Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8151 |
Resumo: | Universidade Federal da Bahia. Escola de Medicina da Bahia. Departamento de Patologia. Salvador, BA, Brasil. |
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Barbosa, Helenemarie SchaerBittencourt, Achilea Candida LisboaAraújo, Iguaracyra Barreto de OliveiraPereira Filho, Carlos SampaioFurlan, RobertoPedrosa, CéliaLessa, GildeteHarrington Junior, WilliamCastro Filho, Bernardo Galvão2014-08-07T17:53:41Z2014-08-07T17:53:41Z1999BARBOSA, Helenemarie Schaer et al. Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study. Journal of Acquired Immune Deficiency Syndromes, v. 21, n. 1, p. 65-71, 1999.1525-4135https://www.arca.fiocruz.br/handle/icict/8151engLippincott Williams & WilkinsAdult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Escola de Medicina da Bahia. Departamento de Patologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Medicina da Bahia. Departamento de Patologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Medicina da Bahia. Departamento de Patologia. Salvador, BA, Brasil.CICAN Oncology State Center. Salvador, BA, Brasil.San Raffaele Hospital. Experimental Neuroimmunology Unit DIBIT. Milan, Italy.University Hospital. Retrovirus Laboratory. Salvador, BA, Brasil.Oncology Nucleus. Salvador, BA, Brasil.University of Miami. Department of Hematology and Oncology. Miami, Florida, USA.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.The state of Bahia in the northeastern coast of Brazil is a region in which HTLV-I infection is endemic. This study investigated the characteristics of 28 HTLV-I-associated lymphomas/leukemias in this region. HTLV-I-infection diagnosis was based on serologic study, Southern blot analysis, and polymerase chain reaction (PCR) in neoplastic tissue. The main clinical differences between these lymphomas and adult T-cell leukemia (ATL) cases from other endemic areas were as follows. The mean age was 47 years; 20% of the cases occurred in young adults; and a predominance was found among male subjects (2:1), blacks, and of those of mixed race (96%). Histologically, 20 cases were T-cell pleomorphic leukemia/lymphoma, 5 were Mycosis fungoides-like cutaneous lymphoma, and 3 were CD30+ large-cell anaplastic lymphoma. Immunohistochemistry demonstrated 4 cases of CD8+ lymphoma. Proviral genomic sequences were demonstrated by PCR in 9 lymph node biopsy specimens and in 3 skin biopsy specimens. Southern blot was performed and was positive in 8 cases.HTLV-1-positive lymphomaAdult T-cell leukemia/lymohomaPleomorphic lymphomaVírus 1 Linfotrópico T Humano/isolamento & purificaçãoLeucemia-Linfoma de Células T do Adulto/epidemiologiaAdolescenteAdultoDistribuição por IdadeIdosoIdoso de 80 Anos ou maisSouthern BlottingBrasil/epidemiologiaDNA Viral/análiseEnsaio de Imunoadsorção EnzimáticaFemininoAnticorpos Anti-HTLV-I/sangueVírus 1 Linfotrópico T Humano/genéticaHumanosImuno-HistoquímicaImunofenotipagemLeucemia-Linfoma de Células T do Adulto/patologiaLinfonodos/patologiaMasculinoReação em Cadeia da PolimeraseMeia-IdadeEstudos SoroepidemiológicosDistribuição por SexoPele/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarbosa HS Adult T Cel....pdfBarbosa HS Adult T Cel....pdfapplication/pdf5229393https://www.arca.fiocruz.br/bitstream/icict/8151/1/Barbosa%20HS%20Adult%20T%20Cel....pdf1caed9147478107c4e5fa945dcc58b1eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8151/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBarbosa HS Adult T Cel....pdf.txtBarbosa HS Adult T Cel....pdf.txtExtracted texttext/plain7https://www.arca.fiocruz.br/bitstream/icict/8151/3/Barbosa%20HS%20Adult%20T%20Cel....pdf.txt212b0306580d4f0044d18f9a3edcc832MD53icict/81512023-03-15 14:33:05.039oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study |
| title |
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study |
| spellingShingle |
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study Barbosa, Helenemarie Schaer HTLV-1-positive lymphoma Adult T-cell leukemia/lymohoma Pleomorphic lymphoma Vírus 1 Linfotrópico T Humano/isolamento & purificação Leucemia-Linfoma de Células T do Adulto/epidemiologia Adolescente Adulto Distribuição por Idade Idoso Idoso de 80 Anos ou mais Southern Blotting Brasil/epidemiologia DNA Viral/análise Ensaio de Imunoadsorção Enzimática Feminino Anticorpos Anti-HTLV-I/sangue Vírus 1 Linfotrópico T Humano/genética Humanos Imuno-Histoquímica Imunofenotipagem Leucemia-Linfoma de Células T do Adulto/patologia Linfonodos/patologia Masculino Reação em Cadeia da Polimerase Meia-Idade Estudos Soroepidemiológicos Distribuição por Sexo Pele/patologia |
| title_short |
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study |
| title_full |
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study |
| title_fullStr |
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study |
| title_full_unstemmed |
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study |
| title_sort |
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study |
| author |
Barbosa, Helenemarie Schaer |
| author_facet |
Barbosa, Helenemarie Schaer Bittencourt, Achilea Candida Lisboa Araújo, Iguaracyra Barreto de Oliveira Pereira Filho, Carlos Sampaio Furlan, Roberto Pedrosa, Célia Lessa, Gildete Harrington Junior, William Castro Filho, Bernardo Galvão |
| author_role |
author |
| author2 |
Bittencourt, Achilea Candida Lisboa Araújo, Iguaracyra Barreto de Oliveira Pereira Filho, Carlos Sampaio Furlan, Roberto Pedrosa, Célia Lessa, Gildete Harrington Junior, William Castro Filho, Bernardo Galvão |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barbosa, Helenemarie Schaer Bittencourt, Achilea Candida Lisboa Araújo, Iguaracyra Barreto de Oliveira Pereira Filho, Carlos Sampaio Furlan, Roberto Pedrosa, Célia Lessa, Gildete Harrington Junior, William Castro Filho, Bernardo Galvão |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-1-positive lymphoma Adult T-cell leukemia/lymohoma Pleomorphic lymphoma |
| topic |
HTLV-1-positive lymphoma Adult T-cell leukemia/lymohoma Pleomorphic lymphoma Vírus 1 Linfotrópico T Humano/isolamento & purificação Leucemia-Linfoma de Células T do Adulto/epidemiologia Adolescente Adulto Distribuição por Idade Idoso Idoso de 80 Anos ou mais Southern Blotting Brasil/epidemiologia DNA Viral/análise Ensaio de Imunoadsorção Enzimática Feminino Anticorpos Anti-HTLV-I/sangue Vírus 1 Linfotrópico T Humano/genética Humanos Imuno-Histoquímica Imunofenotipagem Leucemia-Linfoma de Células T do Adulto/patologia Linfonodos/patologia Masculino Reação em Cadeia da Polimerase Meia-Idade Estudos Soroepidemiológicos Distribuição por Sexo Pele/patologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Vírus 1 Linfotrópico T Humano/isolamento & purificação Leucemia-Linfoma de Células T do Adulto/epidemiologia Adolescente Adulto Distribuição por Idade Idoso Idoso de 80 Anos ou mais Southern Blotting Brasil/epidemiologia DNA Viral/análise Ensaio de Imunoadsorção Enzimática Feminino Anticorpos Anti-HTLV-I/sangue Vírus 1 Linfotrópico T Humano/genética Humanos Imuno-Histoquímica Imunofenotipagem Leucemia-Linfoma de Células T do Adulto/patologia Linfonodos/patologia Masculino Reação em Cadeia da Polimerase Meia-Idade Estudos Soroepidemiológicos Distribuição por Sexo Pele/patologia |
| description |
Universidade Federal da Bahia. Escola de Medicina da Bahia. Departamento de Patologia. Salvador, BA, Brasil. |
| publishDate |
1999 |
| dc.date.issued.fl_str_mv |
1999 |
| dc.date.accessioned.fl_str_mv |
2014-08-07T17:53:41Z |
| dc.date.available.fl_str_mv |
2014-08-07T17:53:41Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
BARBOSA, Helenemarie Schaer et al. Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study. Journal of Acquired Immune Deficiency Syndromes, v. 21, n. 1, p. 65-71, 1999. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/8151 |
| dc.identifier.issn.none.fl_str_mv |
1525-4135 |
| identifier_str_mv |
BARBOSA, Helenemarie Schaer et al. Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study. Journal of Acquired Immune Deficiency Syndromes, v. 21, n. 1, p. 65-71, 1999. 1525-4135 |
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https://www.arca.fiocruz.br/handle/icict/8151 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Lippincott Williams & Wilkins |
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Lippincott Williams & Wilkins |
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