E. et al. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clinical and Vaccine Immunology, v. 13, n. 5, p. 547-552, 2006. 1556-6811 10.1128/CVI.13.5.547–552.2006 |
url |
https://www.arca.fiocruz.br/handle/icict/8125 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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American Society for Microbiology |
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American Society for Microbiology |
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