Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20030 |
Resumo: | Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V.M.B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V.M.B., 552721/2011-5 and 019.203.02712/2009-8 FAPITEC/CNPq to R.P.A.). R.P.A. also received a grant from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES: 23038.005304/2011-01). |
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Santos, Théo AraújoAndrade, Bruno de BezerrilSantana, Leonardo GilLuz, Nívea FariasSantos, Priscila Lima dosOliveira, Fabrícia A. deAlmeida, Meirielly LimaCampos, Roseane Nunes de SantanaBozza, Patrícia TorresAlmeida, Roque Pacheco deBorges, Valeria de Matos2017-07-10T18:37:39Z2017-07-10T18:37:39Z2017SANTOS, T. A. et al. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance. Scientific Reports, v. 7, n.1, p. 4334, 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2003010.1038/s41598-017-04595-8Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V.M.B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V.M.B., 552721/2011-5 and 019.203.02712/2009-8 FAPITEC/CNPq to R.P.A.). R.P.A. also received a grant from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES: 23038.005304/2011-01).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Oeste da Bahia. Centro das Ciências Biológicas e da Saúde. Barreiras, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Salvador. UNIFACS. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Departamento de Medicina e Patologia. Aracaju, SE, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilVisceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play a critical role in the development of this disease. Here, we perform a prospective exploratory study addressing whether simultaneous assessment of circulating levels of different lipid mediators and cytokines could highlight specific pathways involved with VL pathogenesis. VL patients displayed substantial increases in serum levels of Prostaglandin F2α (PGF2α), Leukotriene B4 (LTB4), Resolvin D1 (RvD1), IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α compared with uninfected endemic control group, while exhibiting decreased levels of TGF-β1. Hierarchical cluster analysis of the prospective changes in the expression level of theses parameters upon anti-Leishmania treatment initiation revealed that the inflammatory profile observed in active disease gradually changed over time and was generally reversed at day 30 of therapy. Furthermore, not only the individual concentrations of most of the inflammatory biomarkers changed upon treatment, but the correlations between those and several biochemical parameters used to characterize VL disease activity were also modified over time. These results demonstrate that an inflammatory imbalance hallmarks active VL disease and open perspective for manipulation of these pathways in future studies examining a potential host-directed therapy against VL.engNature Publishing GroupLeishmaniose visceralBiomarcadoresSaúde públicaTratamentoInflamaçãoVisceral leishmaniasisBiomarkersPublic healthTreatmentInflammationAnti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20030/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos TA Anti-parasite therapy....pdfSantos TA Anti-parasite therapy....pdfapplication/pdf2628888https://www.arca.fiocruz.br/bitstream/icict/20030/2/Santos%20TA%20Anti-parasite%20therapy....pdf321b8dfa0ee964ed39ae7d1d9e55e866MD52TEXTSantos TA Anti-parasite therapy....pdf.txtSantos TA Anti-parasite therapy....pdf.txtExtracted texttext/plain42460https://www.arca.fiocruz.br/bitstream/icict/20030/3/Santos%20TA%20Anti-parasite%20therapy....pdf.txt1aa2dab34feccb191fcbb0bebb5c970dMD53icict/200302023-03-15 14:33:54.535oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv |
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance |
title |
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance |
spellingShingle |
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance Santos, Théo Araújo Leishmaniose visceral Biomarcadores Saúde pública Tratamento Inflamação Visceral leishmaniasis Biomarkers Public health Treatment Inflammation |
title_short |
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance |
title_full |
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance |
title_fullStr |
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance |
title_full_unstemmed |
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance |
title_sort |
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance |
author |
Santos, Théo Araújo |
author_facet |
Santos, Théo Araújo Andrade, Bruno de Bezerril Santana, Leonardo Gil Luz, Nívea Farias Santos, Priscila Lima dos Oliveira, Fabrícia A. de Almeida, Meirielly Lima Campos, Roseane Nunes de Santana Bozza, Patrícia Torres Almeida, Roque Pacheco de Borges, Valeria de Matos |
author_role |
author |
author2 |
Andrade, Bruno de Bezerril Santana, Leonardo Gil Luz, Nívea Farias Santos, Priscila Lima dos Oliveira, Fabrícia A. de Almeida, Meirielly Lima Campos, Roseane Nunes de Santana Bozza, Patrícia Torres Almeida, Roque Pacheco de Borges, Valeria de Matos |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Théo Araújo Andrade, Bruno de Bezerril Santana, Leonardo Gil Luz, Nívea Farias Santos, Priscila Lima dos Oliveira, Fabrícia A. de Almeida, Meirielly Lima Campos, Roseane Nunes de Santana Bozza, Patrícia Torres Almeida, Roque Pacheco de Borges, Valeria de Matos |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose visceral Biomarcadores Saúde pública Tratamento Inflamação |
topic |
Leishmaniose visceral Biomarcadores Saúde pública Tratamento Inflamação Visceral leishmaniasis Biomarkers Public health Treatment Inflammation |
dc.subject.en.pt_BR.fl_str_mv |
Visceral leishmaniasis Biomarkers Public health Treatment Inflammation |
description |
Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V.M.B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V.M.B., 552721/2011-5 and 019.203.02712/2009-8 FAPITEC/CNPq to R.P.A.). R.P.A. also received a grant from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES: 23038.005304/2011-01). |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-07-10T18:37:39Z |
dc.date.available.fl_str_mv |
2017-07-10T18:37:39Z |
dc.date.issued.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, T. A. et al. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance. Scientific Reports, v. 7, n.1, p. 4334, 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20030 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-017-04595-8 |
identifier_str_mv |
SANTOS, T. A. et al. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance. Scientific Reports, v. 7, n.1, p. 4334, 2017. 2045-2322 10.1038/s41598-017-04595-8 |
url |
https://www.arca.fiocruz.br/handle/icict/20030 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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