Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study

Detalhes bibliográficos
Autor(a) principal: Sá, Ricardo Tristão
Data de Publicação: 2012
Outros Autores: Kubelka, Claire Fernandes, Zandonade, Eliana, Zagne, Sônia Maria Oliveira, Rocha, Natally de Souza Maciel, Zagne, Luiza Oliveira, Araújo, Nathália Félix, Amin, Beatriz, Fazoli, Flávia, Souza, Luiz José de, Cruz, Oswaldo Gonçalves, Cunha, Rivaldo Venâncio da, Nascimento, Delso do, Froes, Iris Bucher, Nogueira, Rita Maria Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36736
Resumo: Santa Casa de Misericórdia de Vitória. Escola Superior de Ciências. Departamento de Clínica Médica. Vitória, ES, Brasil.
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spelling Sá, Ricardo TristãoKubelka, Claire FernandesZandonade, ElianaZagne, Sônia Maria OliveiraRocha, Natally de Souza MacielZagne, Luiza OliveiraAraújo, Nathália FélixAmin, BeatrizFazoli, FláviaSouza, Luiz José deCruz, Oswaldo GonçalvesCunha, Rivaldo Venâncio daNascimento, Delso doFroes, Iris BucherNogueira, Rita Maria Ribeiro2019-10-29T13:24:04Z2019-10-29T13:24:04Z2012SÁ, Ricardo Tristão et al. Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 6, p. 675-681, Nov./Dec. 2012.0037-8682https://www.arca.fiocruz.br/handle/icict/3673610.1590/s0037-868220120006000041678-9849engSociedade Brasileira de Medicina TropicalDengueDisfunção hepáticaPersistência dos sintomasCoorte em perspectivaDengueHepatic dysfunctionPersistence of symptomsProspective cohortClinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSanta Casa de Misericórdia de Vitória. Escola Superior de Ciências. Departamento de Clínica Médica. Vitória, ES, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Espírito Santo. Programa de Pós Graduação em Saúde Coletiva. Vitória, ES, Brasil.Universidade Federal Fluminense. Departamento de Clínica Médica. Niterói, RJ, Brasil.Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil.Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil.Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil.Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil.Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil.Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Introduction: To analyze the liver dysfunction and evolution of signs and symptoms in adult dengue patients during a two-month follow-up period. Methods: A prospective cohort study was conducted in Campos dos Goytacazes, Rio de Janeiro, Brazil, from January to July, 2008. The evolution of laboratory and clinical manifestations of 90 adult dengue patients was evaluated in five scheduled visits within a two-month follow-up period. Twenty controls were enrolled for the analysis of liver function. Patients with hepatitis B, hepatitis C, those known to be human immunodeficiency virus (HIV) seropositive and pregnant women were excluded from the study. Results: At the end of the second month following diagnosis, we observed that symptoms persisted in 33.3% (30/90) of dengue patients. We also observed that, 57.7% (15/26) of the symptoms persisted at the end of the second month. The most persistent symptoms were arthralgia, fatigue, weakness, adynamia, anorexia, taste alteration, and hair loss. Prior dengue virus (DENV) infection did not predispose patients to a longer duration of symptoms. Among hepatic functions, transaminases had the most remarkable elevation and in some cases remained elevated up to the second month after the disease onset. Alanine aminotransferase (ALT) levels overcame aspartate aminotransferase (AST) during the convalescent period. Male patients were more severely affected than females. Conclusions: Dengue fever may present a wide number of symptoms and elevated liver transaminases at the end of the second month.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36736/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClaireKubelka_RitaMNogueira_etal_IOC_2012.pdfClaireKubelka_RitaMNogueira_etal_IOC_2012.pdfapplication/pdf1164679https://www.arca.fiocruz.br/bitstream/icict/36736/2/ClaireKubelka_RitaMNogueira_etal_IOC_2012.pdf6c5ca0d6ca60e8158e5277bc7362ed92MD52TEXTClaireKubelka_RitaMNogueira_etal_IOC_2012.pdf.txtClaireKubelka_RitaMNogueira_etal_IOC_2012.pdf.txtExtracted texttext/plain41222https://www.arca.fiocruz.br/bitstream/icict/36736/3/ClaireKubelka_RitaMNogueira_etal_IOC_2012.pdf.txt4a6d7034c761e76af7dde9f6f4b5c965MD53icict/367362019-11-26 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dc.title.pt_BR.fl_str_mv Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study
title Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study
spellingShingle Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study
Sá, Ricardo Tristão
Dengue
Disfunção hepática
Persistência dos sintomas
Coorte em perspectiva
Dengue
Hepatic dysfunction
Persistence of symptoms
Prospective cohort
title_short Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study
title_full Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study
title_fullStr Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study
title_full_unstemmed Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study
title_sort Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study
author Sá, Ricardo Tristão
author_facet Sá, Ricardo Tristão
Kubelka, Claire Fernandes
Zandonade, Eliana
Zagne, Sônia Maria Oliveira
Rocha, Natally de Souza Maciel
Zagne, Luiza Oliveira
Araújo, Nathália Félix
Amin, Beatriz
Fazoli, Flávia
Souza, Luiz José de
Cruz, Oswaldo Gonçalves
Cunha, Rivaldo Venâncio da
Nascimento, Delso do
Froes, Iris Bucher
Nogueira, Rita Maria Ribeiro
author_role author
author2 Kubelka, Claire Fernandes
Zandonade, Eliana
Zagne, Sônia Maria Oliveira
Rocha, Natally de Souza Maciel
Zagne, Luiza Oliveira
Araújo, Nathália Félix
Amin, Beatriz
Fazoli, Flávia
Souza, Luiz José de
Cruz, Oswaldo Gonçalves
Cunha, Rivaldo Venâncio da
Nascimento, Delso do
Froes, Iris Bucher
Nogueira, Rita Maria Ribeiro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sá, Ricardo Tristão
Kubelka, Claire Fernandes
Zandonade, Eliana
Zagne, Sônia Maria Oliveira
Rocha, Natally de Souza Maciel
Zagne, Luiza Oliveira
Araújo, Nathália Félix
Amin, Beatriz
Fazoli, Flávia
Souza, Luiz José de
Cruz, Oswaldo Gonçalves
Cunha, Rivaldo Venâncio da
Nascimento, Delso do
Froes, Iris Bucher
Nogueira, Rita Maria Ribeiro
dc.subject.other.pt_BR.fl_str_mv Dengue
Disfunção hepática
Persistência dos sintomas
Coorte em perspectiva
topic Dengue
Disfunção hepática
Persistência dos sintomas
Coorte em perspectiva
Dengue
Hepatic dysfunction
Persistence of symptoms
Prospective cohort
dc.subject.en.pt_BR.fl_str_mv Dengue
Hepatic dysfunction
Persistence of symptoms
Prospective cohort
description Santa Casa de Misericórdia de Vitória. Escola Superior de Ciências. Departamento de Clínica Médica. Vitória, ES, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-29T13:24:04Z
dc.date.available.fl_str_mv 2019-10-29T13:24:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SÁ, Ricardo Tristão et al. Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 6, p. 675-681, Nov./Dec. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36736
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
dc.identifier.doi.none.fl_str_mv 10.1590/s0037-86822012000600004
dc.identifier.eissn.none.fl_str_mv 1678-9849
identifier_str_mv SÁ, Ricardo Tristão et al. Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 6, p. 675-681, Nov./Dec. 2012.
0037-8682
10.1590/s0037-86822012000600004
1678-9849
url https://www.arca.fiocruz.br/handle/icict/36736
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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