Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance

Detalhes bibliográficos
Autor(a) principal: Santos, Théo Araújo
Data de Publicação: 2017
Outros Autores: Andrade, Bruno de Bezerril, Santana, Leonardo Gil, Luz, Nívea Farias, Santos, Priscila Lima dos, Oliveira, Fabrícia A. de, Almeida, Meirielly Lima, Campos, Roseane Nunes de Santana, Bozza, Patrícia Torres, Almeida, Roque Pacheco de, Borges, Valeria de Matos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20030
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V.M.B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V.M.B., 552721/2011-5 and 019.203.02712/2009-8 FAPITEC/CNPq to R.P.A.). R.P.A. also received a grant from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES: 23038.005304/2011-01).
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spelling Santos, Théo AraújoAndrade, Bruno de BezerrilSantana, Leonardo GilLuz, Nívea FariasSantos, Priscila Lima dosOliveira, Fabrícia A. deAlmeida, Meirielly LimaCampos, Roseane Nunes de SantanaBozza, Patrícia TorresAlmeida, Roque Pacheco deBorges, Valeria de Matos2017-07-10T18:37:39Z2017-07-10T18:37:39Z2017SANTOS, T. A. et al. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance. Scientific Reports, v. 7, n.1, p. 4334, 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2003010.1038/s41598-017-04595-8Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V.M.B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V.M.B., 552721/2011-5 and 019.203.02712/2009-8 FAPITEC/CNPq to R.P.A.). R.P.A. also received a grant from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES: 23038.005304/2011-01).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Oeste da Bahia. Centro das Ciências Biológicas e da Saúde. Barreiras, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Salvador. UNIFACS. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilVisceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play a critical role in the development of this disease. Here, we perform a prospective exploratory study addressing whether simultaneous assessment of circulating levels of different lipid mediators and cytokines could highlight specific pathways involved with VL pathogenesis. VL patients displayed substantial increases in serum levels of Prostaglandin F2α (PGF2α), Leukotriene B4 (LTB4), Resolvin D1 (RvD1), IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α compared with uninfected endemic control group, while exhibiting decreased levels of TGF-β1. Hierarchical cluster analysis of the prospective changes in the expression level of theses parameters upon anti-Leishmania treatment initiation revealed that the inflammatory profile observed in active disease gradually changed over time and was generally reversed at day 30 of therapy. Furthermore, not only the individual concentrations of most of the inflammatory biomarkers changed upon treatment, but the correlations between those and several biochemical parameters used to characterize VL disease activity were also modified over time. These results demonstrate that an inflammatory imbalance hallmarks active VL disease and open perspective for manipulation of these pathways in future studies examining a potential host-directed therapy against VL.engNature Publishing GroupLeishmaniose visceralBiomarcadoresSaúde públicaTratamentoInflamaçãoVisceral leishmaniasisBiomarkersPublic healthTreatmentInflammationAnti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20030/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos TA Anti-parasite therapy....pdfSantos TA Anti-parasite 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dc.title.pt_BR.fl_str_mv Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
title Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
spellingShingle Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
Santos, Théo Araújo
Leishmaniose visceral
Biomarcadores
Saúde pública
Tratamento
Inflamação
Visceral leishmaniasis
Biomarkers
Public health
Treatment
Inflammation
title_short Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
title_full Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
title_fullStr Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
title_full_unstemmed Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
title_sort Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
author Santos, Théo Araújo
author_facet Santos, Théo Araújo
Andrade, Bruno de Bezerril
Santana, Leonardo Gil
Luz, Nívea Farias
Santos, Priscila Lima dos
Oliveira, Fabrícia A. de
Almeida, Meirielly Lima
Campos, Roseane Nunes de Santana
Bozza, Patrícia Torres
Almeida, Roque Pacheco de
Borges, Valeria de Matos
author_role author
author2 Andrade, Bruno de Bezerril
Santana, Leonardo Gil
Luz, Nívea Farias
Santos, Priscila Lima dos
Oliveira, Fabrícia A. de
Almeida, Meirielly Lima
Campos, Roseane Nunes de Santana
Bozza, Patrícia Torres
Almeida, Roque Pacheco de
Borges, Valeria de Matos
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Théo Araújo
Andrade, Bruno de Bezerril
Santana, Leonardo Gil
Luz, Nívea Farias
Santos, Priscila Lima dos
Oliveira, Fabrícia A. de
Almeida, Meirielly Lima
Campos, Roseane Nunes de Santana
Bozza, Patrícia Torres
Almeida, Roque Pacheco de
Borges, Valeria de Matos
dc.subject.other.pt_BR.fl_str_mv Leishmaniose visceral
Biomarcadores
Saúde pública
Tratamento
Inflamação
topic Leishmaniose visceral
Biomarcadores
Saúde pública
Tratamento
Inflamação
Visceral leishmaniasis
Biomarkers
Public health
Treatment
Inflammation
dc.subject.en.pt_BR.fl_str_mv Visceral leishmaniasis
Biomarkers
Public health
Treatment
Inflammation
description Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V.M.B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V.M.B., 552721/2011-5 and 019.203.02712/2009-8 FAPITEC/CNPq to R.P.A.). R.P.A. also received a grant from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES: 23038.005304/2011-01).
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-07-10T18:37:39Z
dc.date.available.fl_str_mv 2017-07-10T18:37:39Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, T. A. et al. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance. Scientific Reports, v. 7, n.1, p. 4334, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20030
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-017-04595-8
identifier_str_mv SANTOS, T. A. et al. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance. Scientific Reports, v. 7, n.1, p. 4334, 2017.
2045-2322
10.1038/s41598-017-04595-8
url https://www.arca.fiocruz.br/handle/icict/20030
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/20030/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/20030/2/Santos%20TA%20Anti-parasite%20therapy....pdf
https://www.arca.fiocruz.br/bitstream/icict/20030/3/Santos%20TA%20Anti-parasite%20therapy....pdf.txt
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