Circumventing the side effects of L-asparaginase

Detalhes bibliográficos
Autor(a) principal: Fonseca, Marcela Helena Gambim
Data de Publicação: 2021
Outros Autores: Fiúza, Tayná da Silva, Morais, Stephanie Bath de, Souza, Tatiana de Arruda Campos Brasil de, Trevizani, Raphael
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47629
https://doi.org/10.1016/j.biopha.2021.111616
Resumo: Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.
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spelling Fonseca, Marcela Helena GambimFiúza, Tayná da SilvaMorais, Stephanie Bath deSouza, Tatiana de Arruda Campos Brasil deTrevizani, Raphael2021-06-10T19:18:01Z2021-06-10T19:18:01Z2021FONSECA, Marcela Helena Gambim et al. Circumventing the side effects of L-asparaginase. Biomedicine & Pharmacotherapy, n. 139, p. 1–7, 2021.0753-3322https://www.arca.fiocruz.br/handle/icict/47629https://doi.org/10.1016/j.biopha.2021.111616porElsevierCircumventing the side effects of L-asparaginaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.Núcleo Multidisciplinar de Bioinformática. BioME, RN, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.L-asparaginase is an enzyme that catalyzes the degradation of asparagine and successfully used in the treatment of acute lymphoblastic leukemia. L-asparaginase toxicity is either related to hypersensitivity to the foreign protein or to a secondary L-glutaminase activity that causes inhibition of protein synthesis. PEGylated versions have been incorporated into the treatment protocols to reduce immunogenicity and an alternative L-asparaginase derived from Dickeya chrysanthemi is used in patients with anaphylactic reactions to the E. coli L-asparaginase. Alternative approaches commonly explore new sources of the enzyme as well as the use of protein engineering techniques to create less immunogenic, more stable variants with lower L-glutaminase activity. This article reviews the main strategies used to overcome L-asparaginase shortcomings and introduces recent tools that can be used to create therapeutic enzymes with improved features.ImmunogenicityImmunologic FactorsL-glutaminase activityHalf-LifeEpitope predictionDeimmunizationProtein EngineeringFactores InmunológicosGlutaminasaSemividaMapeo EpitopoIngeniería de ProteínasFacteurs immunologiquesPériodeCartographie épitopiqueIngénierie des protéinesFatores ImunológicosGlutaminaseMeia-VidaMapeamento de EpitoposEngenharia de Proteínasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Circumventing the side effects of L-asparaginase
title Circumventing the side effects of L-asparaginase
spellingShingle Circumventing the side effects of L-asparaginase
Fonseca, Marcela Helena Gambim
Immunogenicity
Immunologic Factors
L-glutaminase activity
Half-Life
Epitope prediction
Deimmunization
Protein Engineering
Factores Inmunológicos
Glutaminasa
Semivida
Mapeo Epitopo
Ingeniería de Proteínas
Facteurs immunologiques
Période
Cartographie épitopique
Ingénierie des protéines
Fatores Imunológicos
Glutaminase
Meia-Vida
Mapeamento de Epitopos
Engenharia de Proteínas
title_short Circumventing the side effects of L-asparaginase
title_full Circumventing the side effects of L-asparaginase
title_fullStr Circumventing the side effects of L-asparaginase
title_full_unstemmed Circumventing the side effects of L-asparaginase
title_sort Circumventing the side effects of L-asparaginase
author Fonseca, Marcela Helena Gambim
author_facet Fonseca, Marcela Helena Gambim
Fiúza, Tayná da Silva
Morais, Stephanie Bath de
Souza, Tatiana de Arruda Campos Brasil de
Trevizani, Raphael
author_role author
author2 Fiúza, Tayná da Silva
Morais, Stephanie Bath de
Souza, Tatiana de Arruda Campos Brasil de
Trevizani, Raphael
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Marcela Helena Gambim
Fiúza, Tayná da Silva
Morais, Stephanie Bath de
Souza, Tatiana de Arruda Campos Brasil de
Trevizani, Raphael
dc.subject.en.pt_BR.fl_str_mv Immunogenicity
Immunologic Factors
L-glutaminase activity
Half-Life
Epitope prediction
Deimmunization
Protein Engineering
topic Immunogenicity
Immunologic Factors
L-glutaminase activity
Half-Life
Epitope prediction
Deimmunization
Protein Engineering
Factores Inmunológicos
Glutaminasa
Semivida
Mapeo Epitopo
Ingeniería de Proteínas
Facteurs immunologiques
Période
Cartographie épitopique
Ingénierie des protéines
Fatores Imunológicos
Glutaminase
Meia-Vida
Mapeamento de Epitopos
Engenharia de Proteínas
dc.subject.es.pt_BR.fl_str_mv Factores Inmunológicos
Glutaminasa
Semivida
Mapeo Epitopo
Ingeniería de Proteínas
dc.subject.fr.pt_BR.fl_str_mv Facteurs immunologiques
Période
Cartographie épitopique
Ingénierie des protéines
dc.subject.decs.pt_BR.fl_str_mv Fatores Imunológicos
Glutaminase
Meia-Vida
Mapeamento de Epitopos
Engenharia de Proteínas
description Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-10T19:18:01Z
dc.date.available.fl_str_mv 2021-06-10T19:18:01Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Marcela Helena Gambim et al. Circumventing the side effects of L-asparaginase. Biomedicine & Pharmacotherapy, n. 139, p. 1–7, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47629
dc.identifier.issn.pt_BR.fl_str_mv 0753-3322
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.biopha.2021.111616
identifier_str_mv FONSECA, Marcela Helena Gambim et al. Circumventing the side effects of L-asparaginase. Biomedicine & Pharmacotherapy, n. 139, p. 1–7, 2021.
0753-3322
url https://www.arca.fiocruz.br/handle/icict/47629
https://doi.org/10.1016/j.biopha.2021.111616
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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