Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15182 |
Resumo: | Brazilian National Research Council – CNPq |
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Santana, Claudia de CarvalhoVassallo, JoseFreitas, Luiz Antonio Rodrigues deOliveira, Geraldo Gileno de SáPontes-de-Carvalho, Lain CarlosdosSantos, Washington Luis Conrado2016-08-02T17:47:43Z2016-08-02T17:47:43Z2008SANTANA, C. C. et al. Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs. Parasite Immunology, v. 30, p. 515–524, 2008.0141-9838https://www.arca.fiocruz.br/handle/icict/1518210.1111/j.1365-3024.2008.01051.xBrazilian National Research Council – CNPqFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade de Campinas, Cidade Universitária ‘Zeferino Vaz’. Faculdade de Ciências Médicas. Campinas, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe aim of this study was to identify splenic immuno-inflammatory patterns associated with natural infection by Leishmania chagasi. Spleen samples were obtained from 72 stray dogs from an endemic area of visceral leishmaniasis. The animals were grouped into four categories as follows: (i) potentially resistant to visceral leishmaniasis, with a positive leishmanin skin test result, and negative splenic culture for Leishmania parasites (ii) potentially susceptible to visceral leishmaniasis, with a negative leishmanin skin test and positive splenic culture for Leishmania (iii) infected with undefined susceptibility status, with a positive leishmanin skin test and positive splenic culture for Leishmania, and (iv) noninfected, with a negative leishmanin skin test, negative splenic culture for Leishmania, and negative serology for anti-Leishmania antibodies. Histopathological analyses showed that there was a higher frequency of perisplenitis (18/25, P < 0.0001), granuloma (7/25, P = 0.0102), structural disorganization (14/25, P < 0.0001), and atrophy of the lymphoid follicles (20/25, P = 0.0036) and of the marginal zone (15/25, P = 0.0025) in the potentially susceptible group than in the other groups. The data presented here show changes in the white pulp of the spleen that are associated with naturally acquired visceral leishmaniasis.engWileyInflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCanine visceral leishmaniasisLeishmania chagasiLeishmania infantumLymphoid tissueSpleenAnimalsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15182/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantana CC Inflammation and structural changes....pdfSantana CC Inflammation and structural changes....pdfapplication/pdf273777https://www.arca.fiocruz.br/bitstream/icict/15182/2/Santana%20CC%20Inflammation%20and%20structural%20changes....pdf37126a78938292e382fbb432a55dc4e0MD52TEXTSantana CC Inflammation and structural changes....pdf.txtSantana CC Inflammation and structural changes....pdf.txtExtracted texttext/plain44381https://www.arca.fiocruz.br/bitstream/icict/15182/3/Santana%20CC%20Inflammation%20and%20structural%20changes....pdf.txt48fd71fcbfed107c9c28f732c3bfb3f6MD53icict/151822023-03-15 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| dc.title.pt_BR.fl_str_mv |
Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs |
| title |
Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs |
| spellingShingle |
Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs Santana, Claudia de Carvalho Canine visceral leishmaniasis Leishmania chagasi Leishmania infantum Lymphoid tissue Spleen Animals |
| title_short |
Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs |
| title_full |
Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs |
| title_fullStr |
Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs |
| title_full_unstemmed |
Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs |
| title_sort |
Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs |
| author |
Santana, Claudia de Carvalho |
| author_facet |
Santana, Claudia de Carvalho Vassallo, Jose Freitas, Luiz Antonio Rodrigues de Oliveira, Geraldo Gileno de Sá Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado |
| author_role |
author |
| author2 |
Vassallo, Jose Freitas, Luiz Antonio Rodrigues de Oliveira, Geraldo Gileno de Sá Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Santana, Claudia de Carvalho Vassallo, Jose Freitas, Luiz Antonio Rodrigues de Oliveira, Geraldo Gileno de Sá Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado |
| dc.subject.en.pt_BR.fl_str_mv |
Canine visceral leishmaniasis Leishmania chagasi Leishmania infantum Lymphoid tissue Spleen Animals |
| topic |
Canine visceral leishmaniasis Leishmania chagasi Leishmania infantum Lymphoid tissue Spleen Animals |
| description |
Brazilian National Research Council – CNPq |
| publishDate |
2008 |
| dc.date.issued.fl_str_mv |
2008 |
| dc.date.accessioned.fl_str_mv |
2016-08-02T17:47:43Z |
| dc.date.available.fl_str_mv |
2016-08-02T17:47:43Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
SANTANA, C. C. et al. Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs. Parasite Immunology, v. 30, p. 515–524, 2008. |
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https://www.arca.fiocruz.br/handle/icict/15182 |
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0141-9838 |
| dc.identifier.doi.none.fl_str_mv |
10.1111/j.1365-3024.2008.01051.x |
| identifier_str_mv |
SANTANA, C. C. et al. Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: a study on naturally infected dogs. Parasite Immunology, v. 30, p. 515–524, 2008. 0141-9838 10.1111/j.1365-3024.2008.01051.x |
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Wiley |
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Wiley |
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